Projects for Graduate Studies
1. Combined genetic and immunophenotypic study of cutaneous lymphomas - the Oble lab in the department of Pathology in the Faculty of Medicine at the University of Manitoba is seeking one graduate student (MSc or PhD) to work on a project that seeks to better understand the pathophysiology of human cutaneous T-cell lymphomas. Currently the diagnosis of these lymphomas can be very difficult to make since there is a variety of clinicopathological presentations and the clinical and histopathological findings can be very subtle. The overall goal of this project is to identify the role of genetic events in the pathophysiology of these diseases and to determine whether different genetic changes segregate with specific subtypes, phenotypes, and/or stages of disease. We hypothesize that the genetic changes may be less random than currently thought and that certain genetic changes may occur recurrently within certain variants while others may mark the progression of disease.

2. Mouse Model of Human Psoriasiform Disease - the Oble lab in the Department of Pathology in the Faculty of Medicine at the University of Manitoba is seeking one graduate student (MSc or PhD) to study the pathophysiology of human psoriasiform disease using a mouse model of human skin disease.  Previously, we created a T-cell receptor (TCR) transgenic murine model of human psoriasiform disease which is ideal for the study of self-tolerance, regulatory T-cell (Treg) immunobiology, and autoimmune skin disease. Studying this unique model system, which has the potential to broaden our understanding of autoimmunity and lymphocyte immmunobiology, involves dissecting the complex interplay of various immune cell subsets, cutaneous epithelial cells (keratinocytes), and microorganisms.

Interested candidates are encouraged to email a letter of application,  the names of three referees, and a curriculum vitae to Dr. Darryl Oble at the address below.  Suitable candidate will be asked to apply to the Faculty of Graduate Studies. Selection will be based on academic achievements, reference letters and previous research experience.

Dr. Darryl Oble
Dept. of Pathology, University of Manitoba
Rm. 401-H, Brodie Centre, 727 McDermot Avenue
Winnipeg, MB, Canada,  R3E 3P5
Email: oble@cc.umanitoba.ca