Dr. Ray L. Somorjai

Group Leader Informatics, NRC Institutefor Biodiagnostics
435 Ellice Avenue, Winnipeg MB R3B 1Y6 Canada

Tel (204) 984-4538, Fax: (204) 983-3154
E-mail: somorjai@fermat.ibd.nrc.ca (Ray Somorjai)

Last update: November 7, 2002

Publications

Click the URL (Uniform resource Locator) to view the abstract in the bottom frame.

Soper, R., U. Himmelreich, D. Painter, R.L. Somorjai, C.L. Lean, B. Dolenko, C.E. Mountford & P. Russell (2002). Pathology of hepatocellular carcinoma and its precursors using proton magnetic resonance spectroscopy and a statistical classification strategy. Pathology 34(5), 417-422. URL = 12408339

El-Sayed, S., T. Bezabeh, O. Odlum, R. Patel, S. Ahing, K. MacDonald, R.L. Somorjai & I.C. Smith (2002). An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region. Head Neck 24(8), 766-772. URL = 12203802

Somorjai, R.L., R. Vivanco & N. Pizzi (2002). A novel, direct spatio-temporal approach for analyzing fMRI experiments. Artif Intell Med 25(1), 5-17. URL = 12009260

Somorjai, R.L. (2002). Exploratory data analysis in functional neuroimaging. Artif Intell Med 25(1), 1-3. URL = 12009259 (no abstract available)

Jarmasz, M. & R.L. Somorjai (2002). Exploring regions of interest with cluster analysis (EROICA) using a spectral peak statistic for selecting and testing the significance of fMRI activation time-series. Artif Intell Med 25(1), 45-67. URL = 12009263

Menard, C., I.C. Smith, R.L. Somorjai, L. Leboldus, R. Patel, C. Littman, S.J. Robertson & T. Bezabeh (2001). Magnetic resonance spectroscopy of the malignant prostate gland after radiotherapy: a histopathologic study of diagnostic validity. Int J Radiat Oncol Biol Phys 50(2), 317-323. URL = 11380217

Mountford, C.E., R.L. Somorjai, P. Malycha, L. Gluch, C. Lean, P. Russell, B. Barraclough, D. Gillett, U. Himmelreich, B. Dolenko, A.E. Nikulin & I.C. Smith (2001). Diagnosis and prognosis of breast cancer by magnetic resonance spectroscopy of fine-needle aspirates analysed using a statistical classification strategy. Br J Surg 88(9), 1234-1240. URL = 11531873.

Baumgartner, R., R. Somorjai, R. Summers & W. Richter (2001). Ranking fMRI Time Courses by Minimum Spanning Trees: Assessing Coactivation in fMRI. Neuroimage 13(4), 734-742. URL = PMID: 11305900

Bezabeh, T., R.L. Somorjai, I.C. Smith, A.E. Nikulin, B. Dolenko & C.N. Bernstein (2001). The use of 1H magnetic resonance spectroscopy in inflammatory bowel diseases: distinguishing ulcerative colitis from Crohn's disease. Am J Gastroenterol 96(2), 442-8. URL = 21122349

Pizzi, N.J., R.A. Vivanco & R.L. Somorjai (2001). EvIdent: a functional magnetic resonance image analysis system. Artif Intell Med 21(1-3), 263-269.

Alexander, M.E., R. Baumgartner, C. Windischberger, E. Moser & R.L. Somorjai (2000). Wavelet domain de-noising of time-courses in MR image sequences. Magn Reson Imaging 18(9), 1129-1134. URL = PMID: 11222905

Tuor, U.I., K. Malisza, T. Foniok, R. Papadimitropoulos, M. Jarmasz, R. Somorjai & P. Kozlowski (2000). Functional magnetic resonance imaging in rats subjected to intense electrical and noxious chemical stimulation of the forepaw. Pain 87(3), 315-24. URL = 20420255

Baumgartner, R., R. Somorjai, R. Summers, W. Richter & L. Ryner (2000). Novelty indices: identifiers of potentially interesting time-courses in functional MRI data. Magn Reson Imaging 18(7), 845-50. URL = 20483972

Baumgartner, R., R. Somorjai, R. Summers, W. Richter & L. Ryner (2000). Correlator beware: correlation has limited selectivity for fMRI data analysis. Neuroimage 12(2), 240-3. URL = 20375201

Richter, W., R. Somorjai, R. Summers, M. Jarmasz, R.S. Menon, J.S. Gati, A.P. Georgopoulos, C. Tegeler, K. Ugurbil & S.G. Kim (2000). Motor area activity during mental rotation studied by time-resolved single-trial fMRI. J Cogn Neurosci 12(2), 310-20. URL = 20235639 or URL = http://mitpress.mit.edu/journal-issue-abstracts.tcl?issn=0898929X&volume=12&issue=2

Baumgartner, R., R. Somorjai, R. Summers, W. Richter, L. Ryner & M. Jarmasz (2000). Resampling as a cluster validation technique in fMRI. J Magn Reson Imaging 11(2), 228-31. URL = 20178298

Alexander, M.E., R. Baumgartner, A.R. Summers, C. Windischberger, M. Klarhoefer, E. Moser & R.L. Somorjai (2000). A wavelet-based method for improving signal-to-noise ratio and contrast in MR images. Magn Reson Imaging 18(2), 169-80. URL = 20189976

Baumgartner, R., L. Ryner, W. Richter, R. Summers, M. Jarmasz & R. Somorjai (2000). Comparison of two exploratory data analysis methods for fMRI: fuzzy clustering vs. principal component analysis. Magn Reson Imaging 18(1), 89-94. URL = 20105092

Rush, D., R. Somorjai, R. Deslauriers, A. Shaw, J. Jeffery & P. Nickerson (2000). Subclinical rejection--a potential surrogate marker for chronic rejection--may be diagnosed by protocol biopsy or urine spectroscopy. Ann Transplant 5(2), 44-9. URL = 21086234

Davison, N.E., H. Eviatar & R.L. Somorjai (2000). Snakes simplified. Pattern Recognition , in press. Baumgartner, R., R. Somorjai, R. Summers & W. Richter (1999). Assessment of cluster homogeneity in fMRI data using Kendall's coefficient of concordance. Magn Reson Imaging 17(10), 1525-32. URL = 20076124

Tian, G., J.F. Shen, G. Dai, J. Sun, B. Xiang, Z. Luo, R. Somorjai & R. Deslauriers (1999). An interleaved T1-T2* imaging sequence for assessing myocardial injury. J Cardiovasc Magn Reson 1(2), 145-151. URL = 11550347.

Ye, J., G. Dai, L.N. Ryner, P. Kozlowski, L. Yang, R. Summers, J. Sun, T.A. Salerno, R.L. Somorjai & R. Deslauriers (1999). Unilateral antegrade cerebral perfusion through the right axillary artery provides uniform flow distribution to both hemispheres of the brain: A magnetic resonance and histopathological study in pigs. Circulation 100(19 Suppl), II309-15. URL = 20037059

Jackson, M., J.R. Mansfield, B. Dolenko, R.L. Somorjai, H.H. Mantsch & P.H. Watson (1999). Classification of breast tumors by grade and steroid receptor status using pattern recognition analysis of infrared spectra. Cancer Detect Prev 23(3), 245-53. URL = 99270829

Ye, J., L.N. Ryner, P. Kozlowski, L. Yang, M.R. Del Bigio, J. Sun, M. Donnelly, R. Summers, T.A. Salerno, R.L. Somorjai, J.K. Saunders & R. Deslauriers (1998). Retrograde cerebral perfusion results in flow distribution abnormalities and neuronal damage. A magnetic resonance imaging and histopathological study in pigs. Circulation 98(19 Suppl), II313-8. URL = 99070022

Bergeron, M., S. Faucher, T. Minkus, F. Lacroix, T. Ding, S. Phaneuf, R. Somorjai, R. Summers & F. Mandy (1998). Impact of unified procedures as implemented in the Canadian Quality Assurance Program for T lymphocyte subset enumeration. Participating Flow Cytometry Laboratories of the Canadian Clinical Trials Network for HIV/AIDS Therapies. Cytometry 33(2), 146-55. URL = 98444859

Nikulin, A.E., B. Dolenko, T. Bezabeh & R.L. Somorjai (1998). Near-optimal region selection for feature space reduction: novel preprocessing methods for classifying MR spectra. NMR Biomed 11(4-5), 209-16. URL = 98384080

Tian, G., J. Shen, J. Sun, B. Xiang, G.I. Oriaku, L. Zhezong, G. Scarth, R. Somorjai, J.K. Saunders, T.A. Salerno & R. Deslauriers (1998). Does simultaneous antegrade/retrograde cardioplegia improve myocardial perfusion in the areas at risk? A magnetic resonance perfusion imaging study in isolated pig hearts. J Thorac Cardiovasc Surg 115(4), 913-24. URL = 98235762

Baumgartner, R., G. Scarth, C. Teichtmeister, R. Somorjai & E. Moser (1997). Fuzzy clustering of gradient-echo functional MRI in the human visual cortex. Part I: reproducibility. J Magn Reson Imaging 7(6), 1094-101. URL = 98062026

Ye, J., L. Yang, M.R. Del Bigio, R. Summers, D. Jackson, R.L. Somorjai, T.A. Salerno & R. Deslauriers (1997). Retrograde cerebral perfusion provides limited distribution of blood to the brain: a study in pigs. J Thorac Cardiovasc Surg 114(4), 660-5. URL = 97478358

Wallace, J.C., G.P. Raaphorst, R.L. Somorjai, C.E. Ng, M. Fung Kee Fung, M. Senterman & I.C. Smith (1997). Classification of 1H MR spectra of biopsies from untreated and recurrent ovarian cancer using linear discriminant analysis. Magn Reson Med 38(4), 569-76. URL = 97464503

Mansfield, J.R., M.G. Sowa, G.B. Scarth, R.L. Somorjai & H.H. Mantsch (1997). Fuzzy C-means clustering and principal component analysis of time series from near-infrared imaging of forearm ischemia. Comput Med Imaging Graph 21(5), 299-308. URL = 98133583

Hahn, P., I.C. Smith, L. Leboldus, C. Littman, R.L. Somorjai & T. Bezabeh (1997). The classification of benign and malignant human prostate tissue by multivariate analysis of 1H magnetic resonance spectra. Cancer Res 57(16), 3398-401. URL = 97413618

Alexander, M.E., G. Scarth & R.L. Somorjai (1997). An improved robust hierarchical registration algorithm. Magn Reson Imaging 15(4), 505-14. URL = 97366242

Somorjai, R.L., B. Dolenko, A.K. Nikulin, N. Pizzi, G. Scarth, P. Zhilkin, W. Halliday, D. Fewer, N. Hill, I. Ross, M. West, I.C. Smith, S.M. Donnelly, A.C. Kuesel & K.M. Briere (1996). Classification of 1H MR spectra of human brain neoplasms: the influence of preprocessing and computerized consensus diagnosis on classification accuracy. J Magn Reson Imaging 6(3), 437-44. URL = 96344168

Bezabeh, T., I.C. Smith, E. Krupnik, R.L. Somorjai, D.G. Kitchen, C.N. Bernstein, N.M. Pettigrew, R.P. Bird, K.J. Lewin & K.M. Briere (1996). Diagnostic potential for cancer via 1H magnetic resonance spectroscopy of colon tissue. Anticancer Res 16(3B), 1553-8. URL = 96273120

Alexander, M.E. & R.L. Somorjai (1996). The registration of MR images using multiscale robust methods. Magn Reson Imaging 14(5), 453-68. URL = 97000273

Somorjai, R.L., A.E. Nikulin, N. Pizzi, D. Jackson, G. Scarth, B. Dolenko, H. Gordon, P. Russell, C.L. Lean, L. Delbridge and others (1995). Computerized consensus diagnosis: a classification strategy for the robust analysis of MR spectra. I. Application to 1H spectra of thyroid neoplasms. Magn Reson Med 33(2), 257-63. URL = 95223163

Pizzi, N., L.P. Choo, J. Mansfield, M. Jackson, W.C. Halliday, H.H. Mantsch & R.L. Somorjai (1995). Neural network classification of infrared spectra of control and Alzheimer's diseased tissue. Artif Intell Med 7(1), 67-79. URL = 95316069

Nauchitel, V.V. & R.L. Somorjai (1994). Spatial and free energy distribution patterns of amino acid residues in water soluble proteins. Biophys Chem 51(2-3), 327-36. URL = 95002594

Nauchitel, V.V. & R.L. Somorjai (1994). Antigen-antibody recognition. Model calculations. Biophys Chem 51(2-3), 337-47. URL = 95002595

Peters, T., B. Meyer, R. Stuike-Prill, R. Somorjai & J.R. Brisson (1993). A Monte Carlo method for conformational analysis of saccharides. Carbohydr Res 238, 49-73. URL = 93161358

Nauchitel, V.V. & R.L. Somorjai (1993). Gaussian neighborhood: a new measure of accessibility for residues of protein molecules. Proteins 15(1), 50-61. URL = 93197290

Gordon, H.L. & R.L. Somorjai (1992). Fuzzy cluster analysis of molecular dynamics trajectories. Proteins 14(2), 249-64. URL = 93028359

Neugebauer, W., W.K. Surewicz, H.L. Gordon, R.L. Somorjai, W. Sung & G.E. Willick (1992). Structural elements of human parathyroid hormone and their possible relation to biological activities. Biochemistry 31(7), 2056-63. URL = 92162708

Sylvain, M. & R.L. Somorjai (1991). Novel approach for computing the global minimum of proteins. 2. One-dimensional test cases. J. Phys. Chem. 95, 4147-4152.

Somorjai, R.L. (1991). Novel approach for computing the global minimum of proteins. 1. General concepts, methods, and approximations. J. Phys. Chem. 95, 4141-4146.

Phipps, M., J. Phipps, J.F. Whitfield, A. Ally, R.L. Somorjai & S.A. Narang (1990). Carcinogenic implications of the neighborhood coherence principle (NCP). Med Hypotheses 31(4), 289-301. URL = 90286966

Somorjai, R.L. (1990). Theories and simulation of protein folding. Biotechnology 14, 1-19. URL = 90227296 (no abstract available)

Remin, M., R.L. Somorjai, R. Deslauriers, E.J. Princz & I.C. Smith (1989). 1H magnetic resonance of human tumours. Analysis of the transverse relaxation of the methylene protons using continuous distributions of relaxation times. NMR Biomed 2(4), 142-50. URL = 90359698

Zuker, M. & R.L. Somorjai (1989). The alignment of protein structures in three dimensions. Bull Math Biol 51(1), 55-78. URL = 89207961

Klein, P., R.L. Somorjai & P.C. Lau (1988). Distinctive properties of signal sequences from bacterial lipoproteins. Protein Eng 2(1), 15-20. URL = 89315701

Klein, P. & R.L. Somorjai (1988). Nonlinear methods for discrimination and their application to classification of protein structures. J Theor Biol 130(4), 461-8. URL = 89038575

Deslauriers, R., R.L. Somorjai, Y. Geoffrion, T. Kroft, I.C. Smith & J.K. Saunders (1988). 1H and 13C NMR studies of tissue from normal and diseased mice. Analysis of T1 and T2 relaxation profiles of triglycerides in liver. NMR Biomed 1(1), 32-43. URL = 90351896

Narang, S.A., J. Phipps, F.L. Yao, J.J. Michniewicz, G. Dubuc & R.L. Somorjai (1987). Observation of a possible pause mutant in the total synthesis of T4 lysozyme. Biochem Biophys Res Commun 149(2), 340-6. URL = 88106442

Narang, S.A., F.L. Yao, J.J. Michniewicz, G. Dubuc, J. Phipps & R.L. Somorjai (1987). Hierarchical strategy for protein folding and design: synthesis and expression of T4 lysozyme gene and two putative folding mutants. Protein Eng 1(6), 481-5. URL = 89220987

Butler, K.W., R. Deslauriers, Y. Geoffrion, J.M. Storey, K.B. Storey, I.C. Smith & R.L. Somorjai (1985). 31P nuclear magnetic resonance studies of crayfish (Orconectes virilis). The use of inversion spin transfer to monitor enzyme kinetics in vivo. Eur J Biochem 149(1), 79-83. URL = 85203897

Siebrand, W., R.L. Somorjai & T.A. Wildman (1985). Structural interpretation of low-temperature heme-ligand recombination rates in myoglobin. FEBS Lett 183(2), 191-4. URL = 85179976

Louie, A.H. & R.L. Somorjai (1984). Stieltjes integration and differential geometry: a model for enzyme recognition, discrimination, and catalysis. Bull Math Biol 46(5-6), 745-64. URL = 85098328 (no abstract available)

Louie, A.H. & R.L. Somorjai (1983). Differential geometry of proteins. Helical approximations. J Mol Biol 168(1), 143-62. URL = 83268703

Louie, A.H. & R.L. Somorjai (1982). Differential geometry of proteins: a structural and dynamical representation of patterns. J Theor Biol 98(2), 189-209. URL = 83087241 (no abstract available)

Deslauriers, R., I.C. Smith, R.L. Somorjai, E. Ralston, R.C. Orlowski & R. Walter (1979). Effects of D and L amino acid residues in linear peptides on carbon-13 nuclear magnetic resonance parameters. Int J Pept Protein Res 13(5), 473-8. URL = 79238732

Rosen, R., H.H. Pattee & R.L. Somorjai (1979). A symposium in theoretical biology. In: Buckley, P.J. & F.D. Peat, A Question of Physics: Conversations in Physics and Biology, Toronto: University of Toronto Press, p. 84-123.

Tancrede, P., R. Deslauriers, W.H. McGregor, E. Ralston, D. Sarantakis, R.L. Somorjai & I.C. Smith (1978). A carbon-13 nuclear magnetic resonance study of the molecular dynamics of methionine-enkephalin and alpha-endorphin in aqueous solution. Biochemistry 17(14), 2905-14. URL = 79000304 (no abstract available)

Deslauriers, R., E. Ralston & R.L. Somorjai (1977). Conformational studies on angiotensin-II. Least-squares fit of carcon-13 nuclear magnetic resonance relaxation times to extended and folded conformations. J Mol Biol 113(4), 697-710. URL = 77252308 (no abstract available)

Deslauriers, R., R.L. Somorjai & E. Ralston (1977). Correlation between the X-ray structure of melanostatin and its conformation in solution. Nature 266(5604), 746-8. URL = 77213021 (no abstract available)

Somorjai, R.L. & R. Deslauriers (1976). Anisotropic rotational diffusion and intramolecular motion in cyclic amino acids and peptides. An interpretation of 13C spin-lattice relaxation data. J Am Chem Soc 98(21), 6460-7. URL = 77006886 (no abstract available)

Deslauriers, R. & R.L. Somorjai (1976). Internal rotations of side chains and backbone in luteinizing hormone-releasing hormone (LH-RH). Analysis of carbon-13 spin-lattice relaxation times. J Am Chem Soc 98(7), 1931-9. URL = 76143139

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