Dr. Ian C.P. Smith
Associate Professor of Radiology - University of Manitoba
Director General - NRC
Institute for Biodiagnostics
435 Ellice Avenue
Winnipeg, MB Canada R3B 1Y6
Tel (204) 983-7526
Email ibd.research@nrc.ca
Uof M Physics website page http://www.physics.umanitoba.ca/people/adjuncts/smith_i.html
Last Review: December 11, 2002
Biography
Ian C. P. Smith is Director General of the Institute for Biodiagnostics at the National Research Council in Winnipeg. He began his university education at United College (now the University of Winnipeg), 1956-1958. He then obtained a B.Sc. (Hons), 1961, and an M.Sc., 1962, in chemistry at the University of Manitoba, and a Ph.D. (1965) at the University of Cambridge in physical and theoretical chemistry.
After postdoctoral years at Stanford University and Bell Laboratories, he began his career with the National Research Council in Ottawa where he carried out research in applications of complex physical methods to problems of biological and medical significance. He was Director General of the NRC Institute for Biological Sciences, 1987-1992.
In 1992, he returned to Winnipeg to build a new NRC institute, the Institute for Biodiagnostics. His current specialty is early diagnosis of cancer using magnetic resonance imaging and spectroscopy. He is an Adjunct Professor of Physics and Anatomy, and an Associate Professor of Radiology at the University of Manitoba, where he supervises the research of graduate students; he is also an Adjunct Professor of Chemistry at the University of Winnipeg.
He has been honoured by fellowship in the Royal Society of Canada, the Chemical Institute of Canada, and the International Society for Magnetic Resonance in Medicine. He has honorary doctorates from the University of Stockholm, Sweden, the University of Winnipeg, Brandon University, and an honorary diploma from Red River College, Winnipeg. From the Chemical Institute of Canada, he has received the Merck and the Labatt Awards, from the Canadian Biochemical Society the Ayerst Award, and from the Spectroscopy Society of Canada the Barringer and Herzberg Awards. He has received the Flavelle Medal of the Royal Society of Canada.
He is active in international, Canadian, and Winnipeg affairs. He is Chairman of the Manitoba Health Research Council and a member of the Board of Governors, University of Manitoba. He was a member of the General Committee of the International Council of Scientific Unions, and President of the Biophysical Society of Canada. He currently chairs NRC's Committee on International Science, Engineering, and Technology and is Vice President of the International Union of Pure and Applied Biophysics. He is a Member of the Premier of Manitoba's Advisory Board on Economic Development. He sits on the Board of Directors of a number of high tech companies and venture capital firms.
Smith is a strong believer in the interdisciplinary approach to the solution of scientific and medical problems. He has assembled a large team of researchers with a very broad disciplinary base, including physicists, chemists, theoreticians, engineers, biologists, and physicians. His goal is to establish a rational basis for the diagnosis and treatment of disease in humans, and to use this knowledge to advance the state of health and economic viability in Canada.
December, 2002
Publications
Click the URL (Uniform Resource Locator) to view the abstract in the bottom frame.
Smith, I.C.P. and Stewart, L.C (2002). Magnetic resonance spectroscopy in medicine: clinical impact. Prog. Nucl. Magn. Reson. Spectrosc. 40: 1-34.
Lean, C.L., Somorjai, R.L., Smith, I.C.P., Russell, P. and Mountford, C.E. (2002). Accurate diagnosis and prognosis of human cancers by proton MRS and a three stage classification strategy. Ann. Rep. NMR Spectrosc. 48: 71-111.
Bezabeh, T., El-Sayed, S., Patel, R., Somorjai, R.L., Bramwell, V., Kandel, R. and Smith, I.C.P. (2002). Statistical classification strategy for proton magnetic resonance spectra of soft tissue sarcoma: An exploratory study with potential clinical utility. Sarcoma (in press).
El-Sayed, S., T. Bezabeh, O. Odlum, R. Patel, S. Ahing, K. MacDonald, R.L. Somorjai & I.C.P. Smith (2002). An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region. Head Neck 24(8), 766-772. URL = 12203802
Menard, C., I.C.P. Smith, R.L. Somorjai, L. Leboldus, R. Patel, C. Littman, S.J. Robertson & T. Bezabeh (2001). Magnetic resonance spectroscopy of the malignant prostate gland after radiotherapy: a histopathologic study of diagnostic validity. Int J Radiat Oncol Biol Phys 50(2), 317-323. URL = 11380217
Bezabeh, T., M.R. Mowat, L. Jarolim, A.H. Greenberg & I.C.P. Smith (2001). Detection of drug-induced apoptosis and necrosis in human cervical carcinoma cells using 1H NMR spectroscopy. Cell Death Differ 8(3), 219-224. URL = 11319604
Bezabeh, T., R.L. Somorjai, I.C.P. Smith, A.E. Nikulin, B. Dolenko & C.N. Bernstein (2001). The use of 1H magnetic resonance spectroscopy in inflammatory bowel diseases: distinguishing ulcerative colitis from Crohn's disease. Am J Gastroenterol 96(2), 442-448. URL = 11232688
Mountford, C., Somorjai, R., Gluch, L., Malycha, P., Lean, C., Russell, P., Bilous, M., Barraclough, B., Gillett, D., Himmelreich, U., Dolenko, B., NikulinkA and Smith, I. (2001). Diagnosis and prognosis of breast cancer by magnetic resonance spectroscopy of fine-needle aspirates analysed using a statistical classification strategy. Brit. J. Surg. 88: 1234-1240. URL = 11531873
Smith, I.C.P. and Blandford, D.E. (2000). Magnetic resonance in medicine high resolution ex vivo. In Encyclopedia of Analytical Chemistry (Meyers, R.A., Ed.) New York: John Wiley & Sons, 188-201.
Smith, I.C.P. and Bezabeh, T.(2000). Tissue NMR Ex Vivo.
In Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy,
Vol. 2 (Young, I.R., Ed.) Chichester: John Wiley & Sons, 891-898
King, S.B., L.N. Ryner, B. Tomanek, J.C. Sharp & I.C.P. Smith (1999). MR spectroscopy using multi-ring surface coils. Magn Reson Med 42(4), 655-664. URL = 10502753
Krupnik, E., K.M. Briere, R.P. Bird, C. Littman & I.C.P. Smith (1999). 1H magnetic resonance spectroscopy evidence that aberrant crypt foci are preneoplastic lesions in the colon. Anticancer Res 19(3A), 1699-1703. URL = 10470103
Somorjai, R.L., Dolenko, B., Halliday, W., Fewer, D., Hill, N., Ross, I., Brière, K.M. and Smith, I.C.P. (1999). Accurate discrimination between low- and high-grade human brain astrocytomas: robust multivariate analysis of 1H MR spectra. J. Med. Biochem. 3: 17-24.
Zhu, J.M. & I.C.P. Smith (1999). Stimulated anti-echo selection in spatially localized NMR spectroscopy. J Magn Reson 136(1), 1-5. URL = 9887282
Blandford, D.E. & I.C.P. Smith (1998). Magnetic resonance spectroscopy in clinical chemistry: the present and the future. J Int Fed Clin Chem 10(1), 6-8, 11-13. URL = 10181013
Smith, I.C.P. & D.E. Blandford (1998). Diagnosis of cancer in humans by 1H NMR of tissue biopsies. Biochem Cell Biol 76(2-3), 472-476. URL = 9923716
Krupnik, E., Jackson, M., Bird, R.P., Smith, I.C.P. and Mantsch, H.H. (1998). Infrared spectroscopic characteristics of normal and malignant colonic epithelium. Proc. SPIE Int. Soc. Opt. Eng. (Infrared Spectroscopy: New Tool in Medicine) 3257: 307-310.
Wallace, J.C., G.P. Raaphorst, R.L. Somorjai, C.E. Ng, M. Fung Kee Fung, M. Senterman & I.C.P. Smith (1997). Classification of 1H MR spectra of biopsies from untreated and recurrent ovarian cancer using linear discriminant analysis. Magn Reson Med 38(4), 569-576. URL = 9324324
Hahn, P., I.C.P. Smith, L. Leboldus, C. Littman, R.L. Somorjai & T. Bezabeh (1997). The classification of benign and malignant human prostate tissue by multivariate analysis of 1H magnetic resonance spectra. Cancer Res 57(16), 3398-3401. URL = 9270004
Somorjai, R.L., B. Dolenko, A.K. Nikulin, N. Pizzi, G. Scarth, P. Zhilkin, W. Halliday, D. Fewer, N. Hill, I. Ross, M. West, I.C.P. Smith, S.M. Donnelly, A.C. Kuesel & K.M. Briere (1996). Classification of 1H MR spectra of human brain neoplasms: the influence of preprocessing and computerized consensus diagnosis on classification accuracy. J Magn Reson Imaging 6(3), 437-444. URL = 8724408
Kuesel, A.C., K.M. Briere, W.C. Halliday, G.R. Sutherland, S.M. Donnelly & I.C.P. Smith (1996). Mobile lipid accumulation in necrotic tissue of high grade astrocytomas. Anticancer Res 16(3B), 1485-1489. URL = 8694517
Bezabeh, T., I.C.P. Smith, E. Krupnik, R.L. Somorjai, D.G. Kitchen, C.N. Bernstein, N.M. Pettigrew, R.P. Bird, K.J. Lewin & K.M. Briere (1996). Diagnostic potential for cancer via 1H magnetic resonance spectroscopy of colon tissue. Anticancer Res 16(3B), 1553-1558. URL = 8694525
Smith, I.C.P. & D.E. Blandford (1995). Nuclear magnetic resonance spectroscopy. Anal Chem 67(12), 509R-518R. URL = 8686871
Rutter, A., H. Hugenholtz, J.K. Saunders & I.C.P. Smith (1995). One-dimensional phosphorus-31 chemical shift imaging of human brain tumors. Invest Radiol 30(6), 359-366. URL = 7490188
Su, S., J.K. Saunders & I.C.P. Smith (1995). Resolving anatomical details in lung parenchyma: theory and experiment for a structurally and magnetically inhomogeneous lung imaging model. Magn Reson Med 33(6), 760-765. URL = 7651111
Rutter, A., H. Hugenholtz, J.K. Saunders & I.C.P. Smith (1995). Classification of brain tumors by ex vivo 1H MR spectroscopy. J Neurochem 64(4), 1655-1661. URL = 7891093
Briere, K.M., A.C. Kuesel, R.P. Bird & I.C.P. Smith (1995). 1H MR visible lipids in colon tissue from normal and carcinogen-treated rats. Nmr Biomed 8(1), 33-40. URL = 7547183
Wilkins, D.E., G.P. Raaphorst, J.K. Saunders, G.R. Sutherland & I.C.P. Smith (1995). Correlation between Gd-enhanced MR imaging and histopathology in treated and untreated 9L rat brain tumors. Magn Reson Imaging 13(1), 89-96. URL = 7898284
Kuesel, A.C., S.M. Donnelly, W. Halliday, G.R. Sutherland & I.C.P. Smith (1994). Mobile lipids and metabolic heterogeneity of brain tumours as detectable by ex vivo 1H MR spectroscopy. Nmr Biomed 7(4), 172-180. URL = 7946995
Kuesel, A.C., G.R. Sutherland, W. Halliday & I.C.P. Smith (1994). 1H MRS of high grade astrocytomas: mobile lipid accumulation in necrotic tissue. Nmr Biomed 7(3), 149-155. URL = 8080717
Lean, C.L., R.C. Newland, D.A. Ende, E.L. Bokey, I.C.P. Smith & C.E. Mountford (1993). Assessment of human colorectal biopsies by 1H MRS: correlation with histopathology. Magn Reson Med 30(5), 525-533. URL = 8259052
Wilkins, D.E., G.P. Raaphorst, J.K. Saunders & I.C.P. Smith (1993). A new technique for implanting intracranial 9L tumors in rats. Lab Anim Sci 43(5), 518-519. URL = 8277742
Kuesel, A.C., T. Kroft, J.K. Saunders, M. Prefontaine, N. Mikhael & I.C.P. Smith (1992). A simple procedure for obtaining high-quality NMR spectra of semiquantitative value from small tissue specimens: cervical biopsies. Magn Reson Med 27(2), 349-355. URL = 1461119
Kuesel, A.C., T. Kroft, M. Prefontaine & I.C.P. Smith (1992). Lipoprotein(a) and CA125 levels in the plasma of patients with benign and malignant ovarian disease. Int J Cancer 52(3), 341-346. URL = 1399109
Schanck, A., M.P. Mingeot-Leclercq, P.M. Tulkens, D. Carrier, I.C.P. Smith & H.C. Jarrell (1992). Interactions of aminoglycoside antibiotics with phospholipids. A deuterium nuclear magnetic resonance study. Chem Phys Lipids 62(2), 153-163. URL = 1423808
Winsborrow, B.G., J.R. Brisson, I.C.P. Smith & H.C. Jarrell (1992). Influence of the membrane surface on glycolipid conformation and dynamics. An interpretation of NMR results using conformational energy calculations. Biophys J 63(2), 428-437. URL = 1420888
Baenziger, J.E., H.C. Jarrell & I.C.P. Smith (1992). Molecular motions and dynamics of a diunsaturated acyl chain in a lipid bilayer: implications for the role of polyunsaturation in biological membranes. Biochemistry 31(13), 3377-3385. URL = 1554719
Tang, H.L., R.J. Buist, R.H. Rixon, J.F. Whitfield & I.C.P. Smith (1992). Identification of lactate, threonine and alanine in rat thymus and tumorigenic lymphoid cells using 1H 2-D COSY NMR spectroscopy. Nmr Biomed 5(2), 69-74. URL = 1320392
Jasinski, A., T. Jakubowski, M. Rydzy, P. Morris, I.C.P. Smith, P. Kozlowski & J.K. Saunders (1992). Shielded gradient coils and radio frequency probes for high-resolution imaging of rat brains. Magn Reson Med 24(1), 29-41. URL = 1556929
Fenske, D.B., M. Letellier, R. Roy, I.C.P. Smith & H.C. Jarrell (1991). Effect of calcium on the dynamic behavior of sialylglycerolipids and phospholipids in mixed model membranes. A 2H and 31P NMR study. Biochemistry 30(43), 10542-10550. URL = 1931977
de Belle, I., P.R. Walker, I.C.P. Smith & M. Sikorska (1991). Identification of a multiprotein complex interacting with the c-fos serum response element. Mol Cell Biol 11(5), 2752-2759. URL = 1901946
Winsborrow, B.G., I.C.P. Smith & H.C. Jarrell (1991). Dynamics of glycolipids in the liquid-crystalline state. 2H NMR study. Biophys J 59(3), 729-741. URL = 2049527
Baenziger, J.E., H.C. Jarrell, R.J. Hill & I.C.P. Smith (1991). Average structural and motional properties of a diunsaturated acyl chain in a lipid bilayer: effects of two cis-unsaturated double bonds. Biochemistry 30(4), 894-903. URL = 1989684
Prefontaine, M., T. Kroft, M. Monck, J.K. Saunders, N.Z. Mikhael & I.C.P. Smith (1991). Evaluation of a simple line width test involving magnetic resonance spectroscopy of plasma in carcinoma of the ovary. Cancer 67(2), 406-411. URL = 1985735
Auger, M., I.C.P. Smith & H.C. Jarrell (1991). Slow motions in lipid bilayers. Direct detection by two-dimensional solid-state deuterium nuclear magnetic resonance. Biophys J 59(1), 31-38. URL = 2015388
Smith, I.C.P., M. Auger & H.C. Jarrell (1991). Molecular details of anesthetic-lipid interaction. Ann N Y Acad Sci 625, 668-684. URL = 2058915
Czuba, M. & I.C.P. Smith (1991). Biological and NMR markers for cancer. Pharmacol Ther 50(2), 147-190. URL = 1763134
Smith, I.C.P. & H.C. Jarrell (1990). Carbohydrates of the cellular surface: organization and dynamics as seen by 2H N.M.R. Biochem Soc Trans 18(5), 825-827. URL = 2083687 (no abstract available)
Smith, I.C.P. & G.N. Chmurny (1990). NMR spectroscopy and cancer research: the present and the future. Anal Chem 62(15), 853A-859A. URL = 2205124 (no abstract available)
Rydzy, M., R. Deslauriers, I.C.P. Smith & J.K. Saunders (1990). Optimization of magnetization transfer measurements: statistical analysis by stochastic simulation. Application to creatine kinase kinetics. Magn Reson Med 15(2), 260-274. URL = 2392051
Auger, M., M.R. Van Calsteren, I.C.P. Smith & H.C. Jarrell (1990). Glycerolipids: common features of molecular motion in bilayers. Biochemistry 29(24), 5815-5821. URL = 2383559
Baenziger, J.E., I.C.P. Smith & R.J. Hill (1990). Biosynthesis and characterization of a series of deuterated cis,cis-octadeca-6,9-dienoic acids. Chem Phys Lipids 54(1), 17-23. URL = 2361230
Auger, M., I.C.P. Smith, H.H. Mantsch & P.T. Wong (1990). High-pressure infrared study of phosphatidylserine bilayers and their interactions with the local anesthetic tetracaine. Biochemistry 29(8), 2008-2015. URL = 2328235
Smith, I.C.P., E.J. Princz & J.K. Saunders (1990). Magnetic resonance spectroscopy in cancer research. Can Assoc Radiol J 41(1), 32-38. URL = 2178730
Jarrell, H.C. & I.C.P. Smith (1990). NMR of carbohydrates at the surface of cells. Basic Life Sci 56, 303-316. URL = 2078176 (no abstract available)
Awang, D.V., B.A. Dawson, G.A. Neville, I. Ekiel, R. Deslauriers & I.C.P. Smith (1990). 13C-NMR of Rauwolfia alkaloids. J Pharm Biomed Anal 8(1), 91. URL = 2102269 (no abstract available)
Saunders, J.K., I.C.P. Smith, J.C. MacTavish, M. Rydzy, J. Peeling, E. Sutherland, H. Lesiuk & G.R. Sutherland (1989). Forebrain ischemia studied using magnetic resonance imaging and spectroscopy. Nmr Biomed 2(5-6), 312-316. URL = 2641905
Remin, M., R.L. Somorjai, R. Deslauriers, E.J. Princz & I.C.P. Smith (1989). 1H magnetic resonance of human tumours. Analysis of the transverse relaxation of the methylene protons using continuous distributions of relaxation times. Nmr Biomed 2(4), 142-150. URL = 2641495
Deslauriers, R., W.J. Keon, S. Lareau, D. Moir, J.K. Saunders, I.C.P. Smith, K. Whitehead & G.W. Mainwood (1989). Preservation of high-energy phosphates in human myocardium. A phosphorus 31- nuclear magnetic resonance study of the effect of temperature on atrial appendages. J Thorac Cardiovasc Surg 98(3), 402-412. URL = 2770321
Carrier, D., J.B. Giziewicz, D. Moir, I.C.P. Smith & H.C. Jarrell (1989). Dynamics and orientation of glycolipid headgroups by 2H-NMR: gentiobiose. Biochim Biophys Acta 983(1), 100-108. URL = 2758044
Auger, M., I.C.P. Smith & H.C. Jarrell (1989). Interactions of the local anesthetic tetracaine with glyceroglycolipid bilayers: a 2H-NMR study. Biochim Biophys Acta 981(2), 351-357. URL = 2730911
Renou, J.P., J.B. Giziewicz, I.C.P. Smith & H.C. Jarrell (1989). Glycolipid membrane surface structure: orientation, conformation, and motion of a disaccharide headgroup. Biochemistry 28(4), 1804-1814. URL = 2719936
Smith, I.C.P. (1989). Magnetic resonance spectroscopy in biology and medicine. Clin Biochem 22(1), 69-76. URL = 2706776
Smith, I.C.P., J. Baenziger, M. Auger & H.C. Jarrell (1989). Deuterium NMR as a monitor of organization and dynamics at the surface of membranes: the glycolipids. Prog Clin Biol Res 292, 13-22. URL = 2657764 (no abstract available)
Smith, I.C.P., M. Auger & H.C. Jarrell (1989). Structure and dynamics of the glycolipid components of membrane receptors: 2H NMR provides a route to in vivo observation. Ann N Y Acad Sci 568, 44-51. URL = 2629586 (no abstract available).
Saunders, J.K., I.C.P. Smith, J.C. MacTavish, M. Rydzy, J. Peeling, E. Sutherland, H. Lesiuk & G.R. Sutherland (1989). Forebrain ischemia studied using magnetic resonance imaging and spectroscopy. NMR. Biomed. 2(5-6), 312-316. URL = Medline AN: 90373605.
Stewart, L.C., M. Kates & I.C.P. Smith (1988). Synthesis and characterization of deoxy analogues of diphytanylglycerol phospholipids. Chem Phys Lipids 48(3-4), 177-188. URL = 3242946
Auger, M., H.C. Jarrell, I.C.P. Smith, D.J. Siminovitch, H.H. Mantsch & P.T. Wong (1988). Effects of the local anesthetic tetracaine on the structural and dynamic properties of lipids in model membranes: a high-pressure Fourier transform infrared study. Biochemistry 27(16), 6086-6093. URL = 3191108
Auger, M., H.C. Jarrell & I.C.P. Smith (1988). Interactions of the local anesthetic tetracaine with membranes containing phosphatidylcholine and cholesterol: a 2H NMR study. Biochemistry 27(13), 4660-4667. URL = 3167009
Geoffrion, Y., M. Rydzy, K.W. Butler, I.C.P. Smith & H.C. Jarrell (1988). The use of immobilized ferrite to enhance the depth selectivity of in vivo surface coil NMR spectroscopy. Nmr Biomed 1(3), 107-112. URL = 3275121
Ekiel, I.H., L. Hughes, G.W. Burton, P.A. Jovall, K.U. Ingold & I.C.P. Smith (1988). Structure and dynamics of alpha-tocopherol in model membranes and in solution: a broad-line and high-resolution NMR study. Biochemistry 27(5), 1432-1440. URL = 3365398
Deslauriers, R., R.L. Somorjai, Y. Geoffrion, T. Kroft, I.C.P. Smith & J.K. Saunders (1988). 1H and 13C NMR studies of tissue from normal and diseased mice. Analysis of T1 and T2 relaxation profiles of triglycerides in liver. Nmr Biomed 1(1), 32-43. URL = 3079286
Auger, M., H.C. Jarrell, I.C.P. Smith, P.T. Wong, D.J. Siminovitch & H.H. Mantsch (1987). Pressure-induced exclusion of a local anesthetic from model and nerve membranes. Biochemistry 26(26), 8513-8516. URL = 3442673
Deslauriers, R., K. Butler & I.C.P. Smith (1987). Oxidant stress in malaria as probed by stable nitroxide radicals in erythrocytes infected with Plasmodium berghei. The effects of primaquine and chloroquine. Biochim Biophys Acta 931(3), 267-275. URL = 3315005
Jarrell, H.C., P.A. Jovall, J.B. Giziewicz, L.A. Turner & I.C.P. Smith (1987). Determination of conformational properties of glycolipid head groups by 2H NMR of oriented multibilayers. Biochemistry 26(7), 1805-1811. URL = 3593692
Jarrell, H.C., A.J. Wand, J.B. Giziewicz & I.C.P. Smith (1987). The dependence of glyceroglycolipid orientation and dynamics on head-group structure. Biochim Biophys Acta 897(1), 69-82. URL = 3801482
Dufourc, E.J., I.C.P. Smith & J. Dufourcq (1986). Molecular details of melittin-induced lysis of phospholipid membranes as revealed by deuterium and phosphorus NMR. Biochemistry 25(21), 6448-6455. URL = 3790532
Dufourc, E.J. & I.C.P. Smith (1986). A detailed analysis of the motions of cholesterol in biological membranes by 2H-NMR relaxation. Chem Phys Lipids 41(2), 123-135. URL = 3779887
Hill, R.J., T. Kroft, M. Zuker & I.C.P. Smith (1986). Large-scale selection synchrony of Tetrahymena thermophila. J Cell Sci 84, 237-251. URL = 3805154
Deslauriers, R., D.J. Moffatt & I.C.P. Smith (1986). Oxygen consumption in Plasmodium berghei-infected murine red cells: a direct spectrophotometric assay in intact erythrocytes. Biochim Biophys Acta 886(3), 319-326. URL = 3518808
Ekiel, I., G.D. Sprott & I.C.P. Smith (1986). Mevalonic acid is partially synthesized from amino acids in Halobacterium cutirubrum: a 13C nuclear magnetic resonance study. J Bacteriol 166(2), 559-564. URL = 3700337
Butler, K.W., R. Deslauriers & I.C.P. Smith (1986). Effects of antimalarial drugs on oxygen consumption by erythrocytes infected with Plasmodium berghei: an ESR study. Magn Reson Med 3(2), 312-316. URL = 3012241
Kelusky, E.C., Y. Boulanger, S. Schreier & I.C.P. Smith (1986). A 2H-NMR study on the interactions of the local anesthetic tetracaine with membranes containing phosphatidylserine. Biochim Biophys Acta 856(1), 85-90. URL = 3955036
Mountford, C.E., J.K. Saunders, G.L. May, K.T. Holmes, P.G. Williams, R.M. Fox, M.H. Tattersall, J.R. Barr, P. Russell & I.C.P. Smith (1986). Classification of human tumours by high-resolution magnetic resonance spectroscopy. Lancet 1(8482), 651-653. URL = 2869350
May, G.L., L.C. Wright, K.T. Holmes, P.G. Williams, I.C.P. Smith, P.E. Wright, R.M. Fox & C.E. Mountford (1986). Assignment of methylene proton resonances in NMR spectra of embryonic and transformed cells to plasma membrane triglyceride. J Biol Chem 261(7), 3048-3053. URL = 3949759
Burton, G.W., D.O. Foster, B. Perly, T.F. Slater, I.C.P. Smith & K.U. Ingold (1985). Biological antioxidants. Philos Trans R Soc Lond B Biol Sci 311(1152), 565-578. URL = 2869517
Perly, B., I.C.P. Smith, L. Hughes, G.W. Burton & K.U. Ingold (1985). Estimation of the location of natural alpha-tocopherol in lipid bilayers by 13C-NMR spectroscopy. Biochim Biophys Acta 819(1), 131-135. URL = 4041449
Perly, B., I.C.P. Smith & H.C. Jarrell (1985). Acyl chain dynamics of phosphatidylethanolamines containing oleic acid and dihydrosterculic acid: 2H NMR relaxation studies. Biochemistry 24(17), 4659-4665. URL = 4063348
Geoffrion, Y., K. Butler, M. Pass, I.C.P. Smith & R. Deslauriers (1985). Plasmodium berghei: gluconeogenesis in the infected mouse liver studied by 13C nuclear magnetic resonance. Exp Parasitol 59(3), 364-374. URL = 3888649
Butler, K.W., R. Deslauriers, Y. Geoffrion, J.M. Storey, K.B. Storey, I.C.P. Smith & R.L. Somorjai (1985). 31P nuclear magnetic resonance studies of crayfish (Orconectes virilis). The use of inversion spin transfer to monitor enzyme kinetics in vivo. Eur J Biochem 149(1), 79-83. URL = 3996405
Dufourc, E.J. & I.C.P. Smith (1985). 2H NMR evidence for antibiotic-induced cholesterol immobilization in biological model membranes. Biochemistry 24(10), 2420-2424. URL = 4016066
Perly, B., I.C.P. Smith & H.C. Jarrell (1985). Effects of replacement of a double bond by a cyclopropane ring in phosphatidylethanolamines: a 2H NMR study of phase transitions and molecular organization. Biochemistry 24(4), 1055-1063. URL = 3994990
Geoffrion, Y., S. Lareau, R. Deslauriers, K. Butler, M. Pass & I.C.P. Smith (1985). A versatile perfusion technique for metabolic studies by NMR. Magn Reson Med 2(1), 65-72. URL = 3831678
Deslauriers, R., Y. Geoffrion, K.W. Butler & I.C.P. Smith (1985). Magnetic resonance studies of the pathophysiology of murine malaria. Q Rev Biophys 18(1), 65-110. URL = 2999860 (no abstract available)
Dufourc, E.J., I.C.P. Smith & H.C. Jarrell (1984). Interaction of amphotericin B with membrane lipids as viewed by 2H-NMR. Biochim Biophys Acta 778(3), 435-442. URL = 6509046
Pass, M.A., Y. Geoffrion, R. Deslauriers, K.W. Butler & I.C.P. Smith (1984). Use of 13C nuclear magnetic resonance spectroscopy for the evaluation of hepatic drug-metabolizing enzyme activity in perfused mouse livers. J Biochem Biophys Methods 10(3-4), 135-142. URL = 6397498
Dufourc, E.J., I.C.P. Smith & H.C. Jarrell (1984). Amphotericin and model membranes. The effect of amphotericin B on cholesterol-containing systems as viewed by 2H-NMR. Biochim Biophys Acta 776(2), 317-329. URL = 6477913
Mountford, C.E., W.B. Mackinnon, M. Bloom, E.E. Burnell & I.C.P. Smith (1984). NMR methods for characterizing the state of the surfaces of complex mammalian cells. J Biochem Biophys Methods 9(4), 323-330. URL = 6491154
Kelusky, E.C. & I.C.P. Smith (1984). The influence of local anesthetics on molecular organization in phosphatidylethanolamine membranes. Mol Pharmacol 26(2), 314-321. URL = 6482876
Storey, K.B., M. Miceli, K.W. Butler, I.C.P. Smith & R. Deslauriers (1984). 31P-NMR studies of the freeze-tolerant larvae of the gall fly, Eurosta solidaginis. Eur J Biochem 142(3), 591-595. URL = 6468382
Kelusky, E.C. & I.C.P. Smith (1984). Anesthetic-membrane interaction: a 2H nuclear magnetic resonance study of the binding of specifically deuterated tetracaine and procaine to phosphatidylcholine. Can J Biochem Cell Biol 62(4), 178-184. URL = 6722635
Butler, K.W., R. Deslauriers & I.C.P. Smith (1984). Plasmodium berghei: electron spin resonance and lipid analysis of infected mouse erythrocyte membranes. Exp Parasitol 57(2), 178-184. URL = 6325227
Kelusky, E.C. & I.C.P. Smith (1983). Characterization of the binding of the local anesthetics procaine and tetracaine to model membranes of phosphatidylethanolamine: a deuterium nuclear magnetic resonance study. Biochemistry 22(25), 6011-6017. URL = 6661422
Kelusky, E.C., E.J. Dufourc & I.C.P. Smith (1983). Direct observation of molecular ordering of cholesterol in human erythrocyte membranes. Biochim Biophys Acta 735(2), 302-304. URL = 6688740
Ekiel, I., I.C.P. Smith & G.D. Sprott (1983). Biosynthetic pathways in Methanospirillum hungatei as determined by 13C nuclear magnetic resonance. J Bacteriol 156(1), 316-326. URL = 6619097
Taylor, M.G. & I.C.P. Smith (1983). The conformations of nitroxide-labelled fatty acid probes of membrane structure as studied by 2H-NMR. Biochim Biophys Acta 733(2), 256-263. URL = 6309230
Dufourc, E.J., I.C.P. Smith & H.C. Jarrell (1983). A 2H-NMR analysis of dihydrosterculoyl-containing lipids in model membranes: structural effects of a cyclopropane ring. Chem Phys Lipids 33(2), 153-177. URL = 6627531
Marsh, D., A. Watts & I.C.P. Smith (1983). Dynamic structure and phase behavior of dimyristoylphosphatidylethanolamine bilayers studied by deuterium nuclear magnetic resonance. Biochemistry 22(12), 3023-3026. URL = 6871183
Fournier, N.C., M. Zuker, R.E. Williams & I.C.P. Smith (1983). Self-association of the cardiac fatty acid binding protein. Influence on membrane-bound, fatty acid dependent enzymes. Biochemistry 22(8), 1863-1872. URL = 6303395
Deslauriers, R., I. Ekiel, T. Kroft & I.C.P. Smith (1982). NMR studies of malaria. 31P nuclear magnetic resonance of blood from mice infected with Plasmodium berghei. Biochim Biophys Acta 721(4), 449-457. URL = 6760901
Taylor, M.G., T. Akiyama, H. Saito & I.C.P. Smith (1982). Direct observation of the properties of cholesterol in membranes by deuterium NMR. Chem Phys Lipids 31(4), 359-379. URL = 7160030
Deslauriers, R., I. Ekiel, R.A. Byrd, H.C. Jarrell & I.C.P. Smith (1982). A 31P-NMR study of structural and functional aspects of phosphate and phosphonate distribution in Tetrahymena. Biochim Biophys Acta 720(4), 329-337. URL = 7115775
Jarrell, H.C., K.W. Butler, R.A. Byrd, R. Deslauriers, I. Ekiel & I.C.P. Smith (1982). A 2H-NMR study of Acholeplasma laidlawii membranes highly enriched in myristic acid. Biochim Biophys Acta 688(2), 622-636. URL = 7104342
Rance, M., K.R. Jeffrey, A.P. Tulloch, K.W. Butler & I.C.P. Smith (1982). Effects of cholesterol on the orientational order of unsaturated lipids in the membranes of Acholeplasma laidlawii. A 2H-NMR study. Biochim Biophys Acta 688(1), 191-200. URL = 7093275
Westman, J., Y. Boulanger, A. Ehrenberg & I.C.P. Smith (1982). Charge and pH dependent drug binding to model membranes. A 2H-NMR and light absorption study. Biochim Biophys Acta 685(3), 315-328. URL = 7199938
Aracava, Y., S. Schreier, R. Phadke, R. Deslauriers & I.C.P. Smith (1981). Effects of amphotericin B on membrane permeability--kinetics of spin probe reduction. Biophys Chem 14(4), 325-332. URL = 6279197
Boulanger, Y., S. Schreier & I.C.P. Smith (1981). Molecular details of anesthetic--lipid interaction as seen by deuterium and phosphorus-31 nuclear magnetic resonance. Biochemistry 20(24), 6824-6830. URL = 6895602 (no abstract available)
Aracava, Y., I.C.P. Smith & S. Schreier (1981). Effect of amphotericin B on membranes: a spin probe study. Biochemistry 20(20), 5702-5707. URL = 6271190
Taylor, M.G. & I.C.P. Smith (1981). Reliability of nitroxide spin probes in reporting membrane properties: a comparison of nitroxide- and deuterium-labeled steroids. Biochemistry 20(18), 5252-5255. URL = 6271181
Aracava, Y., S. Schreier, R. Phadke, R. Deslauriers & I.C.P. Smith (1981). Spin label reduction kinetics, a procedure to study the effect of drugs on membrane permeability: the effects of monosodium urate, dimethyl sulfoxide and amphotericin B. J Biochem Biophys Methods 5(2), 83-94. URL = 6268683
Cameron, D.G., H.L. Casal, H.H. Mantsch, Y. Boulanger & I.C.P. Smith (1981). The thermotropic behavior of dipalmitoyl phosphatidylcholine bilayers. A Fourier transform infrared study of specifically labeled lipids. Biophys J 35(1), 1-16. URL = 6894878
Neurohr, K.J., N.M. Young, I.C.P. Smith & H.H. Mantsch (1981). Kinetics of binding of methyl alpha- and beta-D-galactopyranoside to peanut agglutinin: a carbon-13 nuclear magnetic resonance study. Biochemistry 20(12), 3499-3504. URL = 7260053
Jarrell, H.C., R.A. Byrd & I.C.P. Smith (1981). Analysis of the composition of mixed lipid phases by the moments of 2H NMR spectra. Biophys J 34(3), 451-463. URL = 7018609 (no abstract available)
Ekiel, I., D. Marsh, B.W. Smallbone, M. Kates & I.C.P. Smith (1981). The state of the lipids in the purple membrane of Halobacterium cutirubrum as seen by 31P NMR. Biochem Biophys Res Commun 100(1), 105-110. URL = 7259737 (no abstract available)
Kushwaha, S.C., M. Kates, G.D. Sprott & I.C.P. Smith (1981). Novel polar lipids from the methanogen Methanospirillum hungatei GP1. Biochim Biophys Acta 664(1), 156-173. URL = 7236696
Kushwaha, S.C., M. Kates, G.D. Sprott & I.C.P. Smith (1981). Novel complex polar lipids from the methanogenic archaebacterium Methanospirillum hungatei. Science 211(4487), 1163-1164. URL = 7466385
Neurohr, K.J., N. Lacelle, H.H. Mantsch & I.C.P. Smith (1980). Molecular dynamics of sugars bound to wheat germ agglutinin, as studied by deuterium nuclear magnetic resonance. Biophys J 32(3), 931-938. URL = 6894877
Deslauriers, R., H.C. Jarrell, D.W. Griffith, W.H. McGregor & I.C.P. Smith (1980). Degradation of enkephalin and enkephalinamide by neuroblastoma x glioma hybrid cells as studied by 13C N.M.R. Int J Pept Protein Res 16(5), 487-493. URL = 7216624
Deslauriers, R., R.A. Byrd, H.C. Jarrell & I.C.P. Smith (1980). 31P NMR studies of vegetative and encysted cells of Acanthamoeba castellanii. Observation of phosphonic acids in live cells. Eur J Biochem 111(2), 369-375. URL = 7460902
Boulanger, Y., S. Schreier, L.C. Leitch & I.C.P. Smith (1980). Multiple binding sites for local anesthetics in membranes: characterization of the sites and their equilibria by deuterium NMR of specifically deuterated procaine and tetracaine. Can J Biochem 58(10), 986-995. URL = 6257349
Deslauriers, R., H.C. Jarrell, R.A. Byrd & I.C.P. Smith (1980). Observation by 13C NMR of metabolites in differentiating amoeba. Trehalose storage in encysted Acanthamoeba castellanii. Febs Lett 118(2), 185-190. URL = 7418869 (no abstract available)
Deslauriers, R., H.C. Jarrell, R.A. Byrd & I.C.P. Smith (1980). 31P NMR studies of metabolism in Acanthamoeba castellanii: polyphosphate release from encysted cells. Biochem Biophys Res Commun 95(3), 1211-1217. URL = 7417309 (no abstract available)
Rance, M., K.R. Jeffrey, A.P. Tulloch, K.W. Butler & I.C.P. Smith (1980). Orientational order of unsaturated lipids in the membranes of Acholeplasma laidlawii as observed by 2H-NMR. Biochim Biophys Acta 600(2), 245-262. URL = 7407113
Taylor, M.G. & I.C.P. Smith (1980). The fidelity of response by nitroxide spin probes to changes in membrane organization: the condensing effect of cholesterol. Biochim Biophys Acta 599(1), 140-149. URL = 7397144 (no abstract available)
Davis, J.H., M. Bloom, K.W. Butler & I.C.P. Smith (1980). The temperature dependence of molecular order and the influence of cholesterol in Acholeplasma laidlawii membranes. Biochim Biophys Acta 597(3), 477-491. URL = 6892886
Delmelle, M., K.W. Butler & I.C.P. Smith (1980). Saturation transfer electron spin resonance spectroscopy as a probe of anisotropic motion in model membrane systems. Biochemistry 19(4), 698-704. URL = 6243954 (no abstract available)
Casal, H.L., D.G. Cameron, I.C.P. Smith & H.H. Mantsch (1980). Acholeplasma laidlawii membranes: a Fourier transform infrared study of the influence of protein on lipid organization and dynamics. Biochemistry 19(3), 444-451. URL = 6892608
Jarrell, H.C., R. Deslauriers, W.H. McGregor & I.C.P. Smith (1980). Interaction of opioid peptides with model membranes. A carbon-13 nuclear magnetic study of enkephalin binding to phosphatidylserine. Biochemistry 19(2), 385-390. URL = 6243479
Colson, P., H.C. Jarrell, B.L. Lamberts & I.C.P. Smith (1979). Determination, by carbon-13 nuclear magnetic resonance spectroscopy, of the composition of glucans synthesized by enzymes of the cariogenic organism Streptococcus mutans. Carbohydr Res 71, 265-272. URL = 455337
Deslauriers, R., I.C.P. Smith, R.L. Somorjai, E. Ralston, R.C. Orlowski & R. Walter (1979). Effects of D and L amino acid residues in linear peptides on carbon-13 nuclear magnetic resonance parameters. Int J Pept Protein Res 13(5), 473-478. URL = 38217
Smith, I.C.P., K.W. Butler, A.P. Tulloch, J.H. Davis & M. Bloom (1979). The properties of gel state lipid in membranes of Acholeplasma laidlawii as observed by 2H NMR. Febs Lett 100(1), 57-61. URL = 437110 (no abstract available)
Casal, H.L., I.C.P. Smith, D.G. Cameron & H.H. Mantsch (1979). Lipid reorganization in biological membranes: a study by Fourier transform infrared difference spectroscopy. Biochim Biophys Acta 550(1), 145-149. URL = 760788
Smith, I.C.P. (1979). The Ayerst Award Lecture 1978. Organization and dynamics of membrane lipids as determined by magnetic resonance spectroscopy. Can J Biochem 57(1), 1-14. URL = 218704
Deslauriers, R., I.C.P. Smith, G.L. Stahl & R. Walter (1979). Studies of the interaction of bovine neurophysin-II with. Int J Pept Protein Res 13(1), 78-87. URL = 33931 (no abstract available)
Matsch, H.H. & I.C.P. Smith (1979). Carbon-13 nuclear magnetic resonance spectroscopy of the vitamin B6 group. Methods Enzymol 62, 422-435. URL = 440124 (no abstract available)
Schreier, S., C.F. Polnaszek & I.C.P. Smith (1978). Spin labels in membranes. Problems in practice. Biochim Biophys Acta 515(4), 395-436. URL = 215206 (no abstract available)
Westerik, J.O., B. Sarkar, R. Deslauriers & I.C.P. Smith (1978). The loci of binding of the specific inhibitors methanol and aniline to bovine carbonic anhydrase. J Biol Chem 253(23), 8499-8506. URL = 101546 (no abstract available)
Walter, R., R. Deslauriers & I.C.P. Smith (1978). Aggregation of Pro-Leu-Gly-NH2 in aqueous solution. Febs Lett 95(2), 357-360. URL = 31304 (no abstract available)
Butler, K.W., K.G. Johnson & I.C.P. Smith (1978). Acholeplasma laidlawii membranes: an electron spin resonance study of the influence on molecular order of fatty acid composition and cholesterol. Arch Biochem Biophys 191(1), 289-297. URL = 216314 (no abstract available)
Deslauriers, R., F. Hasan, B.A. Lodge & I.C.P. Smith (1978). Assignment by 13-C-NMR spectroscopy of configuration at C-5 in 17 alpha-ethylestran-17 beta-ol, an impurity in the anabolic steroid ethylestrenol. J Pharm Sci 67(8), 1187-1189. URL = 671267
Tancrede, P., R. Deslauriers, W.H. McGregor, E. Ralston, D. Sarantakis, R.L. Somorjai & I.C.P. Smith (1978). A carbon-13 nuclear magnetic resonance study of the molecular dynamics of methionine-enkephalin and alpha-endorphin in aqueous solution. Biochemistry 17(14), 2905-2914. URL = 687568 (no abstract available)
Butler, K.W. & I.C.P. Smith (1978). Sterol ordering effects and permeability regulation in phosphatidylcholine bilayers. A comparison of ESR spin-probe data from oriented multilamellae and dispersions. Can J Biochem 56(2), 117-122. URL = 204400
Smith, I.C.P., A.P. Tulloch, G.W. Stockton, S. Schreier, A. Joyce, W. Butler, Y. Boulanger, B. Blackwell & L.G. Bennett (1978). Determination of membrane properties at the molecular level by carbon-13 and deuterium magnetic resonance. Ann N Y Acad Sci 308, 8-28. URL = 279301 (no abstract available)
Jennings, H.J. & I.C.P. Smith (1978). Polysaccharide structures using carbon-13 nuclear magnetic resonance. Methods Enzymol 50, 39-50. URL = 661595 (no abstract available)
Jennings, H.J., A.K. Bhattacharjee, D.R. Bundle, C.P. Kenny, A. Martin & I.C.P. Smith (1977). Strucutres of the capsular polysaccharides of Neisseria meningitidis as determined by 13C-nuclear magnetic resonance spectroscopy. J Infect Dis 136 Suppl, S78-83. URL = 408435
Deslauriers, R. & I.C.P. Smith (1977). Intramolecular and overall motion of proline: the influence of viscosity on carbon-13 spin-lattice relaxation times. Biopolymers 16(6), 1245-1257. URL = 195643 (no abstract available)
Deslauriers, R., G.C. Levy, W.H. McGregor, D. Sarantakis & I.C.P. Smith (1977). The influence of glycyl residues on the flexibility of peptide hormones in solution. A 13C-nuclear-magnetic-resonance study of luteinizing hormone-releasing hormone (luliberin) and its des-glycinamide10 N-ethylamide analog. Eur J Biochem 75(2), 343-346. URL = 328272
Neville, G.A., F.B. Hasan & I.C.P. Smith (1977). Quantitative analysis of degradation products in pilocarpine hydrochloride ophthalmic formulations. J Pharm Sci 66(5), 638-642. URL = 17713
Deslauriers, R., R.A. Komoroski, G.C. Levy, J.H. Seely & I.C.P. Smith (1976). A carbon-13 nuclear magnetic resonance study of hyperactive and hypoactive derivatives of luteinizing hormone-releasing hormone: des-Gly-NH2(10)-[DLeu6]LH-RH ethylamide and des-Gly-NH2(10)-[L-Leu6]LH-RH ethylamide. Biochemistry 15(21), 4672-4675. URL = 788780
Stockton, G.W. & I.C.P. Smith (1976). A deuterium nuclear magnetic resonance study of the condensing effect of cholesterol on egg phosphatidylcholine bilayer membranes. I. Perdeuterated fatty acid probes. Chem Phys Lipids 17(2-3 SPEC NO), 251-263. URL = 1033045
Stockton, G.W., C.F. Polnaszek, A.P. Tulloch, F. Hasan & I.C.P. Smith (1976). Molecular motion and order in single-bilayer vesicles and multilamellar dispersions of egg lecithin and lecithin-cholesterol mixtures. A deuterium nuclear magnetic resonance study of specifically labeled lipids. Biochemistry 15(5), 954-966. URL = 943179
Deslauriers, R., R.A. Komoroski, G.C. Levy, A.C. Paiva & I.C.P. Smith (1976). Conformational heterogeneity in linear peptides in solution: a carbon-1 3 NMR study of (Pro3, Pro5)-angiotensin-II. Febs Lett 62(1), 50-56. URL = 2504 (no abstract available)
Schleich, T., B.P. Cross & I.C.P. Smith (1976). A conformational study of adenylyl-(3',5')-adenosine and adenylyl-(2',5')-adenosine in aqueous solution by carbon-13 magnetic resonance spectroscopy. Nucleic Acids Res 3(2), 355-370. URL = 1257051
Schreier-Muccillo, S., D. Marsh & I.C.P. Smith (1976). Monitoring the permeability profile of lipid membranes with spin probes. Arch Biochem Biophys 172(1), 1-11. URL = 175738
Neal, M.J., K.W. Butler, C.F. Polnaszek & I.C.P. Smith (1976). The influence of anesthetics and cholesterol on the degree of molecular organization and mobility of ox brain white matter. Lipids in multibilayer membranes: a spin probe study using spectral simulation by the stochastic method. Mol Pharmacol 12(1), 144-155. URL = 1256440 (no abstract available)
Bhattacharjee, A.K., H.J. Jennings, C.P. Kenny, A. Martin & I.C.P. Smith (1976). Structural determination of the polysaccharide antigens of Neisseria meningitidis serogroups Y, W-135, and BO1. Can J Biochem 54(1), 1-8. URL = 814976
Smith, I.C.P. & R. Deslauriers (1976). Carbon-13 nuclear magnetic resonance investigations of hormone structure and function. Recent Prog Horm Res 33, 309-332. URL = 801193
Deslauriers, R., G.C. Levy, W.H. McGregor, K. Sarantakis & I.C.P. Smith (1975). Conformational flexibility of luteinizing hormone-releasing hormone in aqueous solution. A carbon-13 spin-lattice relaxation time study. Biochemistry 14(19), 4335-4343. URL = 170960
Stockton, G.W., K.G. Johnson, K.W. Butler, C.F. Polnaszek, R. Cyr & I.C.P. Smith (1975). Molecular order in Acholeplasma laidlawii membranes as determined by deuterium magnetic resonance of biosynthetically-incorporated specifically-labelled lipids. Biochim Biophys Acta 401(3), 535-539. URL = 1182151
Cannon, B., C.F. Polnaszek, K.W. Butler, L.E. Eriksson & I.C.P. Smith (1975). The fluidity and organization of mitochondrial membrane lipids of the brown adipose tissue of cold-adapted rats and hamsters as determined by nitroxide spin probes. Arch Biochem Biophys 167(2), 505-518. URL = 164831 (no abstract available)
Deslauriers, R., A.C. Paiva, K. Schaumburg & I.C.P. Smith (1975). Conformational flexibility of angiotensin II. A carbon-13 spin-lattice relaxation study. Biochemistry 14(5), 878-886. URL = 164885
Bhattacharjee, A.K., H.J. Jennings, C.P. Kenny, A. Martin & I.C.P. Smith (1975). Structural determination of the sialic acid polysaccharide antigens of Neisseria meningitidis serogroups B and C with carbon 13 nuclear magnetic resonance. J Biol Chem 250(5), 1926-1932. URL = 163259
Colson, P., H.J. Jennings & I.C.P. Smith (1974). Composition, sequence, and conformation of polymers and oligomers of glucose as revealed by carbon-13 nuclear magentic resonance. J Am Chem Soc 96(26), 8081-8087. URL = 4464319 (no abstract available)
Deslauriers, R., I.C.P. Smith & R. Walter (1974). Conformational mobility of the pyrrolidine ring of proline in peptides and peptide hormones as manifest in carbon 13 spin-lattice relaxation times. J Biol Chem 249(21), 7006-7010. URL = 4371430 (no abstract available)
Stanacev, N.Z., L. Stuhne-Sekalec, S. Schreier-Muccillo & I.C.P. Smith (1974). Biosynthesis of spin-labelled lipids and their use in the study of biological membranes: isolation and characterization of membrane-bound spin-labelled sn-3-phosphatidic acid-2-3H prepared by enzymatic incorporation of spin-labelled stearic acid into sn-glycero-3-phosphate-2-3H. Can J Biochem 52(10), 884-893. URL = 4371923 (no abstract available)
Stockton, G.W., C.F. Polnaszek, L.C. Leitch, A.P. Tulloch & I.C.P. Smith (1974). A study of mobility and order in model membranes using 2H NMR relaxation rates and quadrupole splittings of specifically deuterated lipids. Biochem Biophys Res Commun 60(2), 844-850. URL = 4473154 (no abstract available)
Butler, K.W., N.H. Tattrie & I.C.P. Smith (1974). The location of spin probes in two phase mixed lipid systems. Biochim Biophys Acta 363(3), 351-360. URL = 4376694 (no abstract available)
Deslauriers, R., W.H. McGregor, D. Sarantakis & I.C.P. Smith (1974). Carbon-13 nuclear magnetic resonance studies of structure and function in thyrotropin-releasing factor. Determination of the tautomeric form of histidine and relationship to biology activity. Biochemistry 13(17), 3443-3448. URL = 4211032 (no abstract available)
Saito, H. & I.C.P. Smith (1974). Carbon-13 spin-lattice relaxation studies of intramolecular motion in lysine and a series of oligolysines. Arch Biochem Biophys 163(2), 699-704. URL = 4369827 (no abstract available)
Mailer, C., C.P. Taylor, S. Schreier-Muccillo & I.C.P. Smith (1974). The influence of cholesterol on molecular motion in egg lecithin bilayers--a variable-frequency electron spin resonance study of a cholestane spin probe. Arch Biochem Biophys 163(2), 671-678. URL = 4370474 (no abstract available)
Walter, R., I.C.P. Smith & R. Deslauriers (1974). The conformation of oxytocin in dimethylsulfoxide as revealed by carbon-13 spin-lattice relaxation times. Biochem Biophys Res Commun 58(1), 216-221. URL = 4364616 (no abstract available)
Verma, S.P., H. Schneider & I.C.P. Smith (1974). Effects of visual pigments on the organization of phospholipid multibilayer model membranes--a spin probe study. Arch Biochem Biophys 162(1), 48-55. URL = 4364699 (no abstract available)
Verma, S.P., D.F. Wallach & I.C.P. Smith (1974). The action of melittin on phosphatide multibilayers as studied by infrared dichroism and spin labeling. A model approach to lipid-protein interactions. Biochim Biophys Acta 345(1), 129-140. URL = 4365064 (no abstract available)
Bundle, D.R., I.C.P. Smith & H.J. Jennings (1974). Determination of the structure and conformation of bacterial polysaccharides by carbon 13 nuclear magnetic resonance. Studies on the group-specific antigens of Neisseria meningitidis serogroups A and X. J Biol Chem 249(7), 2275-2281. URL = 4206552 (no abstract available)
Deslauriers, R., R. Walter & I.C.P. Smith (1974). Long-range, pH-dependent effects on the carbon-13 nuclear magnetic resonance spectra of oxytocin. Proc Natl Acad Sci U S a 71(2), 265-268. URL = 4521798 (no abstract available)
Smith, I.C.P., R. Deslauriers, H. Saito, R. Walter, C. Garrigou-Lagrange, H. McGregor & D. Sarantakis (1973). Carbon-13 NMR studies of peptide hormones and their components. Ann N Y Acad Sci 222, 597-627. URL = 4361873 (no abstract available)
Verma, S.P., L.J. Berliner & I.C.P. Smith (1973). Cation-dependent light-induced structural changes in visual receptor membranes. Biochem Biophys Res Commun 55(3), 704-709. URL = 4357429 (no abstract available)
Deslauriers, R., R. Walter & I.C.P. Smith (1973). Intramolecular motion in peptide determined by 13C NMR: a spin-lattice relaxation time-study on MSH-release-inhibiting factor. Febs Lett 37(1), 27-32. URL = 4585031 (no abstract available)
Schreier-Muccillo, S., K.W. Butler & I.C.P. Smith (1973). Structural requirements for the formation of ordered lipid multibilayers--a spin probe study. Arch Biochem Biophys 159(1), 297-311. URL = 4361549 (no abstract available)
Govil, G. & I.C.P. Smith (1973). A carbon-13 magnetic resonance study of the helix-coil transition in polyuridylic acid. Biopolymers 12(11), 2589-2598. URL = 4780720 (no abstract available)
Saito, H. & I.C.P. Smith (1973). Carbon-13 nuclear magnetic resonance studies of polyamino acids: the helix-coil transition of poly-L-lysine. Arch Biochem Biophys 158(1), 154-163. URL = 4729292 (no abstract available)
Deslauriers, R., R. Walter & I.C.P. Smith (1973). 13C nuclear magnetic resonance studies of the conformation of the X-pro bond in the oligopeptide hormones, thyrotropin-releasing hormone, luteinizing hormone-releasing factor, angiotensin and melanocyte-stimulating hormone release-inhibiting factor. Biochem Biophys Res Commun 53(1), 244-250. URL = 4354931 (no abstract available)
Walter, R., K.U. Prasad, R. Deslauriers & I.C.P. Smith (1973). Conformational studies of oxytocin, lysine vasopressin, arginine vasopressin, and arginine vasotocin by carbon-13 nuclear magnetic resonance spectroscopy. Proc Natl Acad Sci U S a 70(7), 2086-2090. URL = 4516207 (no abstract available)
Butler, K.W., A.W. Hanson, I.C.P. Smith & H. Schneider (1973). The effects of protein on lipid organization in a model membrane system: a spin probe and x-ray study. Can J Biochem 51(7), 980-989. URL = 4353474 (no abstract available)
Lapper, R.D. & I.C.P. Smith (1973). A 13C and 1 H nuclear magnetic resonance study of the conformations of 2',3'-cyclic nucleotides. J Am Chem Soc 95(9), 2878-2880. URL = 4348541 (no abstract available)
Blackburn, B.J., R.D. Lapper & I.C.P. Smith (1973). A proton magnetic resonance study of the conformations of 3',5'-cyclic nucleotides. J Am Chem Soc 95(9), 2873-2878. URL = 4348540 (no abstract available)
Marsh, D. & I.C.P. Smith (1973). An interacting spin label study of the fluidizing and condensing effects of cholesterol on lecithin bilayers. Biochim Biophys Acta 298(2), 133-144. URL = 4352487 (no abstract available)
Butler, K.W., H. Schneider & I.C.P. Smith (1973). The effects of local anesthetics on lipid multilayers. A spin probe study. Arch Biochem Biophys 154(2), 548-554. URL = 4348008 (no abstract available)
Verma, S.P., H. Schneider & I.C.P. Smith (1973). Organizational changes in phospholipid multibilayers induced by uncouplers of oxidative phosphorylation: a spin label study. Arch Biochem Biophys 154 (1), 400-406. URL = 4120344 (no abstract available)
Verma, S.P., H. Schneider & I.C.P. Smith (1972). Spin probe studies of photo-induced structural changes in phospholipid multibilayers containing light-sensitive pigments. Febs Lett 25(1), 197-200. URL = 11946751 (no abstract available)
Lapper, R.D., S.J. Paterson & I.C.P. Smith (1972). A spin label study of the influence of cholesterol on egg lecithin multibilayers. Can J Biochem 50(9), 869-881. URL = 4342174 (no abstract available)
Lapper, R.D., H.H. Mantsch & I.C.P. Smith (1972). A carbon-13 and hydrogen-1 nuclear magnetic resonance study of the conformations of 3',5'- and 2',3'-cyclic nucleotides. A demonstration of the angular dependence of three-bond spin-spin couplings between carbon and phosphorus. J Am Chem Soc 94(17), 6243-6244. URL = 4341010 (no abstract available)
Deslauriers, R., R. Walter & I.C.P. Smith (1972). A carbon-13 nuclear magnetic resonance study of oxytocin and its oligopeptides. Biochem Biophys Res Commun 48(4), 854-859. URL = 4636649 (no abstract available)
Deslauriers, R. & I.C.P. Smith (1972). A proton magnetic resonance study of the influence of base ionization on the conformation of pseudouridine. Can J Biochem 50(7), 766-774. URL = 5050934 (no abstract available)
Paterson, S.J., K.W. Butler, P. Huang, J. Labelle, I.C.P. Smith & H. Schneider (1972). The effects of alcohols on lipid bilayers: a spin label study. Biochim Biophys Acta 266(3), 597-602. URL = 4339168 (no abstract available)
Malchy, B., H. Dugas, F. Ofosu & I.C.P. Smith (1972). A spin-label study of hemoglobin-haptoglobin complexes. Biochemistry 11(9), 1669-1672. URL = 4337556 (no abstract available)
Mantsch, H.H. & I.C.P. Smith (1972). Fourier-transformed 13 C NMR spectra of polyuridylic acid, uridine, and related nucleotides--the use of 31 POC 13 C couplings for conformational analysis. Biochem Biophys Res Commun 46(2), 808-815. URL = 5057909 (no abstract available)
Schleich, T., B.J. Blackburn, R.D. Lapper & I.C.P. Smith (1972). A nuclear magnetic resonance study of the influence of aqueous sodium perchlorate and temperature on the solution conformations of uracil nucleosides and nucleotides. Biochemistry 11(2), 137-145. URL = 4333200 (no abstract available)
Deslauriers, R., R.D. Lapper & I.C.P. Smith (1971). A proton magnetic resonance study of the molecular conformation of a modified nucleoside from transfer RNA. Dihydrouridine. Can J Biochem 49(12), 1279-1284. URL = 5139934 (no abstract available)
Neville, G.A., R. Deslauriers, B.J. Blackburn & I.C.P. Smith (1971). Conformational studies of amphetamine and medicinally important derivatives by nuclear magnetic resonance spectroscopy. J Med Chem 14(8), 717-721. URL = 4398854 (no abstract available)
Dugas, H., B.J. Blackburn, R.K. Robins, R. Deslauriers & I.C.P. Smith (1971). A nuclear magnetic resonance study of the conformation of beta-cyanuric acid riboside. Further evidence for the anti rotamer in pyrimidine nucleosides. J Am Chem Soc 93(14), 3468-3470. URL = 5560465 (no abstract available)
Hsia, J.C., H. Schneider & I.C.P. Smith (1971). A spin label study of the influence of cholesterol on phospholipid multibilayer structures. Can J Biochem 49(5), 514-522. URL = 4325030 (no abstract available)
Grey, A.A., I.C.P. Smith & F.E. Hruska (1971). A model for the molecular conformation of alpha-pseudouridine from nuclear magnetic resonance data. J Am Chem Soc 93(7), 1765-1769. URL = 5550249 (no abstract available)
Butler, K.W., I.C.P. Smith & H. Schneider (1970). Sterol structure and ordering effects in spin-labelled phospholipid multibilayer structures. Biochim Biophys Acta 219(2), 514-517. URL = 4322301 (no abstract available)
Butler, K.W., H. Dugas, I.C.P. Smith & H. Schneider (1970). Cation-induced organization changes in a lipid bilayer model membrane. Biochem Biophys Res Commun 40(4), 770-776. URL = 4322104 (no abstract available)
Deslauriers, R. & I.C.P. Smith (1970). Evidence from proton magnetic resonance data for the stacking of aromatic amino acids in lysine-vasopressin: comparison with oxytocin derivatives and related dipeptides. Biochem Biophys Res Commun 40(1), 179-185. URL = 5456954 (no abstract available)
Hruska, F.E., A.A. Grey & I.C.P. Smith (1970). A nuclear magnetic resonance study of the molecular conformation of beta-pseudouridine in aqueous solution. J Am Chem Soc 92(13), 4088-4094. URL = 5419047 (no abstract available)
Hsia, J.C., H. Schneider & I.C.P. Smith (1970). A spin label study of the effects of cholesterol in liposomes. Chem Phys Lipids 4(2), 238-242. URL = 4315770 (no abstract available)
Hsia, J.C., H. Schneider & I.C.P. Smith (1970). Spin label studies of oriented phospholipids: egg lecithin. Biochim Biophys Acta 202(2), 399-402. URL = 4315587 (no abstract available)
Hruska, F.E., A.A. Grey & I.C.P. Smith (1970). Conformational analysis of a minor nucleoside from nuclear magnetic resonance data. Pseudouridine. J Am Chem Soc 92(1), 214-215. URL = 5410110 (no abstract available)
Schneider, H. & I.C.P. Smith (1970). A study of the structural integrity of spin-labelled proteins in some fractions of human erythrocyte ghosts. Biochim Biophys Acta 219(1), 73-80. URL = 4319694 (no abstract available)
Smith, I.C.P., T. Yamane & R.G. Shulman (1969). Proton magnetic resonance studies at 220 MHz of alanine transfer RNA. Can J Biochem 47(4), 480-484. URL = 5769097 (no abstract available)
Smith, I.C.P., T. Yamane & R.G. Shulman (1968). Proton magnetic resonance of transfer RNA. Science 159(821), 1360-1361. URL = 5644263 (no abstract available)
Smith, I.C.P. (1968). A study of the conformational properties
of bovine pancreatic ribonuclease A by electron paramagnetic resonance. Biochemistry
7(2), 745-757.
URL = 4296191 (no abstract available)
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