Dr. Todd Duhamel
t duhamel

Associate Professor, Associate Dean (Research & Graduate Studies)
Director, Health, Leisure and Human Performance Research Institute (HLHPRI)
208 Active Living Centre
Winnipeg, MB, Canada
R3T 2N2
Phone: (204) 474-8922
Fax: (204) 474-7634
todd.duhamel@umanitoba.ca

Awards

•   2014 Dean’s Teaching Excellence Award, Faculty of Kinesiology and Recreation Management, University of Manitoba
•   2013 University of Manitoba Graduate Student Association Teaching Award
•   2012 University of Manitoba Merit Award for Combination of Teaching, Service, and/or Research, Scholarly Work& Other Creative Activities.

Research key words

Exercise physiology; Cardiovascular health; Cardiac rehabilitation; Physical activity; Diabetes; Biomedical science; Kinesiology; Exercise rehabilitation; Health promotion; Primary prevention; Integrated knowledge translation (iKT); Primary care; Health systems.

Research interests


Physical activity and health research is an area of fundamental importance. Therefore, my research program focuses onto two major research themes:


Basic exercise physiology: Although it is widely accepted that exercise training prevents and counteracts many of the disease processes that contribute to chronic disease, researchers still do not fully understand the biological mechanisms to explain how physical activity promotes health. With this in mind, my research program utilizes exercise physiology as a tool to identify novel therapeutic targets and signaling pathways that regulate cardiovascular and skeletal muscle health. In order to do so, my research program utilizes isolated cell models, animal models as well as human volunteers to conduct a physical activity-based physiology research program. Specifically, we have focused particular attention to study processes that are activated by physical activity to regulate calcium transport proteins and muscle metabolism in models of health and disease.

Clinical exercise physiology: Sufficient physical activity is a prerequisite for health. However, 85% of Canadian adults do not accumulate enough physical activity on a weekly basis to achieve health benefits. This statistic is alarming because the Public Health Agency of Canada estimates that physical inactivity contributes to the development of 25 different diseases, including diabetes, heart disease, stroke, cancer and mental disorders. With this in mind, my clinical research program seeks to better support the utilization of physical activity as a health intervention. To facilitate this clinical research program, I have created links with the Winnipeg Regional Health Authority, the regional cardiac rehabilitation programs at the Reh-Fit Center and the Wellness Institute at Seven Oaks Hospital, the Cardiovascular Health and Research in Manitoba (CHaRM) Investigator group at the St. Boniface Hospital and the Health, Leisure and Human Performance Research Institute at the University of Manitoba. As an example, my clinical research program has conducted prospective, observational trials examining the relationship between physical activity and mental health after cardiac surgery amongst a cohort of 450 patients. My research program has also conducted an integrated knowledge translation project examining the development and implementation of a model physical activity promotion program within primary health care, which we commonly refer to as the ENCOURAGE project. Notably, the ENCOURAGE project has helped participants to re-schedule their lives in a manner that enabled them be physically active for 100 minutes more per week than they were before.

Grant Funding

•    Canadian Institutes of Health Research
•    Technology Evaluation in the Elderly Network Core Research Grant Program, Networks of Centers of Excellence.
•    Heart and Stroke Foundation
•    St-Boniface Hospital Research Foundation

Trainee research placements

I enjoy providing students with opportunities to learn more about what it means to be a "researcher." In my own laboratory, I have been the primary mentor for two high school, 16 undergraduate, two B.Sc. Medicine, 11 Masters and two Doctoral students, as well as one visiting scientist since 2008.  I have also co-advised two Doctoral and one B.Sc. Med student. I do my best to provide an outstanding training environment for my student trainees by providing trainees with an opportunity to make meaningful contributions to the overall management of each project. I also enable students to interact with our research partners and stakeholders to inform best practice. Finally, I seek to tailor each research placement so the experiences gained fit within the student’s long-term career plan. Students with an interest to learn more about a research placement in my group can contact me by email.

Publications

(Underlining indicates student trainees who contributed to the publication).

Articles Published in Refereed Journals

  1. Serano F, Slaght J, Senechal M, Duhamel TA, and Bouchard DR. Identification and Prediction of the Walking Cadence Required to Reach Moderate Intensity in Older Adults. Journal of Aging and Physical Activity. Manuscript ID JAPA.2015-0262. Accepted. July 25, 2016. In press.
  2. Costa EC, Dantas TCB, de Farias Júnior LF, Frazão DT, Moreira SR, Ritti-Dias, RM, Prestes J, Tibana RA, and Duhamel TA. Inter- and intra-individual analysis of post-exercise hypotension following a single bout of high-intensity interval exercise and continuous exercise: A pilot study. International Journal of Sports Medicine. Manuscript ID: IJSM-03-2016-5575-tt.R2. Accepted. In press.
  3. Norman ME, Petherick L, Garcia E, Glazebrook C, Giesbrecht G and Duhamel TA. Examining the More-Than-Built-Environments of a Northern Manitoban Community: Reconceptualizing Rural Indigenous Mobilities. Journal of Rural Studies 42. 166-178. 2015. DOI information: 10.1016/j.jrurstud.2015.09.008.
  4. McGavock J, Hay J, Wittmeier K, MacIntosh A, Duhamel TA, Sellers E, Dean H, Ready E, Berard L, Kriellaars D, Gardiner P, Wicklow B. Physical Activity Intensity and Diabetes Risk in Overweight Youth: The POWER Trial. Accepted. International Journal of Obesity. Paper #: 2014IJO02247. In press.
  5. Wicklow B, Wittmeier K, Jong GW, McGavock J, Robert M, Duhamel TA, and Dolinsky VW. Safety and Efficacy of Resveratrol for the Treatment of Non-Alcoholic Fatty Liver Disease and Associated Insulin Resistance in Overweight and Obese Adolescents: Rationale and Protocol. Accepted. Biochemistry and Cell Biology. Manuscript ID: bcb-2014-0136. In press. Biochem Cell Biol. 2015 Jul 10:1-9.
  6. Fajardo VA, Bombardier E, Irvine T, Metherel AH, Duhamel TA, Holloway GP, Rush JWE, Green HJ, Stark, KD and Tupling AR. Dietary docosahexaenoic acid supplementation reduces SERCA Ca2+ transport efficiency in rat skeletal muscle. Chem Phys Lipids. 187:56-61. 2015. doi: 10.1016/j.chemphyslip.2015.03.001. PMID: 25772907.
  7. Stammers AN, Susser SE, Hamm NC, Hlynsky M, Kimber DE, Kehler, DS and Duhamel TA. The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA). CJPP. 19:1-12. 2015. PMID: 25730320.
  8. Stammers AN, Kehler DS, Afilalo J, Avery LJ, Bagshaw S, Legare JF, Logsetty S, Metge C, Nguyen T, Rockwood K, Sareen J, Sawatzky J, Tangri N, Giacomantonio N, Hassan A, Duhamel TA and Arora RC. Protocol for the PREHAB Study - Pre-operative Rehabilitation for reduction of Hospitalization After coronary Bypass and valvular surgery: A Randomized Controlled Trial. British Medical Journal Open. 9;5(3):e007250. 2015. doi: 10.1136/bmjopen-2014-007250.
  9. Sénéchal M, Rempel M, Duhamel TA, MacIntosh AC, Hay J, Wicklow B, Wittmeier K, McGavock J. Fitness is a Determinant of the Metabolic Response to Endurance Training in Adolescents at Risk of Type 2 Diabetes Mellitus. Obesity. 23(4):823-32. 2015. doi: 10.1002/oby.21032.
  10. Kehler DS, Stammers AN, Susser SE, Hamm NC, Kimber DE, Hlynsky MW and Duhamel TA. Cardiovascular Complications of Type 2 Diabetes in Youth. Biochemistry and Cell Biology. Dec 7:1-15. 2014.Grace SL, Parsons TL, Duhamel TA, Somanader DS, Suskin N. The Quality of Cardiac Rehabilitation in Canada: A Report of the Canadian Cardiac Rehab Registry. Accepted on June 25, 2014 to the Canadian Journal of Cardiology. Manuscript # CJC-S-14-00641. In press.
  11. Morissette MP, Susser SE, Stammers AN, O’Hara KA, Gardiner P, Sheppard P, Moffatt TL and Duhamel TA. Differential regulation of the fiber type specific gene expression of the sarcoplasmic reticulum calcium-ATPase (SERCA) isoforms induced by exercise training. J Appl Physiol. 2014 May 29. pii: jap.00092.2014. In press. [Epub ahead of print] PMID: 24876362.
  12. Sawatzky J†, Kehler DS†, Ready R, Arora RC‡, and Duhamel TA‡. Pre-habilitation program for elective coronary artery bypass graft surgery patients. Journal of Clinical Rehabilitation 28(7):648-657. 2014. PMID: 24459173. Clinical Trial Registry #: NCT01914094. † indicates an equal contribution to the project that warrants co-first authorship. ‡ indicates an equal contribution to the project that warrants co-senior authorship.
  13. Horne D†, Kehler DS†, Kaoukis G, Hiebert B, Garcia E, Chapman S, Duhamel TA‡, Arora RC‡. Impact of Physical Activity on Depression after Cardiac Surgery (IPAD-CS). Accepted for publication. Canadian Journal of Cardiology on August 18, 2013. † indicates an equal contribution to the project that warrants co-first authorship. ‡ indicates an equal contribution to the project that warrants co-senior authorship.
  14. Epp RA, Susser SE, Morissette MP, Kehler DS, Jassal DS and Duhamel TA. Exercise training prevents the development of cardiac dysfunction in the high fat diet-fed, low-dose streptozotocin diabetic rat. Canadian Journal of Physiology and Pharmacology. 91(1):80-9. 2013. Funded by the Heart and Stroke Foundation.
  15. Horne D†, Kehler DS†, Kaoukis G, Hiebert B, Garcia E, Duhamel TA‡, Arora RC‡. Depression before and after cardiac surgery: do all patients respond the same? Journal of Thoracic and Cardiovascular Surgery. 145(5):1400-6. 2013. † indicates an equal contribution to the project that warrants co-first authorship. ‡ indicates an equal contribution to the project that warrants co-senior authorship. Funded by the Manitoba Health Research Council.
  16. Hnatiuk JA, Duhamel TA, Katz A, Ready AE. Physical Activity Supports Provided by Health Care Providers to Patients with Type 2 Diabetes. Can J  Diabetes. 36.119-127. 2012.
  17. Green HJ, Duhamel TA, Smith IC, Rich SM, Thomas MM, Ouyang J, Yau JE. Muscle Fatigue and Excitation-Contraction Coupling Responses Following a Session of Prolonged Cycling. Acta Physiol (Oxf). 203(4):441-55. doi: 10.1111/j.1748-1716.2011.02335.x. 2011. Funded by NSERC.
  18. Green HJ, Duhamel TA, Smith IC, Rich SM, Thomas MM, Ouyang J, Yau JE. Muscle metabolic, enzymatic and transporter responses to a session of prolonged cycling. Eur J Appl Physiol. 111(5):827-37. 2011. Funded by NSERC.
  19. Bohm CJ, Ho J and Duhamel TA. Regular physical activity and exercise therapy in end-stage renal disease: how should we move forward? J Nephrol. 23(3):235-43. 2010.
  20. Adameova A, Xu YJ, Duhamel TA, Tappia PS, Shan L, Dhalla NS. Anti-atherosclerotic Molecules Targeting Oxidative Stress and Inflammation. Curr Pharm Design 15: 3094-3107. 2009. Funded by the Canadian Institute for Health Research.
  21. Green HJ, Bombardier E, Duhamel TA, Stewart RD, Tupling AR, and Ouyang J. Metabolic, enzymatic and transporter responses in human muscle during consecutive days of exercise and recovery. Am J Physiol Regul Integr Comp Physiol. 295(4):R1238-50.2008. Funded by NSERC.
  22. Dhalla NS, Sani-Chohan HK, and Duhamel TA. Strategies for the regulation of intracellular calcium in ischemic heart disease. Future Cardiology. 4(4), 339-345. 2008. Funded by the Canadian Institute for Health Research.
  23. Green HJ, Burnett ME, Duhamel TA, D'Arsigny CL, O'Donnell DE, Webb KA, Ouyang J. Abnormal Sarcoplasmic Reticulum Calcium-Sequestering Properties in Skeletal Muscle in Chronic Obstructive Pulmonary Disease. Am J Physiol Cell Physiol. 295(2):C350-7. 2008. Funded by NSERC.
  24. Green HJ, Duhamel TA, Stewart RD, Tupling AR, and Ouyang J. Dissociation between changes in muscle Na+-K+-ATPase isoform abundance and activity with consecutive days of exercise and recovery. Am J Physiol: Endo Metab. 294(4):E761-7. 2008. Funded by NSERC.
  25. Green HJ, Bombardier E, Duhamel TA, Holloway GP, Moule J, Ranney DW, Tupling AR and Ouyang J. Acute responses in muscle mitochondrial and cytosolic enzyme activities during heavy intermittent exercise. J Appl Physiol. 104(4):931-7. 2008. Funded by NSERC.
  26. Stewart RD, Duhamel TA, Tupling AR and Green HJ. Effects of consecutive days of exercise and recovery on muscle mechanical function. Med Sci Sports Exerc. 40(2):316-25. 2008. Funded by NSERC.
  27. Green HJ, Duhamel TA, Holloway GP, Moule J, Ranney DW, Tupling AR and Ouyang J. Rapid upregulation of GLUT4 and MCT4 expression during sixteen hours of heavy intermittent cycle exercise. Am J Physiol Regul, Integ Comp Physiol. 294(2):R594-600. 2008. Funded by NSERC.

Invited Commentaries Published in Refereed Journals

  • Czubryt M, Wigle J, Duhamel T, Singal P. Preface to: Scientific Basis for Heart Health and Care (Winnipeg Heart International Conference). Can J Physiol Pharmacol. 2012 Aug;90(8):v. Epub 2012.
  • Duhamel TA. Viewpoint: Fatigue mechanisms determining exercise performance: integrative physiology is systems physiology. J Appl Physiol. 104(5):1544. 2008.


Published Reports

  • Duhamel TA, McDonald G, Garcia E, Chapman C, Kehler DS, Petheric L, Norman TM, Buchanan P, Glazebrook C, Gysel A, Brown K, Giesbrecht G, Dunn N. AFTER THE SCHOOL BELL RINGS: A Manitoba After School Recreation Project. 1-258. 2013. http://www.afterschoolmanitoba.ca/assets/after%20the%20bell_july24_final.pdf Accessed on September 23, 2013. Winnipeg, MB, Canada.
  • Buchanan P, Norman M, Petherick L, Duhamel TA. Getting Girls Active: Examining the Physically Active Recreation Experiences of Ethno-Racially Diverse Girls. Boys and Girls Club Canada - City of Winnipeg. Funding Organization: Public Health Agency of Canada (PHAC 6269-07-2010/1092046. Manuals. Date Submitted June 30, 2012.


Published Book Chapters              

  • Hamm NC, Stammers AN, Susser SE, Hlynsky M, Kimber DE, Kehler DS, and Duhamel TA. Regulation of Cardiac Sarco(endo)plasmic reticulum calcium-ATPases (SERCA2a) in Response to Exercise. In:  "Regulation of Ca2+-ATPases,V-ATPases and F-ATPases" Ed. Sajal Chakraborti & Naranjan S Dhalla. Published by Springer. November 2015.
  • Kehler DS, Dhalla NS and Duhamel TA. Biochemical Mechanisms of Exercise-Induced Angiogenesis. In: Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 181-206). Ed. By JL Mehta and NS Dhalla, Springer Science+Business Media, LLC, New York. 2013.
  • Duhamel TA and Dhalla NS. Molecular Mechanisms of Renin-Angiotensin-Aldosterone Blockade in Congestive Heart Failure.  In: Recent Advances in Cardiovascular Sciences, Ed. by S.S. Agrawal, DIPfSAR, Govt. of NCT Delhi, New Delhi, 1-41. 2008.


Knowledge translation publications

  • Duhamel T. (2013). 100 Steps a Minute. Reh-fit Center. http://www.reh-fit.com/fitness-basics/100-steps-a-minute/ Accessed on June 18, 2013. Winnipeg, MB. Canada.
  • Kent D,  Kehler DS, and Duhamel T. (2013). A prescription for exercise? Winnipeg Regional Health Authority. Inspire:News and information for staff working for the Winnipeg Regional Health Authority. http://www.wrha.mb.ca/extranet/inspire/2013/130612-a-prescription-for-exercise.php Accessed on June 25, 2013. Winnipeg, MB. Canada.
  • Kent D,  Kehler DS, Prowse S, and Duhamel T. (2013). Are you physically active enough? Winnipeg Regional Health Authority. WAVE (Winnipeg's health and wellness magazine) Published on August 27, 2013. Winnipeg, MB. Canada. http://www.wrha.mb.ca/wave/2013/09/files/WaveFull-1309.pdf Accessed on September 23, 2013. Winnipeg, MB. Canada.


Published Theses
M.Sc. Students

  • Garcia, E. (2013) The Pedometer Project: Using an Individualized Cadence-Based Exercise Prescription (CBEP) to Increase the Amount of Moderate-Vigorous Physical Activity Accumulated by a Cohort of Previously Inactive Adults. November 1, 2013.
  • Morissette M. (2013) Examining the role of the adenosine monophosphate-activated protein kinase a2 (AMPKa2) subunit on sarcoplasmic reticulum calcium-ATPase (SERCA) expression and function in sedentary and exercise-trained mice. University of Manitoba. Winnipeg, MB, Canada. April 2013.
  •  Kehler SD (2012) Pre-habilitation Program for Elective Coronary Artery Bypass Graft Surgery Patients: A Pilot Project. University of Manitoba. Winnipeg, MB, Canada. April 2013.
  • B.Sc. Med Thesis
  • Wanigasekara, N. (2012) Examining the effects of a novel model of cardiac rehabilitation in reducing wait times and increasing adherence to behavior changes promoted by the program. University of Manitoba. Winnipeg, MB, Canada. August 2012.
  •  Epp R. (2013). The ENCOURAGE project: Fee for service interviews. University of Manitoba. Winnipeg, MB, Canada. August 2013.

 

Published Media Reports

          -  Title: Physical inactivity after cardiac surgery linked with substantially higher risk of depression. Patients undergoing cardiac surgery should be assessed for depression and physical activity, say researchers in the Canadian Journal of Cardiology.
          -  http://www.elsevier.com/about/press-releases/research-and-journals/physical-inactivity-after-cardiac-surgery-linked-with-substantially-higher-risk-of-depression#sthash.tBNbKw2K.dpuf
          -    December 18, 2013

Courses

Graduate level courses

  • Current Research in Physical Activity, Health and Leisure: Physical Aspects (PERS 7004)
  • Research in Kinesiology and Recreation Studies (PERS 7080
  1.  Cardiac Science and Exercise Physiology
  2. Cardiac Rehabiliation Research
  3. Exercise Biology
  • Advanced Training in Basic and Clinical Research Topics in Medicine (Department of Physiology, Faculty of Medicine University of Manitoba & St Boniface Hospital)

Undergraduate level courses

  • Advanced Exercise Physiology (KIN 4470)
  • Advanced Pathology and Sport Medicine (KIN 4160)
  • Supervised Fieldwork placements (PERS 4630)
  • Undergraduate Directed Studies (PERS 4600) 

 

Current Graduate Students
Scott Kehler
Marc Morissette
Eric Garcia
David Kent
Krista Stewart