Position: Professor
Office:
University of Manitoba
Department of Human Nutritional Sciences
R 2035 St. Boniface Research Centre
351 Tache Avenue
Winnipeg, MB R2H 2A6 Canada
Laboratory:
R 2035 St. Boniface Research Centre
Phone No.: (204) 258-1361
Fax No.: (204) 237-4018
E-mail: ctaylor@cc.umanitoba.ca
Dr. Taylor investigates the effects of various dietary components on obesity, insulin resistance and vascular health using animal models and human studies. Specific dietary components she is researching include omega-3 fatty acids, conjugated linoleic acid, and plant-based bioactives in crops such as buckwheat and pulses. She is also researching the effects of zinc on antioxidant and immune defense.
Education:
Ph.D. (Department of Nutritional Sciences, University of Guelph), 1990
B.H. Ecol. (Department of Foods and Nutrition, University of Manitoba), 1984
Research Interests:
Dietary modulation of insulin resistance and obesity:
Effects of dietary fatty acids [omega-3 fatty acids, conjugated linoleic acid (CLA)] and bioactive compounds found in plants/agricultural crops (e.g. buckwheat, pulses) on glycemic control, insulin resistance, adipokines and adipose function.
Nutrition, antioxidant and immune defense:
Effects of dietary zinc on T-lymphocyte development and zinc-finger proteins involved in cell signaling.
Protective effects of zinc supplementation during inflammation and heavy metal toxicity.
Recent Publications:
DeClercq, V., Taylor, C.G., and Zahradka, P. (2011) Isomer-specific effects of conjugated linoleic acid (CLA) on blood pressure, adipocyte size and function. Br. J. Nutr. (in press).
DeClercq, V., Taylor, C.G., Wigle, J., Wright, B., Tworek, L., and Zahradka, P. (2011) Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity. J. Nutr. Biochem. Epub 16 Jun.
Louis, X.L., Thandapilly, S.J., Mohankumar, S.K., Yu, L., Taylor, C.G., Zahradka, P., and Netticadan T. (2011) Treatment with low dose resveratrol reverses cardiac impairment in obese prone but not in obese resistant rats. J. Nutr. Biochem. (in press).
Suh, M., Merrells, K.J., Dick, A., and Taylor, C.G. (2011) Testes of obese rats are highly responsive to n-3 long chain fatty acids. Br. J. Nutr. Epub 13 Apr.
Enns, J.E., Taylor, C.G., and Zahradka, P. (2011) Variations in adipokine genes AdipoQ, Lep, and LepR are associated with risk for obesity-related metabolic disease: the modulatory role of gene-nutrient interactions. J. Obesity 2011:168659.
Thandapilly, S.J., Louis, X.L., Yang, T., Stringer, D.M., Yu, L., Zhang, S., Wigle, J., Kardami, E., Zahradka, P., Taylor, C.G., Anderson, H.D., and Netticadan, T. (2011) Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway. Eur. J. Pharmacol. 668:217-24.
Zhao, J., Gillam, M.E., Taylor, C.G., and Weiler, H.A. (2010) Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in alpha-linolenic acid but devoid of DHA. J. Nutr. Biochem. 22(9):835-42.
Prescod, A.L., Halliday, W.C., and Taylor, C.G. (2011) Protein deficiency, but not zinc deficiency, reduces recovery of type 1 and type 2 muscle fibre diameters in the gastrocnemius muscle of growing rats. Br. J. Nutr. 106:675-82.
Stringer, D.M., Zahradka, P., DeClercq, V., Ryz, N.R., Diakiw, R., Burr, L.L., Xie, X., and Taylor, C.G. (2010) Modulation of lipid droplet size and lipid droplet proteins by trans-10, cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1801:1375-85.
DeClercq, V.C., Taylor, C.G., and Zahradka, P. (2010) Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa/fa Zucker rats. Lipids 45:1025-33.
Taylor, C.G., Noto, A.D., Stringer, D.M., Froese, S., and Malcolmson, L. (2010) Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. J. Am. Coll. Nutr. 29:72-80.
Wojciechowski, P., Juric, D., Louis, X.L., Thandapilly, S.J., Yu, L., Taylor, C.G., and Netticadan, T. (2010) Resveratrol arrests and regresses the development of pressure overload - but not volume overload-induced cardiac hypertrophy in rats. J. Nutr. 140:962-968.
Curran, J., Stringer, D., Wright, B., Taylor, C.G., Przybylski, R., and Zahradka, P. (2010) Biological response of hepatomas to an extract of Fagopyrum esculentum M. (buckwheat) is not mediated by inositols or rutin. J. Agr. Food Chem. 58:3197-3204.
Massip, L., Garand, C., Paquet, E.R., Cogger, V.C., O'Reilly, J.N., Tworek, L., Hatherell, A., Taylor, C.G., Thorin, E., Zahradka, P., Le Couteur, D.G., and Lebel, M. 2010. Vitamin C restores healthy aging in a mouse model for Werner syndrome. FASEB J. 24:158-72.
Gillam, M., Noto, A., Zahradka, P., and Taylor, C.G. 2009. Improved n-3 fatty acid status does not modulate insulin resistance in fa/fa Zucker rats. Prostaglandins Leukot Essent Fatty Acids. 81:331-9.
Merrells, K.J., Blewett, H., Jamieson, J.A., Taylor, C.G., and Suh, M. 2009 Relationship between abnormal sperm morphology induced by dietary zinc deficiency and lipid composition in testis of growing rats. Br. J. Nutr. 102: 226-32.
Ryz, N.R., Weiler, H.A., and Taylor, C.G. 2009 Zinc deficiency reduces bone mineral density in the spine of young adult rats: A pilot study. Annal. Nutr. Metab. 54: 218-226.
Szczurek, E.I., Bjornsson, C.S., Noto, A.D. and Taylor, C.G. 2009 Renal metallothionein responds rapidly and site-specifically to zinc repletion in growing rats. J. Trace Elem. Med. 23: 176-182.
Al-Gindan, Y., Shawarby, M., Noto, A., and Taylor, C.G. 2009 Intestinal inflammation in rats induces metallothionein in colonic submucosa. J. Clin. Biochem. Nutr. 44: 131-141.
Stringer, D.M., Sellers, E.A.C., Burr, L.L., and Taylor, C.G. 2009 Altered plasma adipokines and markers of oxidative stress suggest increased risk of cardiovascular disease in First Nation youth with obesity or type 2 diabetes mellitus. Pediatric Diabetes 10: 269-77.
Ryz, N., Meddings, J.B., and Taylor, C.G. 2009 Long-chain inulin increases dendritic cells in the Peyer’s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status. Br. J. Nutr. 101: 1653-63.
Drury, B., Warford-Woolgar, L.J., Herchak, D.J., Bankovic-Calic, N., Crow, G., Taylor, C.G., Zahradka, P., Ogborn, M.R., and Aukema, H.M. 2009 Dietary trans10, cis12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa Zucker rats. J. Nutr. 139: 285-290.
Ruth, M.R., Taylor, C.G., Zahradka, P., and Field, C.J. 2008 Abnormal immune responses in fa/fa Zucker rats and effects of feeding conjugated linoleic acid. Obesity 16: 1770-1779.
Hosea Blewett, H.J., Rector, E.S., and Taylor, C.G. 2008 Altered ex vivo cytokine production in zinc-deficient, pair-fed, and marginally zinc-deficient growing rats is independent of serum corticosterone concentrations. Br. J. Nutr. 100: 820-8.
Jamieson, J.A., Ryz, N.R., Taylor, C.G., and Weiler, H.A. 2008 Dietary long-chain inulin reduces abdominal fat but has no effect on bone density in growing female rats. Br. J. Nutr. 100: 451-9.
Hwang, S.-Y., Taylor, C.G., Zahradka, P., Bankovic-Calic, N., Ogborn, M.R., and Aukema, H.M. 2008 Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa Zucker rats. J. Nutr. Biochem. 19:255-262.
Jamieson, J.A., Stringer, D.M., Zahradka, P., and Taylor, C.G. 2008 Dietary zinc attenuates renal lead deposition but metallothionein is not directly involved. Biometals 21: 29-40.
Hosea, H.J., Rector, E.S., and Taylor, C.G. 2007 Dietary zinc deficiency lowers the proportions of splenic CD90+ (Thy-1+) B-cells and late thymic emigrant T-cells in growing rats. Br. J. Nutr. 98: 1108-11.
Noto, A., Zahradka, P., Yurkova, N., Xie, X., Truong, H., Nitschmann, E., Ogborn, M., and Taylor, C. G. 2007 Conjugated linoleic acid (CLA) alters adipokine status and improves insulin resistance independently of adipose mass in obese insulin-resistant rats. Metabolism 56: 1601-11.
Noto, A., Zahradka, P., Ryz, N.R., Yurkova, N., Xie, X., and Taylor, C.G. 2007 Conjugated linoleic acid (CLA) preserves pancreatic function and reduces inflammatory markers in obese insulin-resistant rats. Metabolism 56:142-151.
Jamieson, J.A., Shuhyta, J.N., and Taylor, C.G. 2007 Lead does not affect transcription of intestinal zinc-binding proteins in growing rats. Exp. Biol. Med. 232: 744-53.
Burr L.L., Taylor, C.G., and Weiler, H.A. 2006 Conjugated linoleic acid isomers, cis-9, trans-11 and trans-10, cis-12, fed in combination have a greater effect on bone mass than single isomers in fa/fa and lean Zucker rats. Exp. Biol. Med. 231: 1602-1609.
Jamieson, J., Taylor, C.G., and Weiler, H.A. 2006 Marginal zinc deficiency exacerbates bone lead deposition and high dietary zinc attenuates lead deposition at the expense of bone density in growing rats. Toxicol. Sci. 92: 286-294.
Noto, A., Zahradka, P., Yurkova, N., Xie, X., Nitschmann, E., Ogborn, M., and Taylor, C.G. 2006 Conjugated linoleic acid (CLA) reduces hepatic steatosis, improves liver function and favorably modifies lipid metabolism in obese insulin resistant rats. Lipids 41: 179-188.
Zahradka, P., Wright, B., Fuerst, M., Yurkova, N., Molnar, K., and Taylor, C.G. 2006 Peroxisome proliferator-activated receptor (PPAR) {alpha} and {gamma} ligands differentially affect smooth muscle cell proliferation and migration. J. Pharmacol. Exp. Ther. 317: 651-9.