Mohammed Moghadasian

moghadasian

Position: Professor

Office:
St. Boniface Research Centre
St. Boniface Hospital
Winnipeg, MB R2H 2A6Canada

Phone No.: (204) 235-3934

Fax No.: (204) 231-1151

E-mail: mmoghadasian@sbrc.ca


Dr. Moghadasian’s research interest includes investigation of the roles of dietary lipids in lipoprotein metabolism and the pathogenesis and/or prevention of atherogenesis using well established animal models. Dr. Moghadasian’s research goal is to provide scientific evidence for development of new functional foods and neutraceuticals for prevention of cardiovascular diseases

Education:

PhD 1998 University of British Columbia, Canada
MSc 1994 University of British Comumbia, Canada
DVM 1986 Shiraz University, Iran

Teaching:

  • Functional Foods and Nutraceuticals
  • Maternal and Child Nutrition
  • Lipid Nutrition and Metabolism
  • Nutrition Through the Life Cycle

Areas of Specialization:

Lipoprotein metabolism and atherosclerosis

Research Interests:

  • Diet
  • Lipoprotein metabolism
  • Coronary artery disease
  • Diet-Drug Interaction

Selected Publications:

Zhao R, Moghadasian MH, Shen GX. Involvement of NADPH oxidase in up-regulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts induced by oxidized LDL and in apolipoprotein E-deficient mice. Free Radic Res. 2011;45(9):1013-23.

Othman RA, Moghadasian MH. Beyond cholesterol-lowering effects of plant sterols: Clinical and experimental evidence of anti-inflammatory properties. Nutr Rev. 2011;69(7):371-82.

Othman RA, Moghadasian MH, Jones PJH. Cholesterol-lowering effects of oat β-glucan. Nutr Rev. 2011;69(6):299-309.

Bonomini F, Rodella LF, Moghadasian M, Lonati C, Coleman R, Rezzani R. Role of apolipoprotein e in renal damage protection. Histochem Cell Biol. 2011;135(6):571-9.

Ahmadie R, Santiago J-, Walker J, Fang T, Le K, Zhao Z, et al. A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload. J Nutr. 2010;140(8):1438-44.

Zhao Z, Moghadasian MH. Bioavailability of hydroxycinnamates: A brief review of in vivo and in vitro studies. Phytochemistry Reviews. 2010;9(1):133-45.

Xu Z, Azordegan N, Zhao Z, Le K, Othman RA, Moghadasian MH. Pro-atherogenic effects of probucol in apo E-KO mice may be mediated through alterations in immune system: Parallel alterations in gene expression in the aorta and liver. Atherosclerosis. 2009;206(2):427-33.

Riediger ND, Azordegan N, Harris-Janz S, Ma DWL, Suh M, Moghadasian MH. 'Designer oils' low in n-6:N-3 fatty acid ratio beneficially modifies cardiovascular risks in mice. Eur J Nutr. 2009;48(5):307-14.

Zhao Z, Xu Z, Le K, Azordegan N, Riediger ND, Moghadasian MH. Lack of evidence for antiatherogenic effects of wheat bran or corn bran in apolipoprotein E-knockout mice. J Agric Food Chem. 2009;57(14):6455-60.

Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc. 2009;109(4):668-79.

Abdullah MM, Riediger NN, Chen Q, Zhao Z, Azordegan N, Xu Z, et al. Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in sprague-dawley rats. Mol Cell Biochem. 2009;327(1-2):247-56.

Azordegan N, Yazdankhah A, Moghadasian MH. A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. Arch Gynecol Obstet. 2009;279(2):183-7.

Jassal DS, Othman RA, Ahmadie R, Fang T, Zieroth S, Fischer G, et al. The role of tissue doppler imaging in the noninvasive detection of chronic rejection after heterotopic cardiac transplantation in rats. Echocardiography. 2009;26(1):37-43.

Ree M, Riediger N, Moghadasian MH. Factors affecting food selection in canadian population. Eur J Clin Nutr. 2008;62(11):1255-62.

Barceló-Coblijn G, Murphy EJ, Othman R, Moghadasian MH, Kashour T, Friel JK. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: A multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am J Clin Nutr. 2008;88(3):801-9.

Zhao Z, Moghadasian MH. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review. Food Chem. 2008;109(4):691-702.

Xu Z, Le K, Moghadasian MH. Long-term phytosterol treatment alters gene expression in the liver of apo E-deficient mice. J Nutr Biochem. 2008;19(8):545-54.

Moghadasian MH. Advances in dietary enrichment with N-3 fatty acids. Crit Rev Food Sci Nutr. 2008;48(5):402-10.

Riediger ND, Othman R, Fitz E, Pierce GN, Suh M, Moghadasian MH. Low n-6:N-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice. Eur J Nutr. 2008;47(3):153-60.

Riediger ND, Moghadasian MH. Patterns of fruit and vegetable consumption and the influence of sex, age and socio-demographic factors among Canadian elderly. J Am Coll Nutr. 2008;27(2):306-13.

Othman RA, Suh M, Fischer G, Azordegan N, Riediger N, Le K, et al. A comparison of the effects of fish oil and flaxseed oil on cardiac allograft chronic rejection in rats. American Journal of Physiology - Heart and Circulatory Physiology. 2008;294(3):H1452-8.

Bahadori B, Uitz E, Tonninger-Bahadori K, Moghadasian MH. Successful treatment of a morbidly obese and growth-retarded adolescent with williams-beuren syndrome by combining the medication of growth hormone and sibutramine. Singapore Med J. 2008;49(1):e15-6.

Dupasquier CMC, Dibrov E, Kneesh AL, Cheung PKM, Lee KGY, Alexander HK, et al. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. American Journal of Physiology - Heart and Circulatory Physiology. 2007;293(4):H2394-402.

Riediger ND, Shooshtari S, Moghadasian MH. The influence of sociodemographic factors on patterns of fruit and vegetable consumption in Canadian adolescents. J Am Diet Assoc. 2007;107(9):1511-8.

Abdullah MM, Xu Z, Pierce GN, Moghadasian MH. The effects of simultaneous administration of dietary conjugated linoleic acid and telmisartan on cardiovascular risks in rats. Lipids. 2007;42(9):855-64.

Xu Z, Fitz E, Riediger N, Moghadasian MH. Dietary octacosanol reduces plasma triacylglycerol levels but not atherogenesis in apolipoprotein E-knockout mice. Nutr Res. 2007;27(4):212-7.

Xu Z, Riediger N, Innis S, Moghadasian MH. Fish oil significantly alters fatty acid profiles in various lipid fractions but not atherogenesis in apo E-KO mice. Eur J Nutr. 2007;46(2):103-10.