Academic Staff
Geoff Tranmer, PhD
Assistant Professor

Research Group Website

Dr. Geoffrey Tranmer, a native of Lindsay Ontario Canada, began his endeavors into scholarly research as an undergraduate at Brock University working in the lab of Professor Fred Capretta as a fourth-year thesis student.

Upon completion of his honours degree in Chemistry, he enrolled as a graduate student at the University of Guelph, studying the “1,3-Dipolar Cycloadditions of Nitrones Tethered to Norbornadiene: Scope and Applications”, under the supervision of Professor William Tam.

Dr. Tranmer initiated his post-doctoral studies at Princeton University working with professor Martin Semmelhack, studying the application of molecular design towards bacterial quorum sensing.

Following this tenure, and an NSERC post-doctoral fellowship, he continued his studies in the group of Professor Steven V. Ley at the University of Cambridge researching the development and application of new technologies in organic synthesis, with particular focus on flow chemistry and microwave-assisted organic synthesis.

Dr. Tranmer's first industrial role was as a senior research chemist at Merck Frosst in Montreal as a member of the technology enabled synthesis group, integrating the application of automated synthesis and purification into medicinal chemistry programs. Following subsequent employment at McMaster University as the synthesis and NMR lab manager in the centre for microbial chemical biology, and research at the centre for probe development and commercialization, he accepted the appointment of assistant professor in the College of Pharmacy.

Dr. Tranmer has co-authored 16 papers and three reviews in peer-reviewed journals, and has been named as co-inventor on six published patent applications and will focus his research and teaching in the area of medicinal chemistry. “Geoff Tranmer – Taking the “ick” out of Organ-ic Synthesis since 1998”

Program overview

Synthetic organic chemistry has already had a significant impact on the fields of medicinal chemistry and chemical biology, with major advancements being applied towards developing new pharmaceutical therapies and for the study and manipulation of biological systems.

With this in mind, the future of synthetic organic chemistry will involve the development and application of innovative technologies in the field of organic synthesis, new strategies for targeted cancer therapies and the development of novel techniques that can be used to probe and elucidate the intricate facets of chemical biology.

Dr. Tranmer's research interests are largely focused on these main themes, and have an end goal of improving the process of drug discovery and facilitating innovation in chemical biology.

Specifically, he is interested in developing novel flow chemistry techniques that will aim at enhancing current synthetic organic methodologies, and focus on lead generation and optimization in drug discovery, while simultaneously focusing on the development of novel targeted cancer therapies and bioconjugation modalities.

As an assistant professor, he leverages both his academic and industrial experience to bridge the gap between chemistry and biology, academics and industry, to champion research programs that are directed at developing and applying innovative synthetic organic technologies and methods to the fields of medicinal chemistry and chemical biology.

Research areas/interests

Medicinal chemistry: drug discovery, chemical biology, organic synthesis

Flow chemistry: development and application of new synthetic technologies in medicinal chemistry and chemical biology programs, development of targeted cancer therapies, development of novel bioconjugation methodologies for use in chemical biology

Education/training background

Senior Research Chemist, Merck Frosst Canada Ltd. NSERC

Post-Doctoral Fellow, University of Cambridge, Supervisor: Prof. Steven V. Ley PhD, University of Guelph,

Organic Chemistry, Supervisor: Prof. William Tam BSc (Hons), Brock University, Chemistry

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