Academic Staff
Yuewen Gong, BM, PhD
Professor

Dr. Yuewen Gong, B.M. (Beijing), M.Sc. (Beijing), PhD (Manitoba) is a professor at the College of Pharmacy with a cross-appointment in the Department of Internal Medicine of the Max Rady College of Medicine, Rady Faculty of Health Sciences.

Dr. Gong received the Bachelor of Medicine in Traditional Chinese Medicine from the Beijing college of Traditional Chinese Medicine in 1983, the M.Sc. in pathophysiology from the Peking Union Medical College in 1986 and the PhD in Molecular Endocrinology in the Department of Physiology at the University of Manitoba in 1993. After graduation he completed postdoctoral trainings at the Mayo Clinic and the University of Manitoba.

Over the past years, Dr. Gong has been an assistant professor, associate professor and professor at the University of Manitoba.

The focus of Dr. Gong’s research program is to understand the mechanism of liver fibrosis and cancer, and develop a treatment for these conditions.

Professor Gong has published more than 100 peer-reviewed papers in various journals including Gastroenterology, Hepatology, Cancer Research, Endocrinology, Journal of Cellular Physiology, American Journal of Physiology, Journal of Pharmacy and Pharmaceutical Sciences. He has also published more than more than 90 conference abstracts. His work has been cited more than 3138 times by other colleagues and h-index is 33 according to Google Scholar. Dr. Gong has given more than 60 invited seminars/keynote presentations to a variety of academic institutes, government agencies and high-profile international conferences.

The research in Dr. Gong’s laboratory has been supported by the Canadian Institute of Health Research, the Natural Science & Engineering Research Council of Canada, Health Canada, the Manitoba Medical Service Foundation, the Health Sciences Foundation, Dr. Paul H.T. Thorlakson Foundation Fund, the University Research Grant Program, and different pharmaceutical companies such as Pfizer Pharmaceutical Company.

The research collaborations with academic institutes in China were also supported by the National Natural Science Foundation of China and the Ministry of Science and Technology of Chinese Government.

Research areas/interest

Molecular and cellular biology, hepatic fibrosis, hepatocellular carcinoma, cholangiocarcinoma, cancer stem cells, siRNA nanoparticle delivery, natural product and traditional Chinese medicine.

Education/training background

1994 - 1997 Postdoctoral Fellow University of Manitoba (Supervisor: Dr. G.Y. Minuk)

1993 - 1994 Postdoctoral Fellow Mayo Clinic (Supervisor: Dr. D.J. Tindall)

1993 PhD University of Manitoba (Supervisor: Dr. L.J. Murphy)

1986 Master of Medicine Chinese Academy of Medical Sciences (Supervisor: Dr. S. Zhou)

1983 Bachelor of Medicine Beijing University of Traditional Chinese Medicine

Select publications and/or presentations

1. Refaat Omar, Jiaqi Yang, Samaa Alrushaid, Frank J. Burczynski, Gerald Y. Minuk and Yuewen Gong: Inhibition of BMP4 and alpha smooth muscle actin expression in LX-2 hepatic stellate cells by BMP4-siRNA lipid based nanoparticle. J Pharm Pharm Sci, 21 (0): 119-134, 2018. DOI: http://dx.doi.org/10.18433/jpps29584

2. Jiaqi Yang, Yuewen Gong, Ian Corbin, Gerald Y. Minuk: Effects of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles on Cancer Stem Cells Isolated from Human Hepatocellular Carcinoma Cell Lines. Molecular Biology Reports, in press 2018.

3. Ji H, Minuk GY, Peng Z, Chen Y, Pan C, Gong Y. Active Immunization against Transforming Growth Factor-beta1 Prevents Hepatic Fibrosis in a Rat Model of Liver Disease. Can J Physiol Pharmacol. 2017 Mar 16. doi: 10.1139/cjpp-2016-0669. [Epub ahead of print] PubMed PMID: 28301738.

4. Refaat Omar, Jiaqi Yang, Haoyun Liu, Neal M. Davies, Yuewen Gong: Hepatic stellate cells in liver fibrosis and siRNA-based therapy. Rev Physiol Biochem Pharmacol. 2016;172:1-37. DOI: 10.1007/112_2016_6. PubMed PMID: 27534415.

5. Haojun Zhang, Hua Wang, Meihua Yan, Tingting Zhao, Xiaoguang Lu, Bin Zhu, Yuewen Gong, Ping Li: A recombinant TGF-beta1 vaccine ameliorates diabetic nephropathy in OLETF rats. Immunotherapy. 2016 Sep;8(9):1045-57. doi: 10.2217/imt-2015-0005. PubMed PMID: 27485077.

6. Xi S, Shi M, Jiang X, Minuk GY, Cheng Y, Peng Y, Gong Y, Xu Y, Wang X, Yang J, Yue L, Wang Y. The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease. J Ethnopharmacol. 2016 Mar 2;180:28-36. doi: 10.1016/j.jep.2016.01.030. PubMed PMID: 26802785.

7. Xiaotong Wang, Qingguo Wang, Gerald Y. Minuk, Frank J. Burczynski, Weisi Kong, Emmanuel Ho, Yuewen Gong: Expression and Regulation of Bone Morphogenetic Protein 4 in Hepatocellular Carcinoma. Integrative Cancer Science and Therapeutics, 2015: 2(1): 70-74. doi: 10.15761/ICST.1000116.

8. Lanman Xu, Yuewen Gong, Benfu Wang, Keqing Shi, Yijun Hou, Liping Wang, Zuo Lin, Yixiang Han, Lu Lu, Dazhi Chen, Xiuli Lin, Qiqiang Zeng, Yongping Chen: A Randomized Trial of Autologous Bone Marrow Mesenchymal Stem Cells Transplantation for HBV Cirrhosis: Regulation of Treg/Th17 cells. J Gastroenterol Hepatol. 2014 Aug;29(8):1620-8. doi: 10.1111/jgh.12653.

9. Yu Gong, Guqi Wang, Yuewen Gong, Jing Yan, Yufei Chen and Frank J Burczynski: Hepatoprotective role of liver fatty acid binding protein in acetaminophen induced toxicity. BMC Gastroenterol. 2014 Mar 10;14:44.

10. Xiaotong Wang, Qingguo Wang, Frank J. Burczynski, Weisi Kong, Yuewen Gong: Regulation of bone morphogenetic protein 4 during hepatic stellate cell activation by Saikosaponin A. Phytomedicine 2013, 20:1330-1335.

11. Yuewen Gong.: Identifying the targets for treatment of liver fibrosis and hepatocellular carcinoma from both western medicine and traditional Chinese medicine, Chin J Integr Med. 2012 Apr;18(4):245-9. Epub 2012 Mar 30.

12. Yan J, Gong Y, She YM, Wang G, Roberts MS, Burczynski FJ. Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity. J Lipid Res. 2009 Dec;50(12):2445-54. Epub 2009 May 27. PubMed PMID: 19474456; PubMed Central PMCID: PMC2781316.

13. Fan J, Shen H, Dai Q, Minuk GY, Burzynski FJ, Gong Y: Bone morphogenetic protein-4 induced rat hepatic progenitor cell (WB-F344 cell) differentiation toward hepatocyte lineage through Smad1, ERK1/2 and C/EBP alpha. J Cell Physiol. 2009 Jul;220(1):72-81. PMID: 19229878 [PubMed - indexed for MEDLINE].

14. Shen H, Fan J, Burczynski FJ, Minuk GY, Cattini P, Gong Y: Increases Smad1 expression and transcriptional activity enhances transdifferentiation of hepatic stellate cells. J Cell Physiol. 2007 Sep:212(3):764-70. PMID: 17525996 [PubMed - indexed for MEDLINE]

15. Fan J, Li X, Li P, Li N, Wang T, Shen H, Siow Y, Choy P, Gong Y. Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol. 2007 Apr;85(2):189-95. PMID: 17534399 [PubMed - indexed for MEDLINE]

16. Sun Y, Fan J, Shen H, Li P, Cattini P, Gong Y. Cloning and promoter activity of rat Smad1 5'-flanking region in rat hepatic stellate cells. Mol Cell Biochem. 2007 Oct;304(1-2):227-34. Epub 2007 May 26. PMID: 17530186 [PubMed - in process]

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