His clinical interest concentrates on minimal invasive Pediatric General Surgery and his research focuses on congenital anomalies in general and congenital diaphragmatic hernia and pulmonary hypoplasia in particular. He has expertise in mechanisms of normal and abnormal lung development due to congenital diaphragmatic hernia (CDH). Currently, his laboratory focuses on the role of two microRNAs: miR-10a and miR-200b during normal and abnormal lung development due to CDH. In the near future he wants to explore methods for prenatal therapeutic intervention to modulate the natural course of pulmonary hypoplasia and CDH to improve the outcome of babies born with this anomaly.
1. R. Kholdebarin, B.M. Iwasiow, R. Keijzer (2011) Pulmonary development considerations in the surgical management of congenital diaphragmatic hernia. Early Hum. Dev. 87 (11):755-8.
2. R. van Loenhout, I. Tseu, E. Fox, Z. Huang, D. Tibboel, M. Post, R. Keijzer (2012) The pulmonary mesenchymal cell layer is defective in congenital diaphragmatic hernia. Am. J. Path. 180(1):48-60.
3. R. Keijzer, E.D. Wilschut, R.J. Houmes, C.P. van de Ven, L.van den Hout, I. Sluijter, P. Rycus, N.M.A. Bax, D. Tibboel (2012) Congenital diaphragmatic hernia: to repair on or off ECMO? J. Ped. Surg. 47(4):631-6.
4. N. Khoshgoo, R. Kholdebarin, B. Iwasiow, R. Keijzer (2013) MicroRNAs and lung development. Ped. Pulm. 48(4):317-23.
5. R.B. van Loenhout, R.R. de Krijger, C.P. van de Ven, D. Tibboel, R. Keijzer (2013) Postmortem minimally invasive lung biopsy as an alternative to autopsy in newborns with congenital lung anomalies. Neonatology 103(3):213-217.
University of Manitoba
Professor - Department of Surgery
Thorlakson Chair in Surgical Research - Department of Surgery
Cross or adjunct appointments with other Departments
Department of Child Health & Pediatrics
Department of Physiology
Department of Surgery
Children's Hospital - Health Sciences Centre
Association with a Research Insititute
Children's Hospital Research Institute of Manitoba (CHRIM)
602 - John Buhler Research Centre
715 McDermot Avenue
Canada R3E 3P4
Phone (204) 787-8854
Fax (204) 787-1479
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