Richard Keijzer
Dr. Keijzer is the Thorlakson Chair in Surgical Research and Research Director for the Department of Surgery. He is also the Graduate Chair for the Master of Science Program in the Department of Surgery. He is a Pediatric Surgeon-Scientist and Professor of Surgery, Pediatrics & Child Health and Physiology (adjunct), and Scientist of the Manitoba Institute of Child Health, Biology of Breathing Group. Born and raised in The Netherlands, he did his clinical training (General Surgery and Pediatric Surgery) at ErasmusMC-Sophia in Rotterdam, The Netherlands and a fellowship in Pediatric Endoscopic Surgery in The Children’s Hospital of Alabama in Birmingham, Alabama. His research training consisted of a MSc and PhD at the departments of Pediatric Surgery and Cell Biology & Genetics of ErasmusMC in Rotterdam, The Netherlands and the Department of Lung Biology Research in the Hospital for Sick Children in Toronto. After completion of his General Surgery training he did a postdoctoral fellowship at the Department of Physiology & Experimental Medicine of the Hospital for Sick Children in Toronto.

Research Focus
His clinical interest concentrates on minimal invasive Pediatric General Surgery and his research focuses on congenital anomalies in general and congenital diaphragmatic hernia and pulmonary hypoplasia in particular. He has expertise in mechanisms of normal and abnormal lung development due to congenital diaphragmatic hernia (CDH). Currently, his laboratory focuses on the role of two microRNAs: miR-10a and miR-200b during normal and abnormal lung development due to CDH. In the near future he wants to explore methods for prenatal therapeutic intervention to modulate the natural course of pulmonary hypoplasia and CDH to improve the outcome of babies born with this anomaly.

1.   R. Kholdebarin, B.M. Iwasiow, R. Keijzer (2011) Pulmonary development considerations in the surgical management of congenital diaphragmatic hernia. Early Hum. Dev. 87 (11):755-8.

2.   R. van Loenhout, I. Tseu, E. Fox, Z. Huang, D. Tibboel, M. Post, R. Keijzer (2012) The pulmonary mesenchymal cell layer is defective in congenital diaphragmatic hernia. Am. J. Path. 180(1):48-60.

3.   R. Keijzer, E.D. Wilschut, R.J. Houmes, C.P. van de Ven, L.van den Hout, I. Sluijter, P. Rycus, N.M.A. Bax, D. Tibboel (2012) Congenital diaphragmatic hernia: to repair on or off ECMO? J. Ped. Surg. 47(4):631-6.

4.   N. Khoshgoo, R. Kholdebarin, B. Iwasiow, R. Keijzer (2013) MicroRNAs and lung development. Ped. Pulm. 48(4):317-23.

5.   R.B. van Loenhout, R.R. de Krijger, C.P. van de Ven, D. Tibboel, R. Keijzer (2013) Postmortem minimally invasive lung biopsy as an alternative to autopsy in newborns with congenital lung anomalies. Neonatology 103(3):213-217.

University of Manitoba
Professor - Department of Surgery
Thorlakson Chair in Surgical Research - Department of Surgery

Cross or adjunct appointments with other Departments
Department of Child Health & Pediatrics
Department of Physiology

Current position
Pediatric Surgeon
Department of Surgery
Children's Hospital - Health Sciences Centre

Association with a Research Insititute
Children's Hospital Research Institute of Manitoba (CHRIM)


602 - John Buhler Research Centre
715 McDermot Avenue
Winnipeg Manitoba
Canada    R3E 3P4

Phone     (204) 787-8854
Fax           (204) 787-1479

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