Dr. Modirrousta is the director of the Neuromodulation and Neuropsychiatry Unit at St. Boniface Hospital, where she uses neuropsychological and neurocognitive tools as well as repetitive transcranial magnetic stimulation (rTMS) to study the link between the brain and behaviour in a variety of neuropsychiatric disorders. In 2010, she received the Association of Chairs of Psychiatry in Canada research award and the American Psychiatric Association award (Research Colloquium for Junior Investigators). She also received several best presentation and best paper awards during her residency at the University of Manitoba.
One of Dr. Modirrousta’s main research interests is understanding the mechanisms of compulsive behaviours in Obsessive Compulsive Disorder and Frontotemporal Neurocognitive Disorder. She applies rTMS as a possible treatment intervention for these conditions. In addition, her lab is investigating biological signatures of rTMS treatment-response in neuropsychiatric disorders including depression.
Her clinical interest is exploring the concept of ‘cognitive rehabilitation’ – through cognitive training and rTMS therapy – in a variety of mild to moderate neurocognitive disorders including post-concussion syndrome and the early stages of neurodegenerative disorders.
For more information about ongoing projects in the Neuromodulation and Neuropsychiatry Unit at St. Boniface Hospital, please follow the link: www.neuromodulationunit.com
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Campbell DW, Wallace MG, Modirrousta M, Polimeni JO, McKeen NA, Reiss JP. The neural basis of humour comprehension and humour appreciation: The roles of the temporoparietal junction and superiror frontal gyrus. Neuropsychologia. 2015 Oct 13. pii: S0028-3932(15)30190-1 PMID 26474740
Modirrousta M, Meek BP, Sareen J, Enns MW. Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation. BMC Neurosci. 2015 Oct 9;16(1):63 PMID 26453446
Modirrousta M, Meek BP, Sareen J, Enns MW., "Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation." BMC Neurosci. 2015 Oct 9;16(1):63. PMID: 26453446
Dhaliwal S, Meek B, Modirrousta M., "Non-Invasive Brain Stimulation for the Treatment o Symptoms Following Traumatic Brain Injury." Front. Psychiatry, 26 August 2015.
Modirrousta M, Shams E, Katz C, Mansouri B, Moussavi Z, Sareen J, Enns M., "The Efficacy of Deep Repetitive Transcranial Magnetic Stimulation Over the Medial Prefrontal Cortex in Obsessive Compulsive Disorder: Results from an Open-Label Study.”, Journal of Depression and Anxiety, 2015 March 31 PMID 25826717.
Modirrousta M, Fellows LK, Dickerson B., "Stimulus-Value and Action-Value Learning in Patients with Frontotemporal Dementia”, Journal of Neuropsychiatry and Clinical Neuroscience, 2014; 26;179-183.doi:10.1176/appi.neuropsych.262abstract
Modirrousta, M., Dickerson B. and Price Bruce, Neuropsychiatric symptoms in Primary Progressive Aphasia: Phenomenology, pathophysiology, and approach to assessment and treatment. (Neurodegenerative Dis. management, April 2013, Vol. 3, No. 2, Pages 133-146)
Modirrousta, M., Shams E., Mansouri B., Moussavi Z., Catz C., Sareen J. and Enns M. The efficacy of deep repetitive transcranial magnetic stimulation over the medial prefrontal cortex in obsessive compulsive disorder, Poster/podium presentation, Oct., 2012, Society for Neuroscience. (submitted) Mandana Modirrousta and Lesley K. Fellows. Dorsal medial prefrontal cortex plays a necessary role in rapid error prediction in human. Journal of Neuroscience, 28 (51), 2008
Mandana Modirrousta and Lesley K. Fellows. Is medial prefrontal cortex necessary for the sensation of mental effort? Poster presentation, Cognitive neuroscience Society Annual Meeting, 2008, San Francisco, CA.
Mandana Modirrousta and Lesley K. Fellows. Medial prefrontal cortex plays a critical and selective role in the ‘feeling of knowing’ component of meta-memory. Neuropsychologia,46(12) , 2008
Mandana Modirrousta, Lynda Mainville and Barbara E Jones. Dynamic changes in GABAA receptors on basal forebrain cholinergic neurons following sleep deprivation and recovery. (BMC-series journals, Volume 8:15, 2007).