Mandana Modirrousta, MD, PhD, FRCPC
Dr. Modirrousta is an Assistant Professor at the University of Manitoba in the Department of Psychiatry. She completed her residency in psychiatry at the University of Manitoba in 2012 before pursuing a fellowship in clinical neuropsychiatry at Massachusetts General Hospital, Harvard Medical School. Prior to her residency, Dr. Modirrousta earned a PhD in neuroscience from the Montreal Neurological Institute at McGill University and completed post-doctoral training in cognitive neuroscience and behavioral neurology. She is certified in the subspecialty of Behavioural Neurology and Neuropsychiatry by the United Council of Neurologic Subspecialties.

Dr. Modirrousta is the director of the Neuromodulation and Neuropsychiatry Unit at St. Boniface Hospital, where she uses neuropsychological and neurocognitive tools as well as repetitive transcranial magnetic stimulation (rTMS) to study the link between the brain and behaviour in a variety of neuropsychiatric disorders. One of Dr. Modirrousta’s main research interests is understanding the mechanisms of compulsive behaviours in Obsessive Compulsive Disorder and Frontotemporal Neurocognitive Disorder. She applies rTMS as a possible treatment intervention for these conditions. In addition, her lab is investigating biological signatures of rTMS treatment-response in neuropsychiatric disorders including depression.

Her clinical interest is exploring the concept of ‘cognitive rehabilitation’ – through cognitive training and rTMS therapy – in a variety of mild to moderate neurocognitive disorders including post-concussion syndrome and the early stages of neurodegenerative disorders.

In 2010, she received the Association of Chairs of Psychiatry in Canada research award and the American Psychiatric Association award (Research Colloquium for Junior Investigators). In 2017 she was awarded the Aubie Young Investigator Award for Clinical Research by the University of Manitoba.

For more information visit the Neuromodulation and Neuropsychiatry Unit Webpage

Follow Neuromodulation and Neuropsychiatry Unit on Twitter at @BrainMattersMb

Selected publications:

Modirrousta M, Meek BP, Wikstrom S. (2018). The efficacy of twice-daily versus once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder. Journal of Neuropsychiatric Disease and Treatment. 14:309-316. PMID: 29398915

Tachere OR, Modirrousta M. (2017). Beyond Anxiety and Agitation: A Clinical Approach to Akathisia. Australian Family Physician. 46(5):296-298. PMID: 28472575

Milev RV, Giacobbe P, Kennedy SH, Blumberger DM, Daskalakis ZJ, Downar J, Modirrousta M, Patry S, Vila-Rodriguez F, Lam RW, MacQueen GM, Parikh SV, Ravindran AV; CANMAT Depression Work Group. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments. Canadian Journal of Psychiatry. 61(9):561-75. PMID: 27486154

Campbell DW, Wallace MG, Modirrousta M, Polimeni JO, McKeen NA, Reiss JP. (2015). The neural basis of humour comprehension and humour appreciation:  The roles of the temporoparietal junction and superiror frontal gyrus.  Neuropsychologia. 79:10-20. PMID 26474740

Modirrousta M, Meek BP, Sareen J, Enns MW. (2015). Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation.  BMC Neuroscience. 16:63 PMID 26453446

Dhaliwal S, Meek Bp, Modirrousta M. (2015). Non-Invasive Brain Stimulation for the Treatment of Symptoms Following Traumatic Brain Injury. Frontiers in Psychiatry. 6:119. PMID: 26379560

Modirrousta M, Shams E, Katz C, Mansouri B, Moussavi Z, Sareen J, Enns M. (2015). The Efficacy of Deep Repetitive Transcranial Magnetic Stimulation Over the Medial Prefrontal Cortex in Obsessive Compulsive Disorder: Results from an Open-Label Study. Depression and Anxiety. 32(6):445-50. PMID 25826717.

Modirrousta M, Price BH, Dickerson BC. (2013). Neuropsychiatric symptoms in Primary Progressive Aphasia: Phenomenology, pathophysiology, and approach to assessment and treatment. Neurodegenerative Disorder Management. 3(2):133-146. PMID: 23997827

Modirrousta M, Fellows LK. (2008). Dorsal medial prefrontal cortex plays a necessary role in rapid error prediction in human. Journal of Neuroscience. 28(5):14000-5. PMID: 19091989

Modirrousta M, Fellows LK. (2008). Medial prefrontal cortex plays a critical and selective role in the ‘feeling of knowing’ component of meta-memory. Neuropsychologia. 46(12):2958-65. PMID: 18606176

Modirrousta M, Mainville L, Jones BE. (2004). Gabaergic neurons with alpha2-adrenergic receptors in basal forebrain and preoptic areas express c-Fos during sleep. Neuroscience. 129(3):803-10. PMID: 15541901

University Rank: Assistant Professor
Clinical/Academic/Administrative Responsibilities
Neuromodulation/Neurostimulation Laboratory
Department of Psychiatry
University of Manitoba
Contact Information
M5 McEwen - St. Boniface Hospital
351 Tache Avenue, Winnipeg MB, R2H 2A6
(Phone) 204-237-2606
(Fax) 204-233-8051