Dr. Vernon Dolinsky

Associate Professor
Department of Pharmacology and Therapeutics
Children’s Hospital Research Institute of Manitoba
601 John Buhler Research Centre
715 McDermot Avenue
University of Manitoba
Winnipeg, MB
204-789-3559
vdolinsky@chrim.ca
PubMed

 

Research Focus:

My research is focused on the mechanisms that predispose youth for the development of obesity, diabetes and related cardiovascular disorders.

The World Health Organization estimated that 17 million people die annually from cardiovascular diseases globally, more than from any other cause of death. In the U.S., cardiovascular disease accounts for 1 in 3 of all deaths. Of significant concern is the growing number of individuals who are overweight or obese, since diseases such as diabetes are associated with obesity. Currently, 150 million individuals in the U.S. are overweight and 18 million have been diagnosed with diabetes as well as a further 7 million have undiagnosed diabetes, representing a total of approximately 11% of the population. Obesity and diabetes are important predictors of cardiovascular morbidity and mortality, particularly left ventricular hypertrophy, myocardial infarction, congestive heart failure and renal failure. This is particularly important in light of the fact that the rising incidence of overweight and obese children that are developing diabetes presents a significant clinical problem for the future.

My research program studies how complications during pregnancy increase the risk for early-onset obesity, diabetes and cardiovascular disease in the offspring. One of the most common complications during pregnancy is diabetes, which results in high blood sugar and insulin levels in pregnant mothers. These and additional factors have major effects on the growth and development of the fetus. My research explores the biological processes that cause children from pregnancies complicated by diabetes to be at higher risk for obesity, diabetes, and cardiovascular disease later in life. I am currently developing animal models to study this phenomenon.

The research projects also involve molecular biology approaches to study the fundamental mechanisms that program whole body energy homeostasis and cardiovascular function during pregnancy. We test pharmacologic interventions and gene therapies to treat these metabolic disorders both during pregnancy and following birth. Working as an interdisciplinary team with population health researchers and clinicians at the Children’s Hospital Research Institute of Manitoba, we hope that the outcome of these experiments will be novel early life biomarkers of disease, new treatments and better follow-up care for both mothers and children.

 

 

Publications: PubMed

Diabetes Research Envisioned and Accomplished in Manitoba Research Theme: http://www.dreamdiabetesresearch.com/

Developmental Origins of Chronic Diseases in Children Network (DEVOTION): https://www.devotionnetwork.com/

 

 

Dr. Dolinsky

Dr. Vernon W. Dolinsky

My research is focused on the mechanisms that predispose youth for the development of obesity, diabetes and related cardiovascular disorders.

Ken Hughes Young Investigator Award for Medical Research 2016

University of Manitoba and the University of Manitoba Faculty Association Merit Award 2016

Diabetes Foundation of Manitoba, Dr. J.A. Moorhouse Fellowship Award 2014-2017

Stewart Whitman-Amgen Young Investigator Award 2014

 

Canadian Institutes of Health Research (CIHR)
Dr. Vernon Dolinsky
Title: The developmental origins of obesity and obesity-related complications in children.
Grant Amount: $2,000,000 from Canadian Institutes of Health Research
January 1, 2016 to December 31, 2020

Dr. Vernon Dolinsky
Title: Adiponectin in gestational diabetes and the developmental origins of disease
Grant Amount: $503,599.00 from Canadian Institutes of Health Research
October 1, 2014 to September 30, 2019

Dr. Vernon Dolinsky
Title: The regulation of cardiac mitochondrial homeostasis in heart failure by SIRT3.
Grant Amount: $287,702 from Heart and Stroke Foundation of Canada
July 1, 2016 to June 30, 2019

Dr. Vernon Dolinsky
Grant Amount: $100,000.00 from Manitoba Health Research Council
September 1, 2013 to August 31, 2016