Dr. Ruey-Chyi Su
  Adjunct Professor of Medical Microbiology, University of Manitoba
Head: HIV Immunogenetics & Epigenetics, National Laboratory for HIV Immunology, National HIV and Retrovirology Laboratories, Public Health Agency of Canada
Degrees: B. Sc. (Hons.), PhD., University of Toronto

Mailing Address: National Microbiology Laboratory 1015 Arlington Avenue, Winnipeg, MB R3E 3R2 Canada
Lab/Office Address: JC Wilt Infectious Diseases Research Centre 745 Logan Ave., Winnipeg, MB R3E 3L5 Canada

Tel: 204-789-6474, Fax: 204-318-2221
E-mail: rueysu@gmail.comrueyc.su@canada.ca

Currently looking for Master Students who are interested in examining the impacts of pathogen on the epigenomes of human cells, using transcriptomic and epigenomic approaches (Feb 2018)

Research Interests: My main research focus has been to understand the molecular mechanisms facilitating the interaction of gene-regulation and environment (e.g., health, inflammation, infection) in disease susceptibility, vaccination and treatment. My research group has two main goals: (1) To define the regulation of innate immunity (interferon pathways) by genetic and environmental (epigenetic) factors, and examine their roles in susceptibility to infection. This study aims at identifying mechanisms of protection against HIV-infection and potential innate adjuvants for optimized vaccination. (2) To define the molecular impacts of HIV-infection on the regulation of host innate immunity and the gene expression of infected cell. This study aims at identifying markers for latent HIV-infected cells, and the altered expression and function of innate immunologic factors in HIV-infected patients.

         

Current Research Group             Role Project / Skills
Bernard Abrenica Technical Support Bioinformatics, Confocal Imaging, Molecular Assays, Genotyping hFcR
Angela Harris M.Sc . Candidate Role of IRF-1 and IRF-7 in susceptibility to viral infection.
Andrew Plensniarski M.Sc. Candidate Defining the molecular mechanisms underlying the hormonal regulation of innate immune factors
Daniel Udenwobele M.Sc. Candidate
(U of Winnipeg)
Co-supervised with Dr. A. Shrivastav
Characterizing the impacts of HIV-infection on mTOR signaling (including NMT-1) in immunologic cells.
Arvelene Camama Research Student Establishing in-vitro model of HIV-1 latency for identifying the effects of infection on host gene regulation.

For a list of Dr. Su's PubMed articles, please click here

Recent Publications:
Feng D, Su RC, Zou L, Triggs-Raine B, Huang S, Xie J. Increase of a group of PTC(+) transcripts by curcumin through inhibition of the NMD pathway. Biochim Biophys Acta. 2015 Apr 29. pii: S1874-9399(15)00089-9. doi:10.1016/j.bbagrm.2015.04.002. [Epub ahead of print] PubMed PMID: 25934542.

Sivro A, Su RC, Plummer FA, Ball TB. Interferon responses in HIV infection: from protection to disease. AIDS Rev. 2014 Jan-Mar;16(1):43-51. PubMed PMID: 24522779.

Sivro A, Su RC, Plummer FA, Ball TB. HIV and interferon regulatory factor 1: a story of manipulation and control. AIDS Res Hum Retroviruses. 2013 Nov;29(11):1428-33. doi: 10.1089/AID.2013.0098. Epub 2013 Sep 25. Review. PubMed PMID: 23984938.

Sivro A, McKinnon LR, Ji H, Kimani J, Jaoko W, Plummer FA, Su RC, Ball TB. Interferon regulatory factor 1 polymorphisms previously associated with reduced HIV susceptibility have no effect on HIV disease progression. PLoS One. 2013 Jun 14;8(6):e66253. doi: 10.1371/journal.pone.0066253. Print 2013. PubMed PMID: 23799084; PubMed Central PMCID: PMC3683001.

Xie J, Lotoski LC, Chooniedass R, Su RC, Simons FE, Liem J, Becker AB, Uzonna J, HayGlass KT. Elevated antigen-driven IL-9 responses are prominent in peanut allergic humans. PLoS One. 2012;7(10):e45377. doi: 10.1371/journal.pone.0045377. Epub 2012 Oct 11. PubMed PMID: 23071516; PubMed Central PMCID: PMC3469559.

Su RC, Sivro A, Kimani J, Jaoko W, Plummer FA, Ball TB. Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals. Blood. 2011 Mar 3;117(9):2649-57. doi: 10.1182/blood-2010-10-312462. Epub 2011 Jan 3. PubMed PMID: 21200019; PubMed Central PMCID: PMC3062355.

Earlier Publications:

Su RC, Becker AB, Kozyrskyj AL, Hayglass KT. Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children. J Allergy Clin Immunol. 2009 Nov;124(5):1116-8. doi:10.1016/j.jaci.2009.08.033. PubMed PMID: 19895998.

Douville RN, Su RC, Coombs KM, Simons FE, Hayglass KT. Reovirus serotypes elicit distinctive patterns of recall immunity in humans. J Virol. 2008 Aug;82(15):7515-23. doi: 10.1128/JVI.00464-08. Epub 2008 May 28. PubMed PMID: 18508904; PubMed Central PMCID: PMC2493337.

Su RC, Becker AB, Kozyrskyj AL, Hayglass KT. Epigenetic regulation of established human type 1 versus type 2 cytokine responses. J Allergy Clin Immunol. 2008 Jan;121(1):57-63.e3. Epub 2007 Nov 5. PubMed PMID: 17980413.

Su RC, Sridharan R, Smale ST. Assembly of silent chromatin during thymocyte development. Semin Immunol. 2005 Apr;17(2):129-40. Review. PubMed PMID: 15737574.

Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale ST. Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet. 2004 May;36(5):502-6. Epub 2004 Apr 18. PubMed PMID: 15098035.

Kawamura KS, Su RC, Nguyen LT, Elford AR, Ohashi PS, Gariépy J. In vivo generation of cytotoxic T cells from epitopes displayed on peptide-based delivery vehicles. J Immunol. 2002 Jun 1;168(11):5709-15. PubMed PMID: 12023370.

Su RC, Miller RG. Stability of surface H-2K(b), H-2D(b), and peptide-receptive H-2K(b) on splenocytes. J Immunol. 2001 Nov 1;167(9):4869-77. PubMed PMID: 11673491.

Kung SK, Su RC, Shannon J, Miller RG. Characterization of four new monoclonal antibodies that recognize mouse natural killer activation receptors. Hybridoma. 2001 Apr;20(2):91-101. PubMed PMID: 11394535.

Rabinovich BA, Shannon J, Su RC, Miller RG. Stress renders T cell blasts sensitive to killing by activated syngeneic NK cells. J Immunol. 2000 Sep 1;165(5):2390-7. PubMed PMID: 10946262.

Su RC, Kung SK, Silver ET, Lemieux S, Kane KP, Miller RG. Ly-49CB6 NK inhibitory receptor recognizes peptide-receptive H-2Kb. J Immunol. 1999 Nov 15;163(10):5319-30. PubMed PMID: 10553055.

Kung SK, Su RC, Shannon J, Miller RG. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. J Immunol. 1999 May 15;162(10):5876-87. PubMed PMID: 10229823.

Su RC, Kung SK, Gariépy J, Barber BH, Miller RG. NK cells can recognize different forms of class I MHC. J Immunol. 1998 Jul 15;161(2):755-66. PubMed PMID: 9670952.

Kung SK, Su RC, Graham JJ, Chamberlain JW, Miller RG. NK cells from human MHC class I (HLA-B) transgenic mice do not mediate hybrid resistance killing against parental nontransgenic cells. J Immunol. 1998 Jan 15;160(2):674-80. PubMed PMID: 9551902.

Takhar S, Gyomorey S, Su RC, Mathi SK, Li X, Wheeler MB. The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system. Endocrinology. 1996 May;137(5):2175-8. PubMed PMID: 8612565.