Dr. Carla Osiowy
Carla Primary Affiliation:
Chief, Viral Hepatitis and Bloodborne Pathogens Section
National Microbiology Laboratory, Public Health Agency of Canada
Canadian Science Centre for Human and Animal Health (CSCHAH)
1015 Arlington Street
Winnipeg, MB, R3E 3R2

Ph: (204)-789-6061
Fax: (204)-789-2082
email: carla.osiowy@canada.ca
Research Interests:

Molecular characterization of hepatitis B virus (HBV) and hepatitis D virus (HDV): investigation of HBV and HDV genotypes, drug-resistant and immune-escape mutants; molecular epidemiology of HBV and HDV infection; investigation of occult HBV; HBV molecular evolution; investigation of HBV and HDV in indigenous populations of the circumpolar Arctic; HAV molecular epidemiology in Canada

Recent Publications:

For a list of Dr. Osiowy's publications, please click here

1. Kanji, J.N., Penner, R.E.D., Giles, E., Goodison, K., Martin, S.R., Marinier, E., Osiowy, C. (2019) Horizontal transmission of hepatitis B virus from mother to child due to immune escape despite immunoprophylaxis. Journal of Pediatric Gastroenterology and Nutrition, in press (doi: 10.1097/MPG.0000000000002318).
2. Lau, K.C.K., Osiowy, C., Coffin, C.S. (2019) Hepatitis B virus (HBV) genome detection and genotyping in virally suppressed patients using nested polymerase chain reaction based Sanger sequencing. Diagnostic Microbiology and Infectious Disease 93:318-324.
3. Bautista, W., Osiowy, C., Klein, J., Minuk, G.Y. (2019) Hepatitis B Virus Infection of Normal Hepatic Stem/Progenitor Cells. Journal of Clinical and Experimental Hepatology 9:34-42.
4. Clinical Practise Guidelines Committee (Co-Chairs: Coffin, C.S., Fung, S.K.; Committee Authors alphabetical: Alvarez, F., Cooper, C.L., Doucette, K.E., Fournier, C., Kelly, E., Ko, H.H., Ma, M.M., Martin, S.R., Osiowy, C., Ramji, A., Tam, E., Villeneuve, J.P.) (2018) Management of Hepatitis B Virus Infection: 2018 Guidelines from the Canadian Association for the Study of Liver Disease and Association of Medical Microbiology and Infectious Disease Canada. Canadian Liver Journal 1(4): 156-217.
5. Lau, K.C., Osiowy, C., Giles, E., Lusina, B., van Marle, G., Burak, K.W., Coffin, C.S. (2018) Deep Sequencing Shows Low Level Oncogenic Hepatitis B Virus Variants Persisting Post-Liver Transplant Despite Potent Anti-HBV Prophylaxis. Journal of Viral Hepatitis 25:724-732.
6. O’Neil, C.R., Congly, S.E., Rose, M.S., Lee, S.S., Borman, M.A., Charlton, C.L., Osiowy, C., Swain, M.G., Burak, K.W., Coffin, C.S. (2018) Long-Term Follow-up and Quantitative Hepatitis B Surface Antigen Monitoring in North American Chronic HBV Carriers. Annals of Hepatology17:232-241.
7. Gao, S., Joshi, S., Osiowy, C., Chen, Y., Coffin, C.S., Duan, Z. (2017) Chronic Hepatitis B Carriers with Acute on Chronic Liver Failure Show Increased HBV Surface Gene Mutations, including Immune Escape Variants. Virology Journal 14:203.
8. Bouckaert, R., Simons, B.C., Krarup, H., Friesen, T.M., and Osiowy, C. (2017) Tracing hepatitis B virus (HBV) genotype B5 (formerly B6) evolutionary history in the circumpolar Arctic through phylogeographic modelling. PeerJ 5:e3757.
9. Huynh, C., Minuk, G.Y., Uhanova, J., Baikie, M., Wong, T., Osiowy, C. (2017) Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada. Vaccine 35:4515-4522.
10. Gao, S., Duan, Z., Chen, Y., van der Meer, F., Lee, S.S., Osiowy, C., van Marle, G., Coffin, C.S. (2017) Compartmental HBV evolution and replication in liver and extrahepatic sites after nucleos/tide analogue therapy in chronic hepatitis B carriers. Journal of Clinical Virology 94:8-14.
11. Osiowy, C., Andonov, A., Fonseca, K., Swidinsky, K., Giles, E., Mason, A., Coffin, C.S. (2017) Transmission of hepatitis D virus between spouses: a longitudinal study of the first reported Canadian case. IDCases 8:37-41.
12. Osiowy, C. (2018) From Infancy and Beyond… Ensuring a lifetime of hepatitis B virus (HBV) vaccine-induced immunity. Human Vaccines and Immunotherapeutics 11:1-5.
13. Osiowy, C., Coffin, C., and Andonov, A. (2016) Review of laboratory tests used in monitoring hepatitis B response to pegylated interferon and nucleos(t)ide analog therapy. Current Treatment Options in Infectious Disease 8:177-193.
14. Osiowy, C., Kowalec, K., and Giles, E. (2016) Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant. Diagnostic Microbiology and Infectious Disease 85(3):328-333.
15. Ochwoto, M., Kimotho, J.H., Oyugi, J., Okoth, F., Kioko, H., Mining, S., Budambula, N.L.M., Giles, E., Andonov, A., Songok, E., and Osiowy, C. (2016) Hepatitis B infection is highly prevalent among patients presenting with jaundice in Kenya. BMC Infectious Diseases 16(1):101.

Laboratory Members:


Ms. Alicia Vachon      MSc student (Sept 2019)
Ms. Elizabeth Giles    Research Technician    (204) 789 6033
Ms. Jacqueline Day    Research Technician    (204) 789 7065
Mr. Ken Swidinsky    Research Technician    (204) 784 5921
Ms. Jamie Borlang     Research Technician    (204) 789 2146
Mr. Tyler Kosowan    Research Technician    (204) 789 2055

Student position available? No.