|Research Council Officer, NRC-CNRC Institute for Biodiagnostics.|
Adjunct Professor, Department of Physics, Faculty of Science, University of Manitoba.
Degrees: Drs. (Leiden, 1985), Ph.D. (Dalhousie, 1989)
Mailing Address: NRC-CNRC Institute for Biodiagnostics, MR Technology group, 435 Ellice Avenue, Winnipeg, MB, R3B 1Y6.
Tel: (204) 984 6563 Fax: (204) 984 7036
The development and application of advanced in vivo MR imaging techniques to study disease in general. Magnetic resonance imaging (MRI) and spectroscopy (MRS) can be used to monitor the development of chronic fatal conditions, such as hepatocellular carcinoma (liver cancer) spongiform encephalopies, or Alzheimer's disease. MRI and MRS are non-invasive techniques and can be used to identify biomarkers for disease. This information could potentially be used to test novel drug treatments. Research at the National Research Council Institute for Biodiagnostics (NRC-IBD) focuses on the development and commercialization of innovative medical devices and technologies for the non-invasive diagnosis of diseases in humans and animals. NRC-IBD research is based on various imaging and spectroscopic modalities, prototyping, biomedical informatics, and medical software. NRC-IBD offers collaborative opportunities in the medical device, biotechnology and pharmaceutical industries
Additional information on research at IBD can be found at: http://ibd.nrc-cnrc.gc.ca/research/index_e.html
- B. Tomanek, V. Volotovskyy, M.L.H.Gruwel, E. McKenzie, S.B. King, Double Frequency Birdcage Volume Coils for 4.7T and 7T. Concepts Magn. Reson., 26 B(1), 16-22 (2005).
- E.J McKenzie, M. Jackson, J. Sun, V. Volotovskyy, M.L.H. Gruwel. Monitoring
the development of hepatocellular carcinoma in woodchucks using 31P MRS. MAGMA 18, 201 (2005).
- P. Latta, M.L.H. Gruwel, V. Volotovskyy, M.H. Weber, B. Tomanek, Simple phase method for measurement of magnetic field gradient waveforms. Magn. Reson. Imag. 25, 1272 (2007).
- P. Latta, M.L.H. Gruwel, V. Volotovskyy, M.H. Weber, B. Tomanek, Single Point Imaging with a variable phase encoding interval. Magn. Reson. Imag. 26, 109-116 (2008).
- M.L.H. Gruwel, P. Latta, M. Tanasiewicz, V. Volotovskyy, M. Sramek, B. Tomanek, MR Imaging of teeth using a silent Single Point Imaging technique. Appl. Phys. A. 88, 763 (2007).
- V. Volotovskyy, M.L.H.Gruwel, B.Blasiak, B. Tomanek, A Multi Frequency Narrow Band Pass Filter. Concepts Magn. Reson. B. 33(3) 145-151 (2008).
- Y. Yang, M.L.H. Gruwel, J. Sun, P. Gervai, X. Yang, V.V. Kupriyanov, Manganese- Enhanced MRI of Acute Cardiac Ischemia and Chronic Infarction in Pig Hearts: Kinetic Analysis of Enhancement Development. NMR Biomed. NMR Biomed. 22 (2), 165-173 (2009).
- M.L.H. Gruwel, Y. Yang, P. de Gervai, J. Sun, V.V. Kupriyanov. Magnetic resonance imaging tracking of alginate beads used for drug delivery of growth factors at sites of cardiac damage. Magn. Reson. Imag. 27, 970-975 (2009).
- K. Malisza, C. Jones, M.L.H. Gruwel, D. Foreman, P. Fernyhough, N. Calcutt. Functional magnetic Resonance
Imaging of the spinal cord during sensory stimulation in diabetic rats. J. Magn. Reson. Imag. 30, 271-276 (2009).
- W.P. Weglarz, M.M. Tanasiewicz,M.L.H. Gruwel,B. Tomanek, MRI visualisation of moisture ingression into porous tissue of decayed teeth. Diffusion Fundamentals 10, 29.1-29-4 (2009).
- E. Lattova, E.J. McKenzie, M.L.H. Gruwel, V. Spicer, R. Goldman, H. Perreault. Mass Spectrometric study of N-glycans from serum of woodchucks with liver cancer. Rapid Comm. Mass. Spect. 23, 2983-2995(2009)