Dr. Alberto Severini

Assistant Professor, Medical Microbiology and Infectious Diseases.
Assistant Professor, Faculty of Pharmacy,
Chief, Viral Exanthemata and STD Section, National Microbiology Laboratory, Public Health Agency of Canada

Degrees: M.D., 1981 (Parma , Italy); Biochemistry and Clinical Chemistry, 1987
( arma , Italy).

Mailing Address:  Canadian Science Centre for Human and Animal Health 1015 Arlington Street, Winnipeg , MB , R3E 3R2

Tel: (204) 789-6022; Fax: (204) 789-2140; Lab: (204)789-6024
E-mail: Alberto.Severini@phac-aspc.gc.ca

Research Interests:
Human papillomavirus testing and molecular epidemiology. Viral molecular diagnostics. Whole genome sequencing and surveillance of measles, mumps and rubella.  Genomics of herpesviruses. Herpesvirus replication and pathogenesis mechanisms.

Recent Publications:

For a list of Dr. Severini's publications, please click here

1. Awua AK, Adanu RMK, Wiredu EK, Afari EA, Severini A. Differences in age-specific HPV prevalence between self-collected and health personnel collected specimen in a cross-sectional study in Ghana. Infect Agent Cancer. 2017;12:26. doi: 10.1186/s13027-017-0136-728529541.
2. Awua AK, Adanu RMK, Wiredu EK, Afari EA, Zubuch VA, Asmah RH, Severini A. Unique LCR variations among lineages of HPV16, 18 and 45 isolates from women with normal cervical cytology in Ghana. Virol J. 2017 14:85. doi: 10.1186/s12985-017-0755-z.
3. Pabbaraju K, Wong S, Gill K, Severini A, Roy F, Gratrix J, Singh AE, Naidu P, Read R, Drews SJ. Use of the APTIMA Combo 2 Assay and a Secondary Algorithm to Detect and Confirm Chlamydia trachomatis in Rectal-Only Infections. Sex Transm Dis. 2017;44:118-119.
4. Zehbe I, Jackson R, Wood B, Weaver B, Escott N, Severini A, Krajden M, Bishop L, Morrisseau K, Ogilvie G, Burchell AN, Little J. Community-randomised controlled trial embedded in the Anishinaabek Cervical Cancer Screening Study: human papillomavirus self-sampling versus Papanicolaou cytology. BMJ Open. 2016 Oct 8;6(10):e011754. doi: 10.1136/bmjopen-2016-011754.
5. Binkhamis K, Gillis H, Lafreniere JD, Hiebert J, Mendoza L, Pettipas J, Severini A, Hatchette TF, LeBlanc JJ. Comparison of monoplex and duplex RT-PCR assays for the detection of measles virus.  J Virol Methods. 2017;239:58-60.
6. Roy F, Mendoza L, Hiebert J, McNall RJ, Bankamp B, Connolly S, Lüdde A, Friedrich N, Mankertz A, Rota PA, Severini A. Rapid identification of measles virus vaccine genotypes by real time PCR. J Clin Microbiol. 2016; 55:735-743.
7. Hatchette TF, Scholz H, Bolotin S, Crowcroft NS, Jackson C, McLachlan E, Severini A; Immunity of Canadians and Risk of Epidemics (iCARE) laboratory group and the Canadian Immunization Research Network (CIRN). Calibration and Evaluation of quantitative antibody titers for measles virus using the BioPlex 2200.  Clin Vaccine Immunol. 2017; 24: pii: e00269-16.
8. Charlton CL and  Severini A. (2016) Current Dilemmas and pitfalls in rubella laboratory diagnostics in low prevalence or elimination settings. Curr Treat  Options  Infect Dis. 2016; DOI 10.1007/s40506-016-0090-8
9. Jelen MM, et al. . Global genomic diversity of human papillomavirus type 11 (HPV11) based on 433 isolates and 78 complete genome sequences. J Virol. 2016; 90:5003-13.
10. Berard AR, Severini A, Coombs KM. Differential Reovirus-Specific an Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion. J Virol. 2015; 89:11954-64.
11. Gardy JL, Naus M, Amlani A, Chung W, Kim H, Tan M, Severini A, Krajden M, Puddicombe D, Sahni V, Hayden AS, Gustafson R, Henry B, Tang P. Whole-Genome Sequencing of Measles Virus Genotypes H1 and D8 During Outbreaks of Infection Following the 2010 Olympic Winter Games Reveals Viral Transmission Routes. J Infect Dis. 2015; 212:1574-8.
12. De Serres G, Desai S, Shane A, Hiebert J, Ouakki M, Severini A. Measles In Canada Between 2002 and 2013.Open Forum Infect Dis.2015; 2: ofv048.
13. Berard AR, Severini A, Coombs KM. Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways.Proteomics. 2015; 5:2113-35.
14. Berard AR, Coombs KM, Severini A. (. (2015). Quantification of the host response proteome after herpes simplex virus type 1 infection.J Proteome Res.14: 2121-42.
15. Totten S, MacLean R, Payne E, Severini A. Chlamydia and lymphogranuloma venereum in Canada: 2003-2012 Summary Report.Canada Communicable Disease Report. 2015;41(02)
16. Totten S, Severini A, Tohme S, Johnson G, Jayaraman GC ; Mao Y, Wong T, Sobol I. (2015). Typespecific oncogenic HPV and Pap findings in Inuit and non-Aboriginal women in Nunavut, Canada. Canada Communicable Disease Report. 14(03)

Laboratory Members:

Jennifer Beirnes Technician Jennifer.Beirnes@phac-aspc.gc.ca
Kerry Dust Grad Student dustk@myumanitoba.ca
Suzanne Gibbons Biologist suzanne.boudreau@phac-aspc.gc.ca
Joanne Hiebert Biologist joanne.hiebert@phac-aspc.gc.ca 
Dr. Elizabeth McLachlan Biologist elizabeth.mclachlan@phac-aspc.gc.ca
Lillian Mendoza Technician on leave
Leanne Scharikow Technician scharikow@phac-aspc.gc.ca
Helene Schulz Grad Student helene.schulz@phac-aspc.gc.ca
Sarah Tohme Technician on leave
Vanessa Zubach Technician on leave
Robyn Thorington Grad Student robyn.thorington@phac-aspc.gc.ca