Dr. Grant McClarty

Professor, Department of Medical Microbiology

Degrees: Ph.D. Microbiology (Manitoba, 1984)

Mailing Address: 504 Basic Medical Sciences Building
University of Manitoba
745 Bannatyne Avenue, Winnipeg, Manitoba,
Canada, R3E 0J9

Ph:  (204) 975-7708
Fax: (204) 789-3926

E-mail: grant.mcclarty@phac-aspc.gc.ca

Research Interests:
Chlamydia trachomatis(Ct) is an obligate intracellular eubacterial parasite. Ct consists of 12 serovars, designated A-K, including serovar Ba.  Infection with serovar A, B, Ba or C causes trachoma, the world’s leading cause of preventable blindness. Trachoma is one of the World Health Organization’s seven Neglected Tropical Diseases, defined as infectious diseases that principally impact the world's poorest people. Infection with any of the serovars D through K causes genital tract disease. Ct is now the most common sexually transmitted bacterial pathogen, an estimated 90 million cases occur each year worldwide. Our lab is interested in host/parasite interactions and employs genomics, cell and molecular biology approaches to understand chlamydial disease pathogenesis.

Recent Publications:

For a list of Dr. McClarty's PubMed articles, please click here

  1. Song L, Carlson JH, Whitmire WM, Kari L, Virtaneva K, Sturdevant DE, Watkins H, Zhou B, Sturdevant GL, Porcella SF, McClarty G, Caldwell HD. 2013 Chlamydia trachomatis Plasmid-Encoded Pgp4 Is a Transcriptional Regulator of Virulence-Associated Genes.Infect Immun. 81:636-44.
  2. Kari L, Goheen MM, Randall LB, Taylor LD, Carlson JH, Whitmire WM, Virok D, Rajaram K, Endresz V, McClarty G, Nelson DE, Caldwell HD. 2011. Generation of targeted Chlamydia trachomatis null mutants. Proc Natl Acad Sci U S A. 108:7189-93.
  3. Lutter EI, Bonner C, Holland MJ, Suchland RJ, Stamm WE, Jewett TJ, McClarty G, Hackstadt T. 2010. Phylogenetic analysis of Chlamydia trachomatis Tarp and correlation with clinical phenotype.Infect Immun. 78:3678-88.
  4. Kari L, Whitmire WM, Carlson JH, Crane DD, Reveneau N, Nelson DE, Mabey DC, Bailey RL, Holland MJ, McClarty G, Caldwell HD. 2008. Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations. J Infect Dis. 197:449-56.

 

Recent Patents:
3 Patents on monoclonal antibodies as therapeutic agents

Teaching Interests:
Bacterial virulence factors.  Host pathogen interactions.  The role of genomics in defining pathogen diversity.

Consulting Interests:
Translational research and Pharmaceutical/Biotech relations.