David Safronetz
 

Chief of Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada.

Degrees: B.Sc (U. Sask, 2000), M.Sc. (2003, U Manitoba), PhD (2009, U Manitoba).

Mailing Address: Zoonotic Diseases and Special Pathogens
National Microbiology Laboratory
Public Health Agency of Canada
1015 Arlington Street
Winnipeg, Manitoba R3E 3R2

Telephone: (204) 784-5998
Fax: (204) 789-2082
Email: david.safronetz@phac-aspc.gc.ca

Research Interests: My research interests are focused on the ecology, epidemiology and pathogenesis of emerging/re-emerging rodent-borne viruses with emphasis on hantaviruses and Lassa virus. These projects frequently involve a combination of field work as well as high containment (BSL 3,4) research.

Recent Publications:

1. Safronetz D, Lopez JE, Sogoba N, Traore’ SF, Raffel SJ, Fischer ER, Ebihara H, Branco L, Garry RF, Schwan TG, Feldmann H. 2010. Detection of Lass virus, Mali. Emerg. Infect. Dis. 16(7):1123-1126.

2. Safronetz D,  Zivcec M, LaCasse R, Feldmann F, Rosenke R, Long D, Haddock E, Brining D, Gardner D, Feldmann H, Ebihara H. 2011. Pathogenesis and host response of hantavirus pulmonary syndrome in Syrian hamsters following intranasal inoculation of Andes virus. PLoS Pathog. 7(12):e1002426.

3. Safronetz D, Falzarano D, Scott DP, Furuta Y, Feldmann H, Gowen BB. 2013. Antiviral efficacy of favipiravir against two prominent etiological agents of hantavirus pulmonary syndrome. Antimicrob. Agents. Chemother. 57(13):4673-4680.

4. Safronetz D, Sogoba N, Lopez JE, Maiga O, Dahlstrom E, Zivcec M, Feldmann F, Haddock E, Fischer RF,  Munster V, Branco L, Garry R, Porcella SF, Schwan TG, Feldmann H. 2013. Geographic distribution and genetic characterization of Lassa virus in Mali. PLoS Negl. Trop. Dis. 7(12):e2582.

5. Safronetz D, Prescott J, Feldmann F, Haddock E, Rosenke R, Brining D, Dahlstrom E, Porcella SF, Ebihara H, Scott DP, Hjelle B, Feldmann H. 2014. Pathophysiology of hantavirus pulmonary syndrome in Rhesus macaques. Proc. Natl. Acad. Sci. U.S.A. 111(19):7114-7119.
6. Marzi A, Feldmann F, Geisbert TW, Feldmann H, Safronetz D. 2015. Vesicular stomatitis virus-based vaccines against Lassa and Ebola viruses. Emerg. Infect. Dis. 21(2):305-307.

7. Hoenen T, Safronetz D, Groseth A, Wollenberg KR, Koita OA, Diarra B, Fall IS, Haidara HF, Diallo F, Sanogo M, Sarro YS, Kone A, Togo ACG, Traore A, Kodio M, Dosseh A, Rosenke K, de Wit E, Feldmann F, Ebihara E, Munster VJ, Zoon KC, Feldmann H, Sow S. 2015. Mutation rate and genotype variation of Ebola virus from Mali case sequences. Science. 348(6230):117-119.

8. Safronetz D, Rosenke K, Westover JB, Martellaro C, Okumura A, Furuta Y, Geisbert J, Saturday G, Geisbert TW, Komeno T, Feldmann H, Gowen BB. 2015. The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset. Sci Rep. 5, 14775; doi 10.1038/srep14775.

9. Sogoba N, Rosenke K, Adjemian J, Diawara SI, Maiga O, Keita M, Konate D, Keita AS, Sissoko I, Boisen M, Nelson D, Oottamasathien D, Millet M, Garry RF, Branco LM, Traore S, Doumbia S, Feldmann H, Safronetz D. 2016. Lassa virus seroprevalence in Sibirilia commune, Bougouni district in southern Mali. Emerg. Inf. Dis. 22(4):657-663.63.