Section of Neurology – Dr. Brian Schmidt

Professor, Department of Internal Medicine (Neurology), University of Manitoba.

Adjunct Professor, Department of Physiology and Pathophysiology, University of Manitoba

Research Coordinator Neurology Training Program

Degrees/Fellowship:  BSc (Med), MD, FRCPC

Mailing Address: Health Sciences Centre, GF543, 820 Sherbrook Street, Winnipeg, Manitoba, Canada  R3A 1R9

Tel: (204) 787- 4951; Fax: (204) 787-1486

E-mail: brian.schmidt@umanitoba.ca

Clinical Interests:
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General neurology
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Neuromuscular electrodiagnosis.

Research Interests:
A detailed understanding of the cellular and neural network properties giving rise to locomotion (i.e., walking) is essential in order to develop logical strategies aimed at restoring motor function after spinal cord injury.  Experiments in our laboratory involve a wide range of electrophysiological and neuropharmacological methods applied to isolated brainstem-spinal cord preparations (in vitro) from the rat as well as in vivo rodent models with selected spinal cord lesions.  This research, using lower mammalian models, is of direct relevance to human motor control, and takes place in the Spinal Cord Research Centre in the Department of Physiology.

Selected Publications:

Gawryluk JR, Ritchie LJ, Sicz G, Kilgour AR, Schmidt BJ.  A comprehensive neuropsychological assessment of a case of superficial siderosis.  Arch Clin Neuropsychil 1;32: 483-490, 2017.

Vosoughi R and Schmidt BJ.  Multifocal leukoencephalopathy in cocaine users: a report of two cases and review of the literature.  BMC Neurol 15:208 doi: 10.1186/s12883-015-0467-1, 2015.

Cowley KC, MacNeil BJ, Chopek JW, Sutherland S, Schmidt BJ. Neurochemical excitation of thoracic propriospinal neurons improves hindlimb stepping in adult rats with spinal cord lesions.  Exp Neurol. 264:174-87, 2015.

Sławińska U, Rossignol S, Bennett DJ, Schmidt BJ, Frigon A, Fouad K, Jordan LM.  Comment on "Restoring voluntary control of locomotion after paralyzing spinal cord injury". Science 338(6105):328, 2012.

Zaporozhets E, Cowley KCC, and Schmidt BJ.  Neurochemical excitation of propriospinal neurons facilitates locomotor command signal transmission in the lesioned spinal cord J. Neurophysiol. 105: 2818-2829, 2011.

Cowley KC, Zaporozhets E and Schmidt BJ.  Contribution of propriospinal neurons to the activation of locomotion.  Ann. N. Y. Acad. Sci. 1198: 42-53, 2010.

Cowley KC, Zaporozhets E, Joundi R and Schmidt BJ. Contribution of commissural projections to bulbospinal activation of locomotion in the in vitro neonatal rat spinal cord.  J. Neurophysiol.  101: 1171-8, 2009.

Cowley KC,  Zaporozhets E and Schmidt BJ.   Propriospinal neurons are sufficient for bulbospinal transmission of the locomotor command signal in the neonatal rat spinal cord.  J. Physiol.  586: 1623-1635, 2008.

Zaporozhets E, Cowley KC and Schmidt BJ.  Propriospinal neurons contribute to bulbospinal transmission of the locomotor command signal in the neonatal rat spinal cord.   J. Physiol.  572: 443-458, 2006.

Schmidt BJ.  Early delayed ascending myelopathy after low spine injury: Case report and evidence of a vascular mechanism.  Spinal Cord 44: 322-325, 2006.

Cowley KC, Zaporozhets E, MacLean JN, and Schmidt BJ.  Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord?   J. Neurophysiol. 94: 3805-3814 2005.

Lambert D, Giannouli E, and Schmidt BJ.  Post-polio syndrome and anesthesia.  Anesthesiology 103: 638-644, 2005.

Zaporozhets E, Cowley KC, and Schmidt BJ.  A reliable technique for the induction of  locomotor-like activity in the in vitro neonatal rat spinal cord using brainstem electrical stimulation.   J.  Neurosci. Methods  39: 33-41, 2004.

Schmidt BJ, Greenberg CR, Allingham-Hawkins DJ, and Spriggs EL.  Expression of X-linked bulbospinal muscular atrophy (Kennedy Disease) in two homozygous females.  Neurology  59: 770-772, 2002.

Jordan LM and Schmidt BJ.  Propriospinal neurons involved in the control of locomotion: Potential targets for repair strategies? In: Spinal Cord Trauma: Neural Repair and Functional Recovery. L. McKerracher, Rossignol, S, and Doucet, G (eds), Progress in Brain Research, Elsevier, NY. 137: 125-140, 2002.

Schmidt BJ and Jordan LM.  The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord.  Brain Res. Bull. 53: 689-710, 2001.

MacLean J. and Schmidt B.J.   Voltage-sensitivity of motoneuron NMDA receptor channels is modulated by serotonin in the neonatal rat spinal cord.   J. Neurophysiol.  86: 1131-1138, 2001

MacLean J. Cowley KC and Schmidt BJ.  Serotonin modulates NMDA receptor-mediated intrinsic voltage oscillations in neonatal rat lumbar motoneurons. J. Neurophysiol. 79: 2804-2808, 1998.

Hochman S and Schmidt BJ.  Whole-cell recordings of locomotor-like activity in motoneurons in the in vitro neonatal rat spinal cord.  J. Neurophysiol. 79: 743-752, 1998.

MacLean J, Schmidt BJ, and Hochman S.  NMDA receptor activation triggers voltage oscillations, plateau potentials and bursting in neonatal rat motoneurons in vitro. Eur. J. Neurosci.  9: 2702-2711, 1997.

Cowley KC and Schmidt BJ.  Regional distribution of the locomotor pattern generating  network in the neonatal rat spinal cord.  J. Neurophysiol. 77:247-259, 1997.

Cowley KC, and Schmidt BJ. Effects of inhibitory amino acid antagonists on reciprocal inhibitory interactions during rhythmic motor activity in the in vitro neonatal rat spinal cord.  J. Neurophysiol.  74: 1109-1117, 1995.

Lei Song, Schmidt BJ, and Shefchyk SJ.  Pelvic and pudendal reflexes in the in vitro neonatal rat preparation.  Brain Res. 675: 165-170, 1995.

Nance P, Schryvers O, Schmidt B, Dubo H, Loveridge B, Fewer D.  Intrathecal baclofen treatment for adults with spasticity: Therapeutic efficacy and effect on hospital admissions. Can. J. Neurol. Sci.  22: 22-29, 1995.

Hochman S, Jordan LM, and Schmidt BJ.  TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons.  J. Neurophysiol. 72: 2559-2562, 1994.

Schmidt BJ. Afterhyperpolarization modulation in lumbar motoneurons during locomotor-like rhythmic activity in the rat spinal cord in vitro.  Exp Brain Res 99:214-222, 1994.

Cowley KC and Schmidt BJ.  A comparison of motor patterns induced by N-methyl-D-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord.  Neurosci Letts 171: 147-150, 1994.

Cowley KC and Schmidt BJ.  Some limitations of ventral root recordings for the monitoring locomotion in the in vitro neonatal rat spinal cord preparation.  Neurosci Letts 171: 142-146, 1994.



Dr. Brian Schmidt