Education and Training
Licensure and Certification
Selected Hospital and Academic Appointments
Gotes, J, Jacobs, Kasian K, Cheng ZQ, Mink SN. Benefits of ethyl gallate vs norepinephrine in the treatment cardiovascular collapse in Pseudomonas aeruginosa septic shock in dogs. In Press, Critical Care Medicine.
Mink SN, Jacobs H, Cheng ZQ, Kasian K, Santos-Martinez LE, Light RB. Lysozyme, a mediator of sepsis that intrinsically generates hydrogen peroxide to cause cardiovascular collapse. Am J Physiol Heart and Circ Physiol 297: H930-H938, 2009.
Mink SN, Kasian, K, Santos-Martinez LE, Bose R, Cheng ZQ, Jacobs H, Bose R, Jacobs J, Light RB. Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation. Am J Physiol Heart and Circ Physiol 294: H1724-H1735, 2008.
Buduhan G, Tan, Kasian K, Mink SN. Volume reduction surgery impairs immediate post-operative pulmonary function in canine emphysema. Am J Respir Crit Care Med 174:1310-1318, 2006.
Mink SN, Bose R, Roberts DE, Jacobs H, Duke K, Bose D, Cheng ZQ, Light RB. Lysozyme binding to endocardial endothelium mediates myocardial depression by the nitric-oxide guanosine 3’,5’ monophosphate pathway in sepsis. J Mol Cell Cardiol 2005; 39: 615-625.
Jacobs H, Mink SN, Duke K, Bose D, Cheng ZQ, Howlett S, Ferrier G, Light RB. Characterization of surface membrane N-glycan binding sites of lysozyme for myocardial depression in sepsis. Intensive Care Medicine 2005; 31:129-137.
Mink SN, Gonzalez X, Duke K, Bautista E, Tan L. Advantages of a new surgical system used for lung volume reduction surgery in a canine model of predominantly upper lobe emphysema. Chest 2004; 125:633-643.
Mink SN, Jacobs H, Bose D, Duke, Cheng Z, Light RB. N,N’,N” triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in E coli sepsis in dogs. Crit Care Med 2004; 32:184-193.
Mink SN, Jacobs H, Bose D, Duke K, Cheng Z, Liu G, Light RB. Lysozyme: a mediator of myocardial depression and adenergic dysfunction in septic shock in dogs. J Mol Cell Cardiol 35: 265-275,2003.
Eschun G, SN Mink, Sat Sharma. Pulmonary interstitial fibrosis as a presenting manifestation in p-ANCA microscopic polyangiitis. Chest 123: 297-301, 2003.
Chrusch C, Bautista E, Jacobs HJ, Bose D, Duke K, Mink SN. Effect of pH on organ distribution of lactate metabolism in canine sepsis. J Crit Care 17: 188-202, 2002.
Ewing-Bui, DT, SN Mink. Interdependence of flow between lobes reduces maximal emptying post-resection in dogs. J Appl Physiol. 92: 1008, 2002.
Eschun G, E Bautista, K Duke, SN Mink. Effect of histamine H3 receptor blockade on venous return and splanchnic hemodynamics in sepsis. Critical Care Medicine 30:628-636, 2002.
Cheng Z, Bose D, Jacobs H, Light RB, Mink SN. Sepsis causes presynaptic histamine H3 and alpha2 adrenergic dysfunction in canine myocardium. Cardiovascular Research 56: 225-34, 2002.
Chrusch, C, S Sharma, H Unruh, E Bautista, K Duke, A Becker, W Kepron, SN Mink. Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis. Am J Respir Critical Care Medicine 160: 1142-1149, 2000.
Chrusch, C, Bands C, Bose D, Li X, Jacobs H, Duke K, Bautista E, Light RB, Mink SN. Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. Am J Respir Crit Care Med 161:517-526, 2000.
Patel D, K Duke, RB Light, H Jacobs, SN Mink, D Bose. Impaired sarcoplasmic calcium release inhibits myocardial contraction in experimental sepsis. J Critical Care 15: 64-72, 2000.
Mink S, Sharma S, Becker A, Duke K, Unruh H, Kepron W. Role of autocoids in cardiovascular collapse in anaphylactic shock in dogs. Cardiovascular Research 43: 173-182, 1999.
Mink S, X Li, D Bose, M Gu, G Lu, H Jacobs, RB Light. Early but not delayed continuous arteriovenous hemofiltration improves cardiac function in sepsis in dogs. Intensive Care Medicine 25:733-743, 1999.
Mink SN, A Becker, H Unruh, W Kepron. Effects of mediators of anaphylaxis on partitioned pulmonary vascular resistance during ragweed shock in dogs. J Appl Physiol 84: 782-790, 1998.
Mink SN, C Bands, A. Becker, J Elkin, S. Sharma, H. Unruh, W. Kepron. Effect of bolus epinephrine on systemic hemodynamics in canine anaphylactic shock. Cardiovascular Research 40:546-556, 1998.
Li, X, G Eschun, D Bose, H Jacobs, JJ Yang, RB Light, SN Mink. Histamine H3 activation depresses cardiac function in experimental sepsis. J Appl Physiol 85(5):1693-1701, 1998.
Mink S. Mechanism of lobar alveolar pressure decline during forced expiration in canine regional emphysema. J Appl Physiol. 82: 632-643, 1997.
Yu J, Mink S. Activation of pulmonary rapidly adapting receptors does not induce bronchoconstriction in dogs. J. Appl. Physiol. 80: 233-239, 1996.
Mink S, Jha P, Wang R, Yang J, Bose D, Jacobs H, Light R. Effect of arteriovenous hemofiltration combined with systemic vasopressor therapy on depressed left ventricular contractility and oxygen delivery in canine E. coli sepsis. Anesthesiology 83: 178-190, 1995.
Gomez A, Unruh H, Mink S. Left ventricular systolic function is depressed in chronic pulmonary emphysema in dogs. Am J Physiol 267 (Heart Circ Physiol 36): H232-H247, 1994.
Georgopoulos D, Gomez A, S Mink. Factors determining lobar emptying rates during maximal and partial forced deflations in nonhomogeneous airway obstruction in dogs. Am J Respir and Crit Care Med 149: 1241-1247, 1994.
Jha P, Jacobs H, Bose D, Wang R, Yang J, Light RB, Mink S. Effects of E. coli sepsis and myocardial depressant factor on interval-force relations in dog ventricle. Am J Physiol 264 (Heart Circ Physiol 33): H1402-H1410, 1993.
Gomez A, Unruh H, Mink S. Altered left ventricular chamber stiffness and isovolumic relaxation in dogs with chronic pulmonary hypertension caused by emphysema. Circulation 87: 247-260, 1993.
Gomez A, Mink S. Interaction between effects of hypoxia and hypercapnia on altering left ventricular relaxation and chamber stiffness in dogs. Am. Rev. Respir. Dis. 146: 313-320, 1992.
Gomez A, Wang R, Unruh H, Light RB, Bose D, Chau T, Correa E, Mink SN. Hemofiltration reverses left ventricular dysfunction during sepsis in dogs. Anesthesiology 73:671-685, 1990.
Gomez A, Eng J, Mink SN. Aminophylline has little positive inotropic effect and a slightly negative diastolic effect on the left ventricle during hypoxic conditions in dogs. Am. Rev. Respir. Dis. 137:1296-1303, 1988.
Gomez A, Mink SN. Increased left ventricular stiffness impairs filling in dogs with pulmonary emphysema in respiratory failure. J. Clin. Invest.78:228-240, 1986.
Jadue C, Greville HW, Coalson JJ, Mink SN. Forced expiration and HeO2 response in canine peripheral airways obstruction. J. Appl. Physiol.58(6):1788-1801, 1985.
Pysczynski D, Mink SN, Anthonisen NR. Increased gravitational stress does not alter maximum expiratory flow. J. Appl. Physiol., 59(1):28-33, 1985.
Mink SN, Unruh H, Oppenheimer L. Vascular and interstitial mechanics in canine pulmonary emphysema. J. Appl. Physiol.59:1704-1715, 1985.
Mink SN. Expiratory flow limitation and the response to breathing a helium-oxygen gas mixture in a canine model of pulmonary emphysema. J. Clin. Invest.73:1321-1334, 1984.
Mink SN, Coalson JJ, Whitley L, Greville H, Jadue C. Pulmonary function tests in the detection of small airway obstruction in a canine model of bronchiolitis obliterans. Am. Rev. Respir. Dis.130:1125-1133, 1984.
Mink SN. Mechanism of reduced maximum expiratory flow in methacholine-induced bronchoconstriction in dogs. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 55:897-912, 1983.
Light RB, Mink SN, Wood LDH. The effect of unilateral PEEP on gas exchange and pulmonary function in canine lobar pneumonia. Anesthesiology 55(3):251-255, 1981.
Mink SN, Wood LDH. How does HeO2 increase maximum expiratory flow in human lung? J. Clin. Invest.66:720-729, 1980.