University of Manitoba - Medicine - Immunology

Take a look back at our
50th Anniversary Celebration

ANNOUNCING OUR NEW DEPT. HEAD
DR. AARON MARSHALL

Department Events 2018-2019

EVENT SCHEDULE
September	October	November	December	January	February
March	April	May	June	July	August

EVENTS, TIMES AND LOCATIONS
All events take place in the Department of Immunology, A. Sehon Suite, 477 Apotex Centre, 750 McDermot Ave, unless otherwise noted.
Journal Club (Instructions to students)	Mondays, 11:00 a.m. - 12:15 p.m.
Research Seminars Graduate Student Research Seminars Research in Progress	Thursdays, 12:00 - 1:15 p.m.
All other events	as scheduled below

SEPTEMBER
13	Biosafety seminar Dr. Thomas Murooka Department of Immunology This seminar is COMPULSORY for all Immunology students, and lab personnel including Research Associates, Post Docs, technicians, students, visiting students and volunteers.
17	Welcome Back and Award ceremonies Starts at 1:00 p.m.
20	Research Seminar Dr. Pradip Maiti President & Chief Scientific Officer Immunimed Inc. Professional Affiliate, Department of Immunology *Development of polyclonal antibody therapeutics for treatment and prevention of enteric diseases including clostridium difficile-associated infection*
24	No Journal Club
27	Research Seminar No seminar today
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OCTOBER
1	Journal Club TBD
4	Research Seminar - cancelled Child Health Research Days
8	Thanksgiving - University Closed
11	Research Seminar Dr. Xiangguo Qiu Special Pathogens Program National Microbiology Laboratory Post ZMapp-new developments on immunotherapy against Ebola viruses
15	Journal Club Alen Paiva Article: Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. DOI: 10.1016/j.immuni.2018.03.012 PMID: 29625893
18	Research Seminar Dr. Richard Keijzer Department of Surgery Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba *MiRacles for babies with abnormal lung development*
19 NB: FRIDAY 8:30 a.m.	Semaphorin3E Symposium Dr. Jonathan Duke-Cohan Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School *Trafficking in the thymus: new insights into the origins of autoimmunity*
22	Journal Club Anthony Altieri F. Filipello, R. Morini, I. Corradini, V. Zerbi, A. Canzi, B. Michalski, M. Erreni, M. Markicevic, C. Starvaggi-Cucuzza, K. Otero, L. Piccio, F. Cignarella, F. Perrucci, M. Tamborini, M. Genua, L. Rajendran, E. Menna, S.Vetrano, M. Matteoli. The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity. *Immunity.* Volume 48, Issue 5, 15 May 2018, Pages 979-991.e8
25	Research Seminar No seminar today
26 FRIDAY	M.Sc. Thesis Defence Kunal Kapoor *Anti-inflammatory role of chromofungin, a chromogranin a-derived peptide, in the context of colitis* 9:00-10:30 a.m. Alec Sehon Seminar Room 477 Apotex Centre
29	Journal Club Vasudeva Bhat Adair L. Borges, Jenny Y. Zhang, MaryClare F. Rollins, Beatriz A. Osuna, Blake Wiedenheft and Joseph Bondy-Denomy. Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity. *Cell 174, 917-925.* August 9, 2018. https://doi.org/10.1016/j.cell.2018.06.013
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NOVEMBER
1	Research Seminar Dr. Versha Banerji Department of Internal Medicine Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba & Manitoba Institute of Cell Biology *Using real world clinical data: From clinical care to translational research*
5	Journal Club Rony Thomas S. Tsai, X. Clemente-Casares, A.C. Zhou, H. Lei, J.J. Ahn, Y. T. Chan, O. Choi, H. Luck, M. Woo, S. E. Dunn, E.G. Engleman, T.H. Watts, S. Winer, and D.A. Winer. Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection. Cell Metabolism, 2018 Aug 22. pii: S1550-4131(18)30504-7. https://doi.org/10.1016/j.cmet.2018.08.003
8	Research Seminar Dr. Keith Fowke Department of Medical Microbiology Rady Faculty of Health Sciences University of Manitoba *Does sex work drive immune tolerance?* Some female sex workers in Nairobi are highly exposed to HIV yet remain uninfected. Immune activation is higher in HIV infection and activated CD4+ T cells are preferred targets for HIV infection. Our lab has shown that the longer a women has been involved in sex work the lower her immune activation levels are. Is sex work driving this lower level of immune activation and possibly contributing to increased resistance to HIV infection?
FRIDAY Nov. 9	RESEARCH WORKSHOP Lentiviral Vector Viral Particles Production Core Platform 12:00 - 1:00 p.m. Alec Sehon Seminar Room 477 Apotex Centre (4th floor)
12	Remembrance Day - University Closed
15	Research Seminar Dr. Janilyn Arsenio Manitoba Centre of Proteomics and Systems Biology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba Understanding CD8+ T cell differentiation at the single-cell level
19 NB: STARTS AT 11:30 a.m. TODAY	Journal Club Hadeesha Piyadasa Keren L, Bosse M, Marquez D, Angoshtari R, Jain S, Varma S, Yang SR, Kurian A, Van Valen D, West R, Bendall SC, Angelo M. A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging. Cell. 2018 Sep 6;174(6):1373-1387.e19. doi: 10.1016/j.cell.2018.08.039. https://www.ncbi.nlm.nih.gov/pubmed/30193111
22	Research Seminar Caroline Graham Research Associate, HayGlass Lab Department of Immunology What to expect when you are expecting: If and how your innate immune system changes during a healthy successful human pregnancy LOCATION: 500 John Buhler Research Centre
26	Journal Club Folayemi Olayinka-Adefemi L.A. O’Reilly, T.L. Putoczki, L.A. Mielke, J.T. Low, A. Lin, A. Preaudet, M.J. Herold, K. Yaprianto, L. Tai, A. Kueh, G. Pacini, R. L.Ferrero, R. Gugasyan, Y. Hu, M. Christie, S. Wilcox, R. Grumont, M. D.W. Griffin, L. O’Connor, G.K. Smyth, M. Ernst, P. Waring, S. Gerondakis, A. Strasser. Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner. *Immunity* Volume 48, Issue 3, 20 March 2018, Pages 570-583.e8
29	Special Seminar A Special Seminar, for Dept of Immunology Graduate Students only, will be offered as follows: Ms. Kate Yee Career Consultant Student Affairs Career Services University of Manitoba The Immunology Student Council has invited Ms. Yee to give a presentation covering the following: Future of immunologists Academia vs industry C.V. vs. resume When, where and how to apply for different positions
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DECEMBER
3	Journal Club Aaron Chanas-LaRue Zhutian Zeng, Bas G. J. Surewaard, Connie H. Y. Wong, Christopher Guettler, Björn Petri, Regula Burkhard, Madeleine Wyss, Hervé Le Moual, Rebekah Devinney, Graham C. Thompson, Jaime Blackwood, Ari R. Joffe, Kathy D. McCoy, Craig N. Jenne, and Paul Kubes. Sex-hormone-driven innate antibodies protect females and infants against EPEC infection. Nature Immunology. volume 19, pages1100–1111 (2018).
6	Research Seminar Dr. Jason Kindrachuk Canada Research Chair in the molecular pathogenesis of emerging and re-emerging viruses Department of Medical Microbiology & Infectious Diseases Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba Characterizing the molecular determinants underlying severe Ebola virus disease and post-recovery persistence: science under negative pressure
10	Journal Club Joaquin Ernesto Fajarde Despaigne Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol. 2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7
13	Research Seminar Dr. Sabine Hombach-Klonisch Human Anatomy and Cell Science Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba The oncofetal HMGA2 protects the cancer cell genome
17	Journal Club Nnamdi Ikeogu A. Glasner, A. Levi, J. Enk, B. Isaacson, S. Viukov, S. Orlanski, A. Scope, T. Neuman, C.D. Enk, J.H. Hanna, V. Sexl, S. Jonjic, B. Seliger, L. Zitvogel, O. Mandelboim. NKp46 Receptor-Mediated Interferon-g Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity 48, 107–119 January 16, 2018. https://doi.org/10.1016/j.immuni.2017.12.007
20	Research Seminar - Cancelled
	*University Closed December 22, 2018 to January 2, 2019 inclusive*
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JANUARY
10	Golden Anniversary Research Seminar Series Dr. Kent HayGlass Department of Immunology Your sex shapes innate immunity: Women and Men Differ, Boys and Girls not so much
14	Journal Club Rahmat Rahman C.S. Garris, S.P. Arlauckas, R.H. Kohler, M.P. Trefny, S. Garren, C. Piot, C. Engblom, C. Pfirschke, M. Siwicki, J. Gungabeesoon, G.J. Freeman, S.E. Warren, S. Ong, E. Browning, C.G. Twitty, R.H. Pierce, M.H. Le, A.P. Algazi, A.I. Daud, S.I. Pai, A. Zippelius, R. Weissleder, and M.J. Pittet Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. Volume 49, Issue 6, P1148-1161.e7, December 18, 2018 https://www.cell.com/immunity/fulltext/S1074-7613(18)30439-4
17	Annual Graduate Student Research Seminar Vasudeva Bhat *Identification and characterization of a new basal-like luminal progenitor in human breast tissue*
21	Journal Club No Journal Club today
24	Annual Graduate Student Research Seminar Hadeesha Piyadasa TBD Rony Thomas *Semaphorin 3E in host defense against chlamydial infection*
28	Journal Club Abdoulaye Diarra M.G. Pauthner, J.P. Nkolola, C. Havenar-Daughton, B. Murrell, S.M. Reiss, R. Bastidas, J. Prevost, R. Nedellec, B. von Bredow, P. Abbink, C.A. Cottrell, D.W. Kulp, T. Tokatlian, B. Nogal, M. Bianchi, H. Li, J. Hyun Lee, S.T. Butera, D.T. Evans, L. Hangartner, A. Finzi, I.A. Wilson, R.T. Wyatt, D.J. Irvine, W.R. Schief, A.B. Ward, R.W. Sanders, S. Crotty, G.M. Shaw, D.H. Barouch, and D.R. Burton. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity. 2019 Jan 15;50(1):241-252. https://doi.org/10.1016/j.immuni.2018.11.011
30	M.Sc. Thesis Defence Rahmat Rahman JNK-associated leucine zipper (JLP) scaffolding protein regulates natural killer cell migrations 9:30-11:30 a.m. Alec Sehon Seminar Room (477 Apotex Centre)
31	Annual Graduate Student Research Seminar Rashed Rashu Lung resident memory T cells in chlamydia infection
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FEBRUARY
4	Journal Club Ashley Ste-Croix Ellen C. Moore, Lillian Sun, Paul E. Clavijo, Jay Friedman, Joe B. Harford, Anthony D. Saleh, Carter Van Waes, Esther H. Chang & Clint T. Allen. Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STINGdependent mechanisms Oncoimmunology 2018, Vol. 7, No. 7, e1404216 https://doi.org/10.1080/2162402X.2017.1404216
7	Annual Graduate Student Research Seminar No seminar today
11	Journal Club Gloria Akaluka K. Hirota, M. Hashimoto, Y. Ito, M. Matsuura, H. Ito, M. Tanaka, H. Watanabe, G. Kondoh, A. Tanaka, K. Yasuda, M. Kopf, A.J. Potocnik, B. Stockinger, N. Sakaguchi, and S. Sakaguchi. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. 2018, Immunity 48, 1220–1232. https://doi.org/10.1016/j.immuni.2018.04.009
14	Golden Anniversary Research Seminar Series Dr. Jude Uzonna Changing dogma? Immunologic memory may need constant reminders
18	Louis Riel Day - University Closed
21	Annual Graduate Student Research Seminar Alen Paiva Identification and characterization of immune cells in tumour-adjacent breast tissue Nnamdi Ikeogu Regulation of host's immunity to cutaneous leishmaniasis by Semaphorin 3E
25	Journal Club Xun Wu B.M. Szczerba, F. Castro-Giner, M. Vetter, I. Krol, S. Gkountela, J. Landin, M.C. Scheidmann, C. Donato, R. Scherrer, J. Singer, C. Beisel, C. Kurzeder, V. Heinzelmann-Schwarz, C. Rochlitz, W.P. Weber, N. Beerenwinkel & N. Aceto. Neutrophils escort circulating tumour cells to enable cell cycle progression. Nature 2019. https://www.nature.com/articles/s41586-019-0915-y
25	Edge of Science in Medicine Dr. Andrew P. Makrigiannis Professor and Head Department of Microbiology and Immunology Dalhousie University *The Case of Mike's missing macrophages: Role of 'NK Cell receptor' in alveolar macrophage development and function* 12:00 noon Frederic Gaspard Theatre Basic Medical Sciences Building
26	PUBLIC PRESENTATION HEADSHIP CANDIDATE Dr. Aaron Marshall Professor, Department of Immunology Noon - 1:00 p.m. Theatre C, Basic Medical Sciences Bldg.
28	Annual Graduate Student Research Seminar TBD
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MARCH
4	Journal Club No Journal Club
7
11	Journal Club Dina Mostafa T. Sumida, M.R. Lincoln, C.M. Ukeje1, D.M. Rodriguez, H. Akazawa, T. Noda, A.T. Naito, I. Komuro, M. Dominguez-Villar and D.A. Hafler. Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology. Vol 19, December 2018 pgs. 1391–1402. https://doi.org/10.1038/s41590-018-0236-6
13	Ph.D. Thesis Defence Vasudeva Bhat NOTCH3-FRIZZLED7 signaling regulates luminal cell fate in human breast tissue 9:30 - 11: 30 a.m. Alec Sehon Seminar Room, 477 Apotex Centre
13
14	Annual Graduate Student Research Seminar Amena Aktar PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma
18	Journal Club Mahder Teffera Banks, D. A., Ahlbrand, S. E., Hughitt, K. V., Shah, S., Mayer-Barber, K. D., Vogel, S. N., et al. (2019). Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival. The Journal of Immunology. http://www.jimmunol.org/content/early/2019/03/01/jimmunol.1801303
21	Annual Graduate Student Research Seminar Ernesto Fajardo Despaigne *Role of follicular helper T cell subsets in chronic lymphocytic leukemia* Abdoulaye Diarra Chromofungin ameliorates colitis and reduces endoplasmic reticulum stress/P53-apoptotic pathways
25	Journal Club Roma Zayats M. Kanekiyo, M.G. Joyce, R.A. Gillespie, J.R. Gallagher, S.F. Andrews, H.M. Yassine, A.K. Wheatley, B.E. Fisher, D.R. Ambrozak, A. Creanga, K. Leung, E.S.Yang, S. Boyoglu-Barnum, I.S. Georgiev, Y. Tsybovsky, M.S. Prabhakaran, H. Andersen, W. Kong, U. Baxa, K. L. Zephir, J.E. Ledgerwood, R.A. Koup, P.D. Kwong, A.K. Harris, A. B. McDermott, J.R. Mascola & B.S. Graham. *Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nature Immunology* vol. 20, pp 362–372 (2019). https://www.nature.com/articles/s41590-018-0305-x
28	Annual Graduate Student Research Seminar Mahder Teffera *Capripoxvirus Studies: Characterization of different strains and development of DIVA and other recombinant Vaccines* Gloria Akaluka *Regulation of Inflammasome and NET formation in Neutrophils by PI3K*
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APRIL
1	Journal Club Amena Aktar B.C. Miller, D.R. Sen, R. Al Abosy, K. Bi, Y.V. Virkud, M.W. LaFleur, K.B. Yates, A. Lako, K. Felt, G.S. Naik, M. Manos, E. Gjini, J.R. Kuchroo, J.J. Ishizuka, J.L. Collier, G.K. Griffin, S.Maleri, D.E. Comstock, S.A. Weiss, F.D. Brown, A. Panda, M.D. Zimmer, R.T. Manguso, F.S. Hodi, S.J. Rodig, A.H. Sharpe and W.N. Haining. Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. Nature Immunology. volume 20, pages 326–336 (2019). https://doi.org/10.1038/s41590-019-0312-6.
4	Research Seminar Dr. Lisa Reynolds University of Victoria Department of Biochemistry and Microbiology *Modulation of host immunity by gut-dwelling helminths and bacterial microbes*
8 11:00 a.m.
11	Annual Graduate Student Research Seminar Aida Barazandeh The critical role of phosphoenolpyrovate carboxykinse (PEPCK) in pathogenesis of cutaneous leishmaniasis Aaron Chanas-Larue *H1 antihistamines induce synergistic cell death in CLL cells when combined with ibrutinib in vitro*
15	Journal Club Atta Yazdanpanah A. De Luca, M. Pariano, B. Cellini, C. Costantini, V. R. Villella, S.S. Jose, M. Palmieri, M. Borghi, C. Galosi, G. Paolicelli, L. Maiuri, J. Fric, T. Zelante. The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways. Cell Reports 20, 1667–1680, August 15, 2017. http://dx.doi.org/10.1016/j.celrep.2017.07.063
18	Annual Graduate Student Research Seminar Ashley Ste-Croix *INPP4’s Role in the Regulation of BCR Signaling and Metabolic Activity* Xun Wu *Abnormal T follicular helper cell subsets in Chronic Lymphocytic Leukemia*
22	Journal Club Aida Barazandeh F. Zhang,R. Li, Y. Yang, C. Shi, Y. Shen, C. Lu, Y. Chen, W. Zhou, A. Lin, L. Yu, W. Zhang, Z. Xue, J. Wang, and Z. Cai. Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses. Immunity https://doi.org/10.1016/j.immuni.2019.01.010
25	Annual Graduate Student Research Seminar Anthony Altieri *Regulation of airway inflammation: IL-17 & TNF* Dina Mostafa *Sex-related differences in a house dust mite-challenged murine model of allergic asthma*
29	Journal Club Abdulaziz Alamri L.C. Burzynski, M. Humphry, K. Pyrillou, K.A. Wiggins, J.N.E. Chan, N. Figg, L.L. Kitt, C. Summers, K.C. Tatham, P.B. Martin, M.R. Bennett, and M.C.H. Clarke. The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1a by Thrombin. Immunity. 50, 1–10 April 16, 2019.
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MAY
1	Special Seminar Presentation by Student Counselling Office *Managing Stress in a Demanding Program: Strategies, Resources, and Support* 12 noon Alec Sehon Seminar Room
2	Annual Graduate Student Research Seminar Fola Olayinka-Adefemi *The function of P13K Delta (P110d) enzyme in protective immunity to trypanosoma congolense* Atta Yazdanpanah *Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo and HIV susceptibility*
6	Golden Anniversary Research Seminar Series Dr. Andrew Halayko Oxidized phosphatidylcholines in asthma pathophysiology: A clue for new Therapies?
9	Research Seminar Dr. Edwin Wang AIHS Translational Chair in Cancer Genomics/Informatics Cumming School of Medicine University of Calgary *Tumor single-cell and genomics suggest that germline functional variants in NK cells are associated with survival and immunotherapy*
13	Journal Club Rashed Rashu Shi J, Hou S, Fang Q, Liu X, Liu X, Qi H. PD-1 Controls Follicular T Helper Cell Positioning and Function. Immunity. 2018 Aug 21;49(2):264-274.e4. doi: 10.1016/j.immuni.2018.06.012. Epub 2018 Jul 31. https://www.ncbi.nlm.nih.gov/pubmed/30076099
15	M.Sc. Thesis Defence Atta Yazdanpaneh Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo and HIV susceptibility 10:00 a.m. Alec Sehon Seminar Suite 477 Apotex Centre
16	Annual Graduate Student Research Seminar Abdulaziz Alamri Roma Zayats Cellular dynamics of immune evasion during Leishmania major infection
20	Victoria Day - University Closed
23	Research Seminar Dr. Natacha Colliou Research Associate Department of Immunology Development of new strategies to prevent autoimmune and inflammatory diseases
30	No Research Seminar Today
JUNE
6	2018/2019 Distinguished Immunologist Lecture POSTPONED UNTIL FALL 2019 Dr. Paul Kubes University of Calgary Departments of Physiology & Pharmacology Medicine & Microbiology, Immunology & Infectious Diseases Director, Snyder Institute of Infection, Immunity and Inflammation
20	Golden Anniversary Research Seminar Series Dr. Kelly MacDonald Testing herpesvirus vectors in the real world African setting: lessons learned to guide vaccine trials
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JULY
25	M.Sc. Thesis Defence Aaron Chanas-Larue *Antihistamines induce synergistic cell death when combined with ibrutinib in malignant B cell lines and primary chronic lymphocytic leukemia cells* 10:00-11:30 a.m. Sehon Seminar Room, 477 Apotex Centre
AUGUST
21	M.Sc. Thesis Defence Folayemi Olayinka-Adefemi *The function of phosphatidylinositol 3-kinase delta (PI3Kδ) enzyme in protective immunity to Trypanosoma congolense infection in mice: Role of regulatory B cells* 9:00-11:00 a.m. Sehon Seminar Room, 477 Apotex Centre and M.Sc. Thesis Defence Nnamdi Ikeogu Regulation of immunity to cutaneous leishmaniasis by semaphorin 3E 12:00 noon - 2:00 p.m. Sehon Seminar Room, 477 Apotex Centre
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Department Events 2017/2018

Department Events 2019/2020