|Course Co-ordinator:||Dr. Jude Uzonna|
|Office:||425 Apotex Centre|
|Course Times:||Tuesdays and Thursdays 9:30 - 11:30 a.m.
January 9 - May 15, 2018
|Location:||477 Apotex Centre, A. Sehon Seminar Room|
To develop an in-depth understanding of the development, functioning and regulation of the mammalian immune system. This is the most advanced course in the Department of Immunology and is aimed at senior graduate students in immunology or those in related disciplines who wish an advanced perspective on immunologic knowledge and current research.
IMMU7070 - Introductory Immunology (or equivalent) or the written permission of the course Co-ordinator. Course instructors will assume that students are familiar with immunology at the level of the Abbas textbook Basic Immunology, 2012.
Intensive. Lectures (2 hr/lecture) will be held twice a week (Tuesdays and Thursdays 9:30-11:30 a.m.) in room 477, the Alec Sehon Seminar Room, in the Apotex Centre building. At the discretion of the instructors, lectures may be didactic and/or paper-based discussions.
This course will be graded based on a midterm (35% of the final mark), 1 take-home assignment (10%), participation in a formal "in class" debate on a topic to be assigned (10%) and a final exam mostly on the lectures given after the midterm (45%). Please note that the final exam will also include about 2 questions from lectures given prior to the midterm exam. The take-home assignment, which will be given at the end of lectures, will test students' critical thinking, analytical and synthesis abilities and will require students to design experiments (including appropriate controls) to test immunological hypotheses. Both the mid-term and final exam questions will be of the short answer style and will test students' critical thinking and analytical skills.
|Midterm Exam (closed book)||35%|
|Final Exam (closed book)||45%|
|Take home assignment||10%|
|Jan. 9, 2018||Course Overview: Brief Review of Immunology||J. Uzonna|
|Jan. 11||Dendritic Cell Biology||S. Kung|
|Jan. 16||NK Cell Biology||S. Kung|
|Jan. 18||Haematopoesis and Immunity||A. Raouf|
|Jan. 23||Pattern Recognition Receptors and Host Defense Peptides||N. Mookherjee|
|Jan. 25||Granuloctye: Ontogeny and Function||A. Soussi Gounni|
|Jan. 30||Antigen Presentation: Cytotoxicity and Anti-viral Immunity||S. Babiuk|
|Feb. 1||Antigen Receptor Structure, Diversity and Recognition||A. Marshall|
|Feb. 6||B Cell Biology||A. Marshall|
|Feb. 8||Signaling Through Immune System Receptors||A. Marshall|
|Feb. 13||Chemotaxis and Homing of Immune Cells||F. Lin|
|Feb. 15||Immunologic Memory||J. Uzonna|
|Feb. 20||Regulation of Immune Responses, Costimulation, Cytokines, Th1/Th2||K. HayGlass|
|Feb. 22||No class (Study Week)|
|Feb. 27||No class (Study Week)|
|Mar. 1|| MID-TERM EXAM (closed book)
Location: Room 061Apotex Centre
Time: 9:00-11:30 a.m.
|Mar. 6||Cytokine and Chemokine Receptors: Structure, Signaling and Function||A. Soussi Gounni|
|Mar. 8||Vaccines/Extrinsic Regulation of Immune Responses||X. Yang|
|Mar. 13||Immunobiology of HIV/AIDS||L. Mckinnon|
|Mar. 15||Immunobiology of Transplantation||P. Nickerson|
|Mar. 20||Immunobiology of Hemorrhagic Viral Infections||G. Kobinger|
|Mar. 22||Apoptosis Pathways and Haematopoietic Cancers||S. Gibson|
|Mar. 29||Epigentic Regulation of Immune Response||R. Su|
|Apr. 5||Graft-versus-Host Disease and the Graft-versus-Malignancy Effect||TBD|
|Apr. 10||Animal Models of Studying the Immune System in vivo||T. Murooka|
|Apr. 12||Neuroimmunology||J. Ghia|
|Apr. 17||Viral Immunopathology and Vaccines||S. Babiuk|
|Apr. 19||Immunopathology||J. Uzonna|
|Apr. 26||Autoimmunity and Immune Deficiency States||C. Hitchon|
|May 1||The Mucosal Immune System||J. Ghia|
Rules of Engagement:
|May 8||DEBATES (continued)
Moderator: Rahmat Rahman
MOTION 4: All the innate lymphoid cell subsets identified to date represent basically the same single cell type.
Contributor: Dr. Sam Kung
For: Nnamdi Ikeogu
Against: Amena Aktar
MOTION 5: Hematopoietic stem cells are not part of the body's immune system.
Contributor: Dr. Afshin Raouf
For: Roma Zayats
Against: Alen Paiva
MOTION 6: Basic immunological research should expand the use of wild (feral) mice.
Contributor: Dr. Thomas Murooka
For: Aida Feiz Barazandeh
Against: Ashley Ste-Croix
FINAL EXAM (Closed book)
Time: 9:00 a.m. - 12 noon
|May 15||Take-home Assignment Due||J. Uzonna|