Example 2. Cerebral ischaemia
As with the myocardium, the brain is an excellent candidate for PET imaging using 18F-FDG. Figure 2 shows the distribution of 18F-FDG in a geriatric rat, with a clearly discernible region of low 18F-FDG uptake indicative of a perfusion defect.
Transverse plane Coronal plane
Example 3. Biodistribution of stem cells
PET imaging can also be used to study the biodistribution of cells introduced into an animal. Figure 3 shows PET images acquired over a 3 hour time period following tail vein injection of adipose derived stem cells previously incubated with 18F-FDG.
Figure 3. Biodistribution of labelled stem cells, as a function of time. Acquisition time: 3 hour dynamic study: Tracer: 18F-FDG labelled adipose tissue stem cells. Images acquired under a CIHR Emerging Team Grant in the Regenerative Medicine and Nanomedicine Initiative (P.I. Ganghong Tian, NRC-IBD).