His research interests focus on the use of high content methods for the analysis of biological and biomedical systems. He uses mass spectrometry extensively in conjunction with immunological and functional genomics methods for the development of analytical methods for discovery and validation in a range of clinical systems including renal function and rheumatic diseases. More recently he established the first Somalogic aptamer based system in Canada for the high content analysis of human specimens. In 2006 he was a co-recipient of the NSERC Brockhouse Prize for Interdisciplinary Research in Science and Engineering for Biomolecular Mass Spectrometry.
He reviews for many granting agencies including Canada Institutes for Health Research, Alberta Innovates Health Solutions, Nova Scotia Health Research, Fonds de recherche en santé du Quebec, The Michael Smith Foundation as well as several international agencies. He is a member of the College Reviewers for Canada Foundation for Innovation and Canada Research Chairs for over 10 years. He reviews for many journals including Proteomics, Nature Biotechnology, Analytical Chemistry, Analytical Chemistry and Biochemistry, Arthritis and Rheumatism, Journal of Immunology, and FEBS.
His goal is to see a wider uptake and integration of proteomic and mass spectrometry methods in basic and biomedical research. His basic research focus is on development of tools for assessing protein functional activity status with emphasis on the regulation of leukocyte movement. He also co-leads several applied grants for the application of methods such as activity based protein profiling, quantitative and discovery based mass spectrometry to a the study of a number of human conditions.