ARRHYTHMIA STUDIES: Local Investigator Initiated, Actively recruiting & Studies awaiting ethics/other approval (starting soon)


Local PI: Resident: C Lee Supervisor: C Seifer
Co-investigator: J Tam, WF McIntyre

Objective: The Frailty ICD/CRT study proposes to answer the question of whether frailty predicts outcomes in terms of mortality and morbidity in patients who receive ICD and/or CRT devices for the primary prevention of SCD.
Inclusion criteria:

- Patients whom are having an ICD placed for primary prevention of SCD
- Patients >/= 18 years of age who provide written informed consent
Recruitment: Ongoing


Local PI: Resident: WF McIntyre Supervisor : C Seifer
Co-investigators: J Tam, C Khoo

Objective: The hypotheses of the present study are that patients who received an ICD for primary prevention of SCD may experience a recovery in their systolic function and subsequently may:
1. Be at lower risk for sudden (arrhythmic) cardiac death, as approximated by the rate of appropriate ICD therapies;
2. Have other identifiable factors that predict their risk of appropriate device therapies in the second battery life

Inclusion criteria:

- Consecutive adult ICM and NICM patients at participating centres who originally received an ICD for primary prevention of SCD and are scheduled to undergo a pulse generator change at elective replacement indicator.
Recruitment: Ongoing
Results of a Physician Alert system for Anticoagulation of Atrial Fibrillation Detected on Cardiac Implanted Electronic Devices: A Follow Up Survey

Local PI: Resident: J Cloutier Supervisor : C Seifer
Co-investigator: C Khoo

Objective: We've previously reported the results of a physician alert system for anticoagulation of AF detected on a cardiac implantable electronic device (CIED), and found that nearly 60% of patients with AF detected on CIED were not anticoagulated, putting them at excess risk of stroke. Previous studies have shown that perceived risk of anticoagulation as well as physician inexperience with managing AF are associated with a lower rate of anticoagulation. We seek to delineate the reasons why these patients were not anticoagulated through a physician survey.

Recruitment: Ongoing (soon to be completed)

Studies awaiting ethics/other approval (starting soon)

Local PI: Residents: H Alfraidi/L Torbiak/WF McIntyre
Supervisor: C Seifer
Co-investigator: S Zieroth

Objective: In patients with systolic heart failure, QRS duration prolongation over time, may be a marker of worse clinical outcomes.

Inclusion criteria:
- Adult heart failure patients who are attending their first visit at a tertiary care heart failure outpatient clinic
- Patients should not have a ventricular paced rhythm

Study update: Completing the ethics documents with plans for submission in late 2015