Dr. Meaghan Jones
Assistant Professor, Department of Biochemistry and Medical Genetics
Member, UM Centre on Aging

Dr. Meaghan Jones received her BScH in Biology from Mount Allison University, and her PhD in Medical Genetics from the University of British Columbia. She pursued post-doctoral training at the University of British Columbia studying epigenetics of early life environments with Dr. Michael Kobor, before joining the Department of Biochemistry and Medical Genetics at the University of Manitoba in 2018. Dr. Jones’ current focus is the role of epigenetic changes in the link between mothers’ exposure to inhaled pollutants like cigarette smoke and their children’s risk of developing asthma. Students and staff in her lab have the opportunity to use large epigenetic data sets from human birth cohort studies to discover epigenetic changes associated with specific environmental exposures. These findings inform further experiments using model systems to understand the molecular and developmental impacts of prenatal exposures, leading to a truly multi-disciplinary learning experience.



The Jones lab research focuses on environmental exposures in the prenatal and early childhood periods, and seeks to establish when and how these become biologically embedded. This will be based on ongoing research using birth cohorts, which are not only immensely powerful in discovering associations with real-life exposures, but in many cases also have long term tracking and sampling. In order to translate these epigenetic findings in human populations to experimentally modifiable paradigms, the Jones lab also works with controlled exposure animal models to more fully understand the cellular and developmental consequences of the associations discovered in birth cohorts. Our long-term goal is to use cutting edge epigenetic tools in combination with well-developed birth cohorts and controlled exposures to investigate the mechanism and timing of biological embedding of specific environmental exposures on longterm health.

Dr. Jones is currently recruiting undergraduate and graduate students, post-docs, and a research technician.




Jones, MJ, Moore, SR, and Kobor, MS. (2018) Principles, Methodologies and Challenges of applying Epigenetic Epidemiology to Psychology. Annual Reviews of Psychology, 69:14.1–14.27.

Morin, AM, Gatev, E, McEwen, LM, MacIsaac, JL, Lin, DTS, Koen, N, Czamara, D, Raikkonen, K, Zar, HJ, Koenen, K, Stein, DJ, Kobor, MS, and Jones, MJ. (2017) Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs. Clinical Epigenetics, 9:75. 

Edgar, RD, Jones, MJ, Meaney, MJ, Turecki, G, Kobor, MS. (2017) BECon: A tool for interpreting DNA methylation findings from blood in the context of brain. Translational Psychiatry, 7, e1187. 

Clifford, RL, Jones, MJ, MacIsaac, JL, McEwen, LM, Goodman, SJ, Mostafavi, S, Kobor, MSK, and Carlsten, C. (2016) Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. Journal of Allergy and Clinical Immunology, 139(1):112-121. 

Esposito, E*, Jones, MJ*, Doom, J, MacIsaac, JL, Kobor, MS, Gunnar, M. (2016) Differential DNA Methylation of Peripheral Blood Mononuclear Cells in Adolescents Adopted as Young Children from Orphanages in Russia and Eastern Europe. Development and Psychopathology, 28:1385-1399.

Farré, P, Jones, MJ, Meaney, MJ, Emberly, E, Turecki, G, Kobor, MS. (2015) Concordant and Discordant DNA Methylation Signatures of Aging in Human Blood and Brain. Epigenetics and Chromatin, 8:19.

Jones, MJ, Goodman, SG, Kobor, MS. (2015) DNA methylation and healthy human aging. Aging Cell, 14(6):924-932.

Jones, MJ, Farré, P, McEwen, LM, MacIsaac, JL, Watt, K, Neumann, SM, Emberly, E, Cynader, MS, Virji-Babul, N, and Kobor, MS. (2013) Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome. BMC Medical Genomics, 6:58.


2016-ongoing
CIHR Team Grant: Developmental Origins of Health and Disease
Prenatal Programming of Children’s Mental Health: Epigenetic Mechanisms and Resilience Promotion

2016-ongoing
CIHR Team Grant: Environments, Genes and Chronic Disease
Programmatic research to understand how modifiable environmental factors interact with the genome in the development of asthma

2016-2018
NIH R21
Advancing the science and technology of prenatal programing research

2013-2015
CFRI Mining for Miracles Post-doctoral Fellowship
The role of acquired DNA methylation differences in the relationship between childhood stress and long-term health outcomes


Dr. Meaghan Jones, PhD
Area of Research: Epigenetics
Biosketch

University of Manitoba
745 Bannatyne Avenue, BMSB
Winnipeg, MB  R3E 0J9
Tel:
Fax:  204.789.3900
Lab Website
Meaghan.Jones@umanitoba.ca

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