Dr. Gilbert Arthur received his B.Sc. degree from the University of Ghana in Accra, Ghana, and his Ph.D. degree from the University of Leeds in England. He moved to Winnipeg to do his post-doctoral training with Dr. P. C. Choy at the University of Manitoba in the area of phospholipid metabolism in the heart with special emphasis on plasmalogens. Dr. Arthur is currently a Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba.
Developing Novel Anticancer Drugs
Dr. Arthur’s research focus is developing novel anticancer drugs via synthetic approaches or isolating novel compounds from plants. The goal is to develop new drugs that are effective against advanced and hard to treat cancers. We have successfully developed a number of synthetic compounds, glycosylated antitumor ether lipids, that are very effective against drug resistant cancer cells and cancer stem cells derived from a variety of human tumors. These compounds have the potential to prevent cancer recurrence and significantly prolong overall survival.
Dr. Arthur’s research program seeks to (a) develop more effective analogs of the existing compounds; (b) investigate their efficacy in animal models of human tumors and (c) investigate the mechanism of action of these compounds.
Samadder P, Xu Y, Schweizer F, Arthur G. Cytotoxic properties of D-gluco-, D-galacto- and D-manno-configured 2-amino-2-deoxy-glycerolipids against epithelial cancer cell lines and BT-474 breast cancer stem cells. Eur J Med Chem. 2014 May 6;78:225-35. PMID:24681987
Samadder P, Bittman R, Byun HS, Arthur G. A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death. Biochem Cell Biol. 2009 Apr;87(2):401-14. PMID:19370058
Lin W, Arthur G. Phospholipids are synthesized in the G2/M phase of the cell cycle. Int J Biochem Cell Biol. 2007;39(3):597-605. PMID:17113814
Zhou X, Lu X, Richard C, Xiong W, Litchfield DW, Bittman R, Arthur G. 1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells. J Clin Invest. 1996 Aug 15;98(4):937-44. PMID:8770865
Erukulla RK, Zhou X, Samadder P, Arthur G, Bittman R. Synthesis and evaluation of the antiproliferative effects of 1-O-hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D- glucopyranosyl)-sn-glycerol and 1-O-hexadecyl-2-O-methyl-3-0- (2'-amino-2'-deoxy-beta-D-glucopyranosyl)-sn-glycerol on epithelial cancer cell growth. J Med Chem. 1996 Mar 29;39(7):1545-8. PMID:8691486
Research Publications: PubMed
There is no current funding at this time.