Professor, Department of Biochemistry and Medical Genetics
Scientist, Children’s Hospital Research Institute of Manitoba
Senior Scientist, Research Institute in Oncology and Hematology
Director, Manitoba Epigenetic Network
Canada Research Chair in Chromatin Dynamics
Fellow, Royal Society of Canada
Fellow, Canadian Academy of Health Sciences
My research interests include epigenetic regulation of gene expression in normal and diseased cells, signal transduction pathways, and biomarkers in the detection of disease. My research program explores the role of chromatin modifiers in regulating gene expression. My early work reported that butyrate was a histone deacetylase inhibitor which arrested cancer cell proliferation. Recent research from my laboratory reported that histone deacetylases act from RNA to catalyze dynamic acetylation of histones bound to transcribed genes. My current research program explores the mechanisms by which histone modifications associated with the transcribed genes body communicate with proteins associate with RNA to regulate pre-mRNA splicing. My laboratory is also interested in working out the mechanisms by which signals (mitogens) received at the cell surface are transmitted into the nucleus via a signal transduction pathway, called the RAS-mitogen activated protein kinase pathway, to turn on specific genes (immediate early genes). My recent endeavours explore the role of DNA methylation in diseases such as fetal alcohol spectrum disorder.