Assistant Professor, Department of Physiology & Pathophysiology
Research Scientist, Children’s Hospital Research Institute of Manitoba, DREAM
My research is focused on understanding the mechanisms that cause insufficient insulin secretion by the pancreatic beta cell during the development of type 2 diabetes (T2D). Recent studies have shown that the gestational environment is an important determinant of the health outcomes of the offspring. For example, mothers with diabetes during pregnancy have a significantly greater chance of their children developing type 2 diabetes later-in-life. While there is certainly a strong genetic component to T2D, epigenetic influences also play an important role. As such, I am interested in understanding the epigenetic changes that, as a result of maternal diabetes, cause beta cell dysfunction and ultimately the development of T2D in the offspring. We hope that by understanding how the environment influences the genetics of the beta cell, we can create novel therapies to prevent or delay T2D onset.
603 John Buhler Research Center