Chemosensation, Clinical Pharmacology and Oral Health

Chemosensation and Clinical Pharmacology: The pulmonary circulation has idiosyncratic responses to many existing vasoactive agents, and many GPCR signal systems understood to act in the oral cavity and airway may also have functions in the pulmonary circuit. Neonatal circulatory transition involves a tightly regulated series of pulmonary vasodilator signals, many of which are disabled in the context of hypoxia or inflammation. We have developed excellent model system to study the developmental pharmacology of pulmonary-active GPCRs in vitro, ex vivo and in vivo.

 

The following areas of research can be explored using MCSB infrastructure and expertise:

  • Taste GPCR distribution, function and developmental pharmacology in the pulmonary circuit.
  • Search for novel ligands for known pulmonary vasodilator GPCRs or activators of downstream   signaling pathways.
  • Explication of pulmonary arterial effects of GPCR-mediated airway or vascular smooth muscle relaxants.

Chemosensation and Oral Health: The areas of research our group is interested in pursuing are:

  • Explore the relationship between taste and prevalence of early childhood caries.
  • Explore the relationship between taste and dental caries in children, adolescents, and adults.
  • Explore the relationship between taste perception and future caries-risk.
  • Improve the palatability of clinical dental products.