Chemosensation and Clinical Pharmacology: The pulmonary circulation has idiosyncratic responses to many existing vasoactive agents, and many GPCR signal systems understood to act in the oral cavity and airway may also have functions in the pulmonary circuit. Neonatal circulatory transition involves a tightly regulated series of pulmonary vasodilator signals, many of which are disabled in the context of hypoxia or inflammation. We have developed excellent model system to study the developmental pharmacology of pulmonary-active GPCRs in vitro, ex vivo and in vivo.
The following areas of research can be explored using MCSB infrastructure and expertise:
Chemosensation and Oral Health: The areas of research our group is interested in pursuing are: