Principal Investigators

Dr. Silvia Cardona | Dr. Prashen Chelikani | Dr. Kangmin Duan | Dr. Shyamala Dakshinamurti | Dr. Anastasia Kelekis-Cholakis | Dr. Robert (Bob) Schroth |
Dr. Ayush Kumar
| Dr. James Elliott Scott | Dr. Rotimi Aluko | Dr. Raj Bhullar |
Dr. John Sorensen
  |


Dr. Silvia Cardona

Silvia Cardova
Associate Professor, Department of Microbiology
Associate Professor, Department of Medical Microbiology

Resistance to antibiotics is on the rise and the antibiotic discovery pipeline is running dry, especially for Gram-negative bacteria. Thus, novel approaches for antibiotic discovery are urgently needed. Our laboratory uses genomics tools to understand the molecular mechanisms controlling bacterial growth with the goal to find novel antibacterial therapies. We use the opportunistic pathogen Burkholderia cenocepacia as the model organism of our research. Our research projects include 1) metabolic inhibition of quorum sensing-related pathogenicity, and 2) chemogenomic approaches to understand the mechanism of action of novel antibacterial molecules.

silvia.cardona@umanitoba.ca
Phone: 204-474-8997
Lab: http://cardonalab.org

Department of Microbiology
45 Chancellors Circle
Buller Building Room 418
University of Manitoba
Winnipeg, MB, R3T 2N2


 Dr. Prashen Chelikani 

Dr. Prashen C

Professor, Department of Oral Biology

Professor, Department of Pharmacology and Therapeutics

Scientist, Children’s Hospital Research Institute of Manitoba

 

Research in my lab is focused on G protein-coupled receptors (GPCRs). GPCRs constitute the largest and most diverse group of membrane proteins. These proteins respond to diverse extracellular stimuli including light, peptides, hormones and tastants. We use a combination of molecular, biochemical and physiological techniques to unravel details of the distribution and mechanisms of action of taste receptors and other GPCRs. Our discovery work is focused on understanding the role of these receptors in normal and pathophysiological conditions, and in pursuing structure-function studies. Our applied work is focused on developing novel taste modifiers and GPCR based immunoassays.


Prashen.Chelikani@umanitoba.ca

Phone: 204-789-3539

Lab: http://home.cc.umanitoba.ca/~chelikan/

D318, 780 Bannatyne Avenue
College of Dentistry, Rady Faculty of Health Sciences
University of Manitoba
Winnipeg, MB R3E 0W2


Dr. Kangmin Duan

Kangmin

Associate Professor and Graduate Chair, Department of Oral Biology

Associate Professor, Department of Medical Microbiology

Scientist, Children’s Hospital Research Institute of Manitoba

 

Infectious disease is the leading cause of human death, accounting for about a quarter of all the deaths worldwide. Antibiotic resistance among bacterial pathogens is increasingly making the once extremely successful drugs ineffective and poses an ominous threat to human health. To encounter such a challenge, it is critical to investigate bacterial pathogenesis and the molecular mechanisms of drug resistance. The research interests in Dr. Duan’s lab include1) regulations and genetic networks of bacterial virulence factors, 2) interactions and signal transduction between microbes and within microbial communities, and 3) new antimicrobial targets and development of new antimicrobial strategies.

 

Kangmin.Duan@umanitoba.ca

Phone: 204-272-3185

D35B, 780 Bannatyne Avenue

College of Dentistry, Rady Faculty of Health Sciences

University of Manitoba

Winnipeg, MB R3E 0W2


 Dr. Shyamala Dakshinamurti

Shyamala

Associate Professor, Department of Pediatrics & Child Health

Associate Professor, Department of Physiology & Pathophysiology

Clinician Scientist, Children’s Hospital Research Institute of Manitoba

 

Dr. Dakshinamurti is a neonatologist and biomedical researcher, Associate Professor of Pediatrics and Physiology at the University of Manitoba, in the Neonatal Pulmonary Biology lab within the Biology of Breathing research group, Children’s Hospital Research Institute of Manitoba. Dr Dakshinamurti is also Research Director and Scholarly Oversight Committee Chair for the University of Manitoba’s Neonatology Fellowship Program. Her areas of research interest are pulmonary hemodynamics during newborn circulatory transition, and the physiology and pharmacology of vascular smooth muscle in the neonatal pulmonary circuit. In specific, the Dakshinamurti lab studies hypoxia and oxidative stress in pulmonary artery smooth muscle, and prostanoid receptor signaling in the disease Persistent Pulmonary Hypertension of the Newborn. The lab will be exploring GPCR-mediated pulmonary arterial vasoconstrictor signaling pathways under the aegis of the Manitoba Chemosensory Biology (MCSB) Research Group.

 

Neonatal Pulmonary Biology Laboratory

Rm 604 Children’s Hospital Research Institute of Manitoba

715 McDermot Avenue, Winnipeg Canada R3E 3P4

Section of Neonatology

WS012 Women's Hospital

735 Notre Dame Ave, Winnipeg Canada R3A 0L8

Phone: 204-787-4218; Fax: 204-787-1587


Dr. Anastasia Kelekis-Cholakis

Anastasia Kelekis-Cholakis

Associate Professor, Department of Dental Diagnostic and Surgical Sciences
Division Head of Periodontology
Program Director of Graduate Periodontics

Dr. Anastasia Kelekis-Cholakis (BA, DMD, Dip Perio, FRCDC ) is an Associate Professor in the Department of Dental Diagnostic and Surgical Sciences  and Program Director of the Graduate Periodontics Program(College of Dentistry) at the University of Manitoba. Dental implants are extensively used in dentistry worldwide but there is incomplete understanding about the nature of peri-implant inflammation and bone loss. Dr. Kelekis-Cholakis’s research interest is in peri-implant bone loss and the use of pro-inflammatory mediators as predictors of peri-implant disease. Dr. Kelekis-Cholakis is looking forward to collaborating with the Manitoba Chemosensory Biology (MCSB) Research Group and investigating the presence of certain peri-implant cytokines as predictors of future peri-implant bone loss.

Anastasia.Cholakis@umanitoba.ca
Phone: 204-975-7765
http://umanitoba.ca/faculties/health_sciences/dentistry/ddss/ddss_cholakis.html


Dr. Robert (Bob) Schroth

 

bob 

Associate Professor, Department of Preventive Dental Science

Associate Professor, Department of Pediatrics & Child Health

Associate Professor, Community Health Sciences

Clinician Scientist, Children’s Hospital Research Institute of Manitoba

Dr. Robert Schroth (DMD MSc PhD) is an Associate Professor in the Department of Preventive Dental Science (College of Dentistry) and the Departments of Pediatrics & Child Health and Community Health Sciences (Max Rady College of Medicine) at the University of Manitoba. He is also a research scientist at the Children’s Hospital Research Institute of Manitoba. Dr. Schroth is a dental clinician-scientist, practicing out of two inner city community-based dental clinics in Winnipeg. His research focuses on early childhood oral health and the epidemiology of Early Childhood Caries (ECC) in at-risk populations particularly among Indigenous children. Some of his work has examined the role of prenatal factors, including vitamin D levels, on the oral health of infants and preschool children. His research has also documented associations between ECC and poor nutritional status. He also co-facilitates an early childhood oral health promotion and ECC prevention project in Manitoba, Healthy Smile Happy Child, which uses community development principles to promote oral health, and includes program evaluation and research.

Dr. Schroth is pleased to join the Manitoba Chemosensory Biology (MCSB) Research Group to undertake studies relating to the association between caries and taste in children and adolescents. This partnership will help to understand the role that taste may have in determining a child’s risk for developing caries, including ECC.

 

umschrot@cc.umanitoba.ca

Phone: 204-975-7764

http://chrim.ca/researcher/robert-schroth/

http://www.wrha.mb.ca/healthinfo/preventill/oral_child.php


 

Dr. Ayush Kumar

Ayush
Associate Professor, Department of Microbiology
Associate Professor, Department of Medical Microbiology

Antibiotic resistance in bacteria is arguably the biggest threat to the human health in the 21st century.  It is severely compromising our ability to cure bacterial infections. The problem of resistance of bacteria to existing antibiotics is further complicated by the dearth of any new antibiotics coming to the market.  Efforts to design new and effective antibiotics need a better understanding of the molecular mechanisms that are responsible for antibiotic resistance in bacteria.  The primary focus of our laboratory is to understand these mechanisms as well as to understand the molecular interplay between antibiotic resistance and virulence.  We are also interested in biocide-antibiotic cross resistance as well in studying the distribution of antibiotic resistance genes in the environments.

Ayush.Kumar@umanitoba.ca
Phone: 204-474-8286
Lab: https://sites.google.com/site/ayushkumarlab/home
Twitter: @ayushkumarlab

Department of Microbiology

418 Buller Building
University of Manitoba
Winnipeg, MB R3T 2N2


  

Dr. James Elliott Scott

James 

Professor and Head, Department of Oral Biology

Professor, Department of Human Anatomy and Cell Sciences

Scientist, Children’s Hospital Research Institute of Manitoba

 

Our lab has for many years been examining the effects of nicotine and/or cotinine on pulmonary surfactant production in fetal rat lung cells as well as the ability of these compounds to alter surfactant function in vitro. In addition we have examined the effects of tobacco smoke extract on insulin-like growth factor role in fetal lung cell function since smoking during pregnancy has been associated with low birth weight in infants at term gestation. The results suggest that tobacco smoke inhalation has numerous deleterious effects on both the synthesis and production of surfactant as well as direct effects on the ability of pulmonary surfactant to function in the lungs of the newborn infant. Dr. Scott serves as Editor-in-Chief for the journal Tobacco Induced Diseases.

 

JamesElliott.Scott@umanitoba.ca 
Phone: 204-789-3535

D033, 780 Bannatyne Avenue

College of Dentistry, Rady Faculty of Health Sciences

University of Manitoba

Winnipeg, MB R3E 0W2


Dr. Rotimi Aluko

 

Rotimi
Professor, Department of Human Nutritional Sciences

Certified Food Scientist (CFS)

 

Dr. Rotimi Aluko is a Professor in the Department of Human Nutritional Sciences at the University of Manitoba, Winnipeg, Canada. In 1996, he obtained a PhD degree in Food Science from the University of Guelph, Ontario, Canada. In addition to his undergraduate and graduate teaching duties at the University of Manitoba, his research program focuses on structure-function properties of food proteins as well as development of natural food protein-derived bioactive peptides, especially for the prevention and/or management of hypertension and oxidative stress. He is a pioneer researcher in the field of plant seed bioactive peptides and value-added utilization of plant seed proteins. He also has an active research program examining the structure-function properties of T2R peptide agonists and antagonists. He has published journal articles that demonstrate potential use of plant seed peptides for the treatment of hypertension and oxidative stress-related symptoms. Dr. Aluko holds two patents on the antihypertensive properties of plant seed peptides and is heavily involved in technology transfer to the food and nutrition industry. He serves as an Associate Editor for Journal of Functional Foods as well as Current Topics in Nutraceutical Research.

 

Rotimi.Aluko@umanitoba.ca

Phone: 204-474-9555

Lab: http://umanitoba.ca/faculties/afs/dept/hns/staff/aluko.html

Citation record: http://scholar.google.ca/citations?user=tm5Q5O4AAAAJ&hl=en

 

W567 Duff Roblin Building

Department of Human Nutritional Sciences

University of Manitoba

Winnipeg, MB R3T 2N2


Dr. Raj Bhullar

raj
Professor, Department of Oral Biology

Professor, Department of Biochemistry and Medical Genetics

Associate Dean (Research), College of Dentistry

 

Regulation of cell function is dependent on the decoding of information and its transduction to the appropriate molecules in the cell. Guanine nucleotide binding proteins (G-proteins) play a central role in these signal transduction pathways of the cell. Our lab is investigating the regulation and the function of various G-proteins in the cell. In particular, we are interested in the regulation and function of a subset of G-proteins termed, small G-proteins. In one project we are investigating the role calmodulin in the function of small G-proteins. In another project, we are investigating the role of bitter compounds and taste receptors in the function of small G-proteins.


Rajinder.Bhullar@umanitoba.ca

Phone: 204-789-3703

 

D328, 780 Bannatyne Avenue

College of Dentistry, Rady Faculty of Health Sciences

University of Manitoba

Winnipeg, MB R3E 0W2


Dr. John Sorensen

 Sorenson

Associate Professor, Department of Chemistry

My research program is interested in novel problems in the area of natural products chemistry with a strong focus on biosynthesis. Our attention will be on small bioactive molecules that possess interesting biological activity. In particular we focus on linking the genes (and gene clusters) in the microorganism with the profile of small organic molecules that are produced by these organisms. We have been focusing on the polyphenolic natural products produced by lichen fungi. One of our ongoing interests is to be able to deduce the signals that are involved in triggering natural product biosynthesis in lichen and other fungi.

John.Sorensen@umanitoba.ca 
Phone: 204-474-9504
Lab webpage: https://home.cc.umanitoba.ca/~sorense0/