Scope of Activities Envisaged

The activities of the group will consist of research and training of postdoctoral fellows, graduate students, DMD candidates, MD candidates and other trainees in chemosensory biology, host a seminar program, make available access to members for in-house modeling suites for studying protein-ligand/drug interactions, and undertake collaboration with other chemosensory biology researchers in Canada and internationally.

 

The research thrust of the group will focus on four broad areas outlined below.

 

1. Taste chemosensation. Includes research on taste receptor biology, taste disorders, food

chemistry and elucidation of novel taste blockers.

 

2. Bacterial chemosensation. Includes research on bacterial biofilms, efflux pumps, quorum sensing, and bacteria-host cell communications with a specific focus on Cystic Fibrosis disease.

 

3. Chemosensory signal transduction. Focus on signal transduction by chemosensory proteins that are druggable targets (GPCRs), small G proteins, and studying protein-drug interactions.

 

4. Chemosensation, Clinical Pharmacology and Oral Health. Research on pharmacogenomics, studies relating to the association between caries and taste in children and adolescents, and palatability of oral formulations.