Dr. Carla Taylor

Position: Professor

Office:
Department of Food and Human Nutritional Sciences
W569 Duff Roblin Building
University of Manitoba
Winnipeg, MB R3T 2N2 Canada

Phone No.: (204) 258-1361

Fax No.: (204) 237-4018

E-mail: carla.taylor@umanitoba.ca

Dr. Taylor investigates the effects of various dietary components on obesity, insulin resistance and vascular health using animal models and human studies. Specific dietary components she is researching include omega-3 fatty acids, conjugated linoleic acid, and plant-based bioactives in crops such as buckwheat and pulses. She is also researching the effects of zinc on antioxidant and immune defense.

Education:

Ph.D. (Department of Nutritional Sciences, University of Guelph), 1990
B.H. Ecol. (Department of Foods and Nutrition, University of Manitoba), 1984

Research Interests:

Dietary modulation of insulin resistance and obesity:  
Effects of dietary fatty acids [omega-3 fatty acids, conjugated linoleic acid (CLA)] and bioactive compounds found in plants/agricultural crops (e.g. buckwheat, pulses) on glycemic control, insulin resistance, adipokines and adipose function.

Nutrition, antioxidant and immune defense:  
Effects of dietary zinc on T-lymphocyte development and zinc-finger proteins involved in cell signaling. 
Protective effects of zinc supplementation during inflammation and heavy metal toxicity.

Recent Publications:

DeClercq, V., Enns, J., Yeganeh, A., Taylor, C.G. & Zahradka, P. (2012) Modulation of cardiovascular function by adipokines. Cardiovasc. Hematol. Disord. Drug. Targets, in press (PMID 22882074)

Mohankumar, S.K., Taylor, C.G., Siemens, L. & Zahradka, P. (2012) Activation of phosphatidyl-3 kinase, AMP-activated kinase and AKt substrate-160 kDa by trans-10, cis-12 conjugated linoleic acid mediates skeletal muscle glucose uptake.  J. Nutr. Biochem., in press (PMID 22704782)

Fuerst, M., Taylor, C.G., Wright, B., Taylor, C.G. & Zahradka, P. (2012) Inhibition of smooth muscle cell proliferation by adiponectin requires proteolytic conversion to its globular form. J. Endocrinol. 215:107-117.

Mohankumar, S.K., Hanke, D., Siemens, L., Cattini, A., Enns, J., Shen, J., Reaney, M., Zahradka, P. & Taylor, C.G. (2012) Dietary supplementation of trans-11-vaccenic acid reduces adipocyte size but neither aggravates nor attenuates obesity-mediated metabolic abnormalities in fa/fa Zucker rats. Br. J. Nutr. 23:1-9.

Northcott, J.M., Yeganeh, A., Taylor, C.G., Zahradka, P. & Wigle, J.T. (2012) Adipokines and the cardiovascular system: mechanisms mediating health and disease. Can. J. Physiol. Pharmacol. 90:1029-1059.

Louis, X.L., Thandapilly, S.J., Mohankumar, S.K., Yu, L., Taylor, C.G., Zahradka, P. & Netticadan T. (2012) Treatment with low dose resveratrol reverses cardiac impairment in obese prone but not in obese resistant rats. J. Nutr. Biochem. 23:1163-1169.

Blewett, H.J. & Taylor, C.G. (2012) Dietary zinc deficiency in rodents: Effects on T-cell development, maturation and phenotypes. Nutrients 4:449-466.  

DeClercq, V., Taylor, C.G. & Zahradka, P. (2012) Isomer-specific effects of conjugated linoleic acid (CLA) on blood pressure, adipocyte size and function. Br. J. Nutr. 107:1413-1421.

Baranowski, M., Enns, J., Blewett, H., Yakandawalu, U., Zahradka, P. & Taylor, C.G. (2012) Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats. Cytokine 59:382-391.

Berry, R., Hydamaka, A., Noto, A., Kotyk, E., Zahradka, P. & Taylor, C.G. (2012) Grazing period variations in cows milk vaccenic acid (VA) and conjugated linoleic acid (CLA). J. Nutr. Food Sci. 2:1-7.

Mohankumar, S.K., Taylor, C.G., Siemens, L. & Zahradka, P. (2012) Acute exposure of L6 myotubes to cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers stimulates glucose uptake by modulating Ca2+/calmodulin-dependent protein kinase II. Int. J. Biochem. Cell Biol. 44:1321-1330.

Mohankumar, S.K., Taylor, C.G. and Zahradka, P. (2012) Domain-dependent modulation of insulin-induced AS160 phosphorylation and glucose uptake by Ca2+/calmodulin-dependent protein kinase II in L6 myotubes.  Cell. Signal. 24:302-308.

DeClercq, V., Taylor, C.G., Wigle, J., Wright, B., Tworek, L., and Zahradka, P.  (2011) Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity. J. Nutr. Biochem.  23:487-493.

Suh, M., Merrells, K.J., Dick, A., and Taylor, C.G. (2011) Testes of obese rats are highly responsive to n-3 long chain fatty acids. Br. J. Nutr.  13:1-8.

Enns, J.E., Taylor, C.G., and Zahradka, P. (2011) Variations in adipokine genes AdipoQ, Lep, and LepR are associated with risk for obesity-related metabolic disease: the modulatory role of gene-nutrient interactions. J. Obesity 2011:168659 (doi:10.1155/2011/168659). 

Thandapilly, S.J., Louis, X.L., Yang, T., Stringer, D.M., Yu, L., Zhang, S., Wigle, J., Kardami, E., Zahradka, P., Taylor, C.G., Anderson, H.D., and Netticadan, T. (2011) Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway. Eur. J. Pharmacol. 668:217-24. 

Prescod, A.L., Halliday, W.C., and Taylor, C.G. (2011) Protein deficiency, but not zinc deficiency, reduces recovery of type 1 and type 2 muscle fibre diameters in the gastrocnemius muscle of growing rats. Br. J. Nutr. 106:675-82.

Zhao, J., Gillam, M.E., Taylor, C.G., and Weiler, H.A. (2010) Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in alpha-linolenic acid but devoid of DHA. J. Nutr. Biochem. 22(9):835-42.

Stringer, D.M., Zahradka, P., DeClercq, V., Ryz, N.R., Diakiw, R., Burr, L.L., Xie, X., and Taylor, C.G. (2010) Modulation of lipid droplet size and lipid droplet proteins by trans-10, cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1801:1375-85.

DeClercq, V.C., Taylor, C.G., and Zahradka, P. (2010) Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa/fa Zucker rats. Lipids 45:1025-33.

Taylor, C.G., Noto, A.D., Stringer, D.M., Froese, S., and Malcolmson, L. (2010) Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes.  J. Am. Coll. Nutr. 29:72-80.

Wojciechowski, P., Juric, D., Louis, X.L., Thandapilly, S.J., Yu, L., Taylor, C.G., and Netticadan, T. (2010) Resveratrol arrests and regresses the development of pressure overload - but not volume overload-induced cardiac hypertrophy in rats. J. Nutr. 140:962-968.

Curran, J., Stringer, D., Wright, B., Taylor, C.G., Przybylski, R., and Zahradka, P. (2010) Biological response of hepatomas to an extract of Fagopyrum esculentum M. (buckwheat) is not mediated by inositols or rutin. J. Agr. Food Chem. 58:3197-3204.  

Massip, L., Garand, C., Paquet, E.R., Cogger, V.C., O'Reilly, J.N., Tworek, L., Hatherell, A., Taylor, C.G., Thorin, E., Zahradka, P., Le Couteur, D.G., and Lebel, M.  2010.  Vitamin C restores healthy aging in a mouse model for Werner syndrome.  FASEB J. 24:158-72.

Gillam, M., Noto, A., Zahradka, P., and Taylor, C.G.  2009.  Improved n-3 fatty acid status does not modulate insulin resistance in fa/fa Zucker rats.  Prostaglandins Leukot Essent Fatty Acids. 81:331-9.

Merrells, K.J., Blewett, H., Jamieson, J.A., Taylor, C.G., and Suh, M.  2009  Relationship between abnormal sperm morphology induced by dietary zinc deficiency and lipid composition in testis of growing rats.  Br. J. Nutr.  102: 226-32.

Ryz, N.R., Weiler, H.A., and Taylor, C.G.  2009  Zinc deficiency reduces bone mineral density in the spine of young adult rats:  A pilot study.  Annal. Nutr. Metab.  54: 218-226.

Szczurek, E.I., Bjornsson, C.S., Noto, A.D. and Taylor, C.G.  2009  Renal metallothionein responds rapidly and site-specifically to zinc repletion in growing rats.  J. Trace Elem. Med. 23: 176-182.

Al-Gindan, Y., Shawarby, M., Noto, A., and Taylor, C.G.  2009 Intestinal inflammation in rats induces metallothionein in colonic submucosa.  J. Clin. Biochem. Nutr. 44: 131-141.

Stringer, D.M., Sellers, E.A.C., Burr, L.L., and Taylor, C.G.  2009  Altered plasma adipokines and markers of oxidative stress suggest increased risk of cardiovascular disease in First Nation youth with obesity or type 2 diabetes mellitus.  Pediatric Diabetes 10: 269-77.

Ryz, N., Meddings, J.B., and Taylor, C.G.  2009  Long-chain inulin increases dendritic cells in the Peyer’s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status.  Br. J. Nutr. 101: 1653-63.

Drury, B., Warford-Woolgar, L.J., Herchak, D.J., Bankovic-Calic, N., Crow, G., Taylor, C.G., Zahradka, P., Ogborn, M.R., and Aukema, H.M.  2009  Dietary trans10, cis12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa Zucker rats.  J. Nutr. 139: 285-290.