Dr. James D. House, Department Head

Position: Professor and Head of Department

Office:
University of Manitoba
Department of Food and Human Nutritional Sciences
Room 208A Human Ecology Building
Winnipeg, MB R3T 2N2 Canada
Phone No.: (204) 474-6837
Fax No.: (204) 474-7593
E-mail: james.house@umanitoba.ca

Education:
Ph.D.              University of Guelph (1996)
B.Sc. (Agr)     University of Guelph (1990)

Research Affiliations
•    Richardson Centre for Functional Foods and Nutraceuticals
•    Canadian Centre for Agri-Food Research in Health and Medicine
•    Department of Animal Science, University of Manitoba


Dr. House conducts research in 3 primary areas:

1)    Protein Quality:  Within this research program, we study the factors (environment, genetics, processing) that impact the amino acid content and digestibility of protein in whole foods & food and feed ingredients.  We have the expertise to measure the amino acid content of samples, Protein Efficiency Ratio (PER), Protein Digestibility-Corrected Amino Acid Score (PDCAAS) and in vitro protein digestibility, using both static and dynamic  (TIM-1) systems.  Our laboratory offers technical services to those requiring protein quality evaluations on foods or food ingredients in support of protein content claim substantiation.  Recent examples of publications include:

a.    House, J.D., Hill, K., Neufeld, J., Franczyk, A., and Nosworthy, M.G.  2019. Determination of the Protein Quality of Almonds (Prunis dulcis L) as Assessed by In Vitro and In Vivo Methodologies.  Food Sci. Nutr. (In Press).
b.    Wiggins, A.K.A, Anderson, H.G., and House, J.D.  2019.  Commentary:  Research Gaps for the Substantiation of Protein Content Claims on Foods.  Appl. Physiol. Nutr. Metab. 44: 95-98

2)    Nutritional Regulation of Sulphur Amino Acid Metabolism:  Within this research program we are studying the factors that regulate the metabolism of the sulphur amino acids methionine and cysteine, and their metabolites, within animals (rodents, chickens, humans).  Recent research has focused on the interplay between water-soluble vitamin nutrition and the metabolism of the amino acid homocysteine, a central metabolite in sulphur amino acid metabolism.  Recent examples of publications include:

a.    Mayengbam, S., Raposo, S., Aliani, M., and House, J.D. 2016.  A Vitamin B-6 antagonist from flaxseed perturbs amino acid metabolism in moderately vitamin B-6 deficient male rats.  J. Nutr. 146: 14-20
b.    Mayengbam, S., House, J.D. and Aliani, M.  2016.  A non-targeted metabolomics approach to identify potential plasma lipophilic biomarkers of inadequate vitamin B6 status, induced by low B6 intake, exposure to the anti-B6 factors 1-amino-D-proline, or their interaction, in a rat model.  Eur. J. Nutr. 55: 1213-1223. 

3)    Sustainable Egg Production:  Our laboratory has a long-standing commitment to sustainable egg production, by conducting research to:  a) evaluate alternative housing systems for laying hens; b) optimize phosphorus feeding strategies to reduce phosphorus excretion and the potential for subsequent environmental impacts; and 3) developing new market options for egg producers (omega-3 enriched and folate-enriched eggs; novel egg-derived ingredients) to ensure economic sustainability of the sector.  Recent examples of publications include:

a.    Jing, M., Zhao, S., Rogiewicz, A., Slominski, B., and House, J.D. 2018.  Assessment of the minimal available phosphorus needs of laying hens: Implications for phosphorus management strategies. Poult. Sci. 97: 2400-2410.
b.    Naderi, N., Doyen, A., House, J.D., and Pouliot, Y.  2017.  The use of high hydrostatic pressure to generate folate-enriched extracts from the granule fraction of hen's egg yolk. Food Chem. 232: 253-262.


You can see all of my papers at ORCID:  https://orcid.org/0000-0003-1389-5491

Selected Publications:

2019

Wiggins, A.K.A, Anderson, H.G., and House, J.D.  2019.  Commentary:  Research Gaps for the Substantiation of Protein Content Claims on Foods.  Appl. Physiol. Nutr. Metab. 44: 95-98

Wang, S., Nosworthy, M.G., House, J.D., Ai, Y., Hood-Niefer, S., and Nickerson, M.T.  2019.  Effect of barrel temperature and feed moisture on the physical properties of chickpea–sorghum and chickpea–maize extrudates, and the functionality and nutritional value of their resultant flours—Part II.  Cereal Chem.  96:  621-633.

Akkad, R., Kharraz, E., Han, J., House, J.D., and Curtis, J.M. 2019.  Characterisation of the volatile flavour compounds in low and high tannin faba beans (Vicia faba var. minor) grown in Alberta, Canada. Food Res Int. 120: 285-294.

House, J.D., Hill, K., Neufeld, J., Franczyk, A., and Nosworthy, M.G.  2019. Determination of the Protein Quality of Almonds (Prunis dulcis L) as Assessed by In Vitro and In Vivo Methodologies.  Food Sci. Nutr. (In Press).

Guldiken, B., Yovchev, A., Nosworthy, M.G., Stone, A.K., House, J.D., Hood-Niefer, S., and Nickerson, M.T. 2019.  Effect of extrusion conditions on the physical properties of desi chickpea-barley extrudates and quality attributes of their resulting flours. J. Texture Stud. 2019 Jul 19. doi: 10.1111/jtxs.12470.

2018

Nosworthy, M.G., Medina, G., Franczyk, A.J., Neufeld., J., Appah, P., Utioh, A., Frohlich, P, and House, J.D. 2018. Effect of processing on the in vitro and in vivo protein quality of red and green lentils (Lens culinaris). 240: 588-593.

Jing, M., Zhao, S., Rogiewicz, A., Slominski, B., and House, J.D. 2018.  Assessment of the Minimal Available Phosphorus Needs of Pullets throughout Development.  Poult. Sci. 97: 557-567.

Jing, M., Zhao, S., Rogiewicz, A., Slominski, B., and House, J.D. 2018.  Assessment of the minimal available phosphorus needs of laying hens: Implications for phosphorus management strategies. Poult. Sci. 97: 2400-2410.

She, Y., MacKay, D.S., House, J.D., and Jones, P.J.H.  2018.  CYP7A1-rs3808607: A single nucleotide polymorphism associated with cholesterol response to functional foods.  Curr. Opin. Food Sci. 20: 19-23.

Bai, T., Nosworthy, M.G., House, J.D, and Nickerson, M.T.  2018. Effect of tempering moisture and infrared heating temperature on the nutritional properties of Desi chickpea and hull-less barley flours, and their blends.  Food Res. Int.  108: 430-439.

Cabak, B., Nosworthy, M.G., Stone, A., Korber, D., Tanaka, T., House, J.D., and Nickerson, M.T.  2018.  Effect of fermentation on the protein digestibility and levels of non-nutritive compounds of pea protein concentrate.  Food Tech. Biotech. 56: 257-264.

Nosworthy, M.G., Medina, G., Franczyk, A.J., Neufeld., J., Appah, P., Utioh, A., Frohlich, P, and House, J.D. 2018.  Effect of processing on the in vitro and in vivo protein quality of beans (Phaseolus vulgaris and Vicia Faba).  Nutrients.  10(6). pii: E671. doi: 10.3390/nu10060671

Sid V, Shang Y, Siow YL, Hewage SM, House JD, O K. (2018) Folic acid supplementation attenuates chronic hepatic inflammation in high-fat diet fed mice. Lipids. 53:709-716

Tamanna, N., Mayengbam, S., House, J.D., and Treberg, J.R.  2018.  Methionine restriction leads to hyperhomocysteinemia and alters hepatic H2S production capacity in Fischer-344 rats.  Mech. Ageing Dev. 176:  9-18.

2017


Neijat, M., Eck, P., and House, J.D.  2017.  Synthesized versus preformed omega-3 fatty acids in chicken egg, liver and adipose tissue and the expression of genes associated with hepatic lipid metabolism. Prostaglandins Leukot. Essent. Fatty Acids 119: 1-17

Naderi, N., Doyen, A., House, J.D., and Pouliot, Y.  2017.  The use of high hydrostatic pressure to generate folate-enriched extracts from the granule fraction of hen's egg yolk. Food Chem. 232: 253-262.

Nosworthy, M. and House, J.D.  2017.  Recent advances in the determination of the quality of dietary proteins:  Implications for pulses.  Cereal Chem.  94: 49-57.

Jing, M., Zhao, S., and House, J.D.  2017.  Performance and tissue fatty acid profile of broiler chickens and laying hens fed hemp oil and HempOmega™.  Poult. Sci. 96:1809-1819.

Nosworthy, M.G., Zimoch-Korzycka, A., Franczyk, A., Neufeld, J., and House, J.D. 2017.  Impact of processing on the protein quality of pinto bean (Phaseolus vulgaris) & buckwheat (Fagopyrum esculentum Moench ) flours and blends, as determined by in vitro and in vivo methodologies. J. Agric. Food Chem. 65:3919-3925.

Nosworthy, M.G., Neufeld, J., Reed, L., Frohlich, P., Boux, G., Malcolmson, L. and House, J.D.  2017.   Determination of the protein quality of cooked Canadian pulses. Food Sci. Nutr. 5: 896-903.

Marinangeli, C.P.F., and House, J.D.  2017.  Potential impact of the digestible indispensable amino acid score as a measure of protein quality on dietary regulations and health.  Nutr. Reviews 75: 658-667.

Naderi, N., House, J.D., Pouliot, Y., and Doyen, A.  2017.  Review: Effects of high hydrostatic pressure processing on hen egg compounds and egg products. Comp. Rev. Food Sci. Food Safety 16: 707-720.

Nosworthy, M.G., Tulbek, M., and House, J.D.  2017.  Does the concentration, isolation or deflavouring of pea, lentil and faba bean protein alter protein quality?  Cereal Foods World 62: 139-142.

Naderi, N, Doyen, A., Pouliot, Y., and House, J.D.  2017.  High hydrostatic pressure effect in extraction of 5-methyltetrahydrofolate (5-MTHF) from egg yolk and granule fractions. Innov. Food Sci. Emerg. Technol. 43: 191-200.

Nosworthy, M.G., Medina, G., Franczyk, A.J., Neufeld., J., Appah, P., Utioh, A., Frohlich, P, and House, J.D. 2017.  Effect of processing on the in vitro and in vivo protein quality of yellow and green split peas (Pisum sativum). J. Agric. Food Chem.  65:  7790-7796.

Naderi, N, Pouliot, Y., House, J.D. and Doyen, A. 2017.  Effect of freezing, thermal pasteurization, and hydrostatic pressure on fractionation and folate recovery in egg yolk.  J. Agric. Food Chem. 65: 7774-7780.

2016

Mayengbam, S., Raposo, S., Aliani, M., and House, J.D. 2016.  A Vitamin B-6 antagonist from flaxseed perturbs amino acid metabolism in moderately vitamin B-6 deficient male rats.  J. Nutr. 146: 14-20.

Mayengbam, S., House, J.D. and Aliani, M.  2016.  A non-targeted metabolomics approach to identify potential plasma lipophilic biomarkers of inadequate vitamin B6 status, induced by low B6 intake, exposure to the anti-B6 factors 1-amino-D-proline, or their interaction, in a rat model.  Eur. J. Nutr. 55: 1213-1223.

Carragher, J.F., Muhlhausler, B.S., Geier, M.S., House, J.D., Hughes, R.J., and Gibson, R.A. 2016.  Effect of dietary ALA on growth rate, feed conversion ratio, mortality rate and breast meat omega-3 LCPUFA content in broiler chickens.  Anim. Prod. Sci. 56: 815-823.

Naderi, N., Doyen, A., House, J.D., and Pouliot, Y.  2016.  Effect of selected pretreatments to increase the folate content of granule suspensions prepared from hen egg yolk.  Food Sci. Tech. 68: 341-348.

Neijat, M., Suh, M., Neufeld, J., and House, J.D.  2016.  Hempseed products fed to hens effectively increased n-3 polyunsaturated fatty acids in total, triacylglycerol and phospholipid of egg yolk.  Lipids.  51: 601-614.

Neijat, M., Suh, M., Neufeld, J., and House, J.D.  2016.  In depth fatty acid profile analysis of total and individual lipid classes in egg yolk, liver and plasma as a function of increasing levels of alpha-linolenic acid derived from hempseed products in laying hen diets. Lipids.  51: 615-633.

Sarna, L.K., Sid, V., Wang, P., Siow, Y.L., House, J.D. and O, K.  2016.  Tyrosol reduces high fat diet induced hepatic oxidative stress through activation of cystathionine-B-synthase and cystathionine-gamma-lyase.  Lipids. 51: 583-590.

Goldberg, E., Ryland, D., Aliani, M., and House, J.D.  2016.  Interactions between canola meal and flaxseed oil in the diets of white Lohmann hens on fatty acid profile and sensory characteristics of table eggs.  Poult. Sci.  95: 1805-1812.
Neijat, M., Ojekudo, O., and House, J.D. 2016.  Effect of flaxseed oil and microalgae DHA on the production performance, fatty acids and total lipids of egg yolk and plasma in laying hens. Prostaglandins Leukot Essent Fatty Acids. 115: 77-88.

2015

Jing, M., Rech, L, Wu, Y., Goltz, D., Taylor, C.G., and House, J.D.  2015.  Effects of zinc deficiency and zinc supplementation on homocysteine levels and related enzyme expression in rats.  J. Trace Elem. Med. Biol.  30:  77-82.

Mayengbam, S., Raposo, S., Aliani, M., and House, J.D.  2015.  The anti-pyridoxine factor 1-amino D-proline, derived from flaxseed, perturbs homocysteine metabolism in moderately vitamin B6 deficient rats.  J. Nutr. Biochem. 26: 241-249.

Devassy, J., Caligiuri, S., Mayengbam, S., Ibrahim, N., Zahradka, P., Taylor, C., House, J.D., and Aukema, H.M. 2015.  Dietary restriction in moderately obese rats provides more benefits and fewer potential risks than a high protein diet.  App. Physiol. Nutr. Met.  40: 334-342.

Sid, V., Wu, N., Sarna, L.K., Siow, Y.L., House, J.D., and O, K. 2015.  Folic acid supplementation during high fat diet feeding restores AMP-activated protein kinase (AMPK) activation via an AMP-LKB1 dependent mechanism.   Am. J. Physiol. Reg. Int. Comp. Physiol.  309:R1215-R1225.