Dr. Harold Aukema

Position: Professor

Office:

University of Manitoba
Department of Human Nutritional Sciences
W573 Duff Roblin Building
University of Manitoba
Winnipeg, MB R3T 2N2 Canada

Phone No.:
(204) 474-8076

Fax No.:
(204) 474-7593

E-mail:
harold.aukema@umanitoba.ca


Dr. Aukema is examining the effects of dietary components on kidney health and on signaling molecules in normal and diseased kidneys due to inherited disease, diabetes, and obesity. This research also provides evidence for the physiologic and metabolic basis of dietary recommendations for dietary protein and for omega-3 fatty acids.

Education:


B.Sc. University of Guelph
M.Sc. University of Guelph
Ph.D. University of Guelph

RESEARCH INTERESTS

Dietary Recommendations

Physiologic and metabolic basis of dietary recommendations for dietary protein and for omega-3 fatty acids

Nutrition and the Kidney

Kidney Health and Disease:  Effects of diet, nutraceuticals and functional foods
Renal Eicosanoids:  Dietary effects on eicosanoids in normal kidneys and diseased kidneys resulting from genetic mutations, diabetes and obesity
Fetal Programming:  Effects of perinatal nutrition on kidneys in models of congenital kidney disease

Selected Publications:

Li H, Prairie N, Udenigwe CC, Adebiyi AP, Tappia PS, Aukema HM, et al. Blood pressure lowering effect of a pea protein hydrolysate in hypertensive rats and humans. J Agric Food Chem. 2011;59(18):9854-60.

Wakefield AP, Ogborn MR, Ibrahim N, Aukema HM. A dietary conjugated linoleic acid treatment that slows renal disease progression alters renal cyclooxygenase-2-derived prostanoids in the han: SPRD-cy rat. J Nutr Biochem. 2011.

Wakefield AP, House JD, Ogborn MR, Weiler HA, Aukema HM. A diet with 35% of energy from protein leads to kidney damage in female sprague-dawley rats. Br J Nutr. 2011;106(5):656-63.

Aukema HM, Gauthier J, Roy M, Jia Y, Li H, Aluko RE. Distinctive effects of plant protein sources on renal disease progression and associated cardiac hypertrophy in experimental kidney disease. Molecular Nutrition and Food Research. 2011;55(7):1044-51.

Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, et al. PPAR-γ agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. American Journal of Physiology - Renal Physiology. 2011;300(2):F465-74.

Joseph SV, Liu X, Wakefield A, Chouinard PY, Aukema H, Jones PJH, et al. Trans-8, cis-10+cis-9, trans-11-conjugated linoleic acid mixture alters body composition in syrian golden hamsters fed a hypercholesterolaemic diet. Br J Nutr. 2010;104(10):1443-9.

Ogborn MR, Nitschmann E, Bankovic-Calic N, Weiler HA, Aukema HM. Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet. Exp Biol Med. 2010;235(11):1315-20.

Jia Y, Hwang SY, House JD, Ogborn MR, Weiler HA, O K, et al. Long-term high intake of whole proteins results in renal damage in pigs. J Nutr. 2010;140(9):1646-52.

Pye KM, Wakefield AP, Aukema HM, House JD, Ogborn MR, Weiler HA. A high mixed protein diet reduces body fat without altering the mechanical properties of bone in female rats. J Nutr. 2009;139(11):2099-105.

Fan Y-, Zhan Y, Aukema HM, Davidson LA, Zhou L, Callaway E, et al. Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. J Nutr. 2009;139(7):1328-32.

Peng CY-, Sankaran D, Ogborn MR, Aukema HM. Dietary soy protein selectively reduces renal prostanoids and cyclooxygenases in polycystic kidney disease. Exp Biol Med. 2009;234(7):737-43.

Drury B, Warford-Woolgar LJ, Herchak DJ, Bankovic-Calic N, Crow G, Taylor CG, et al. Dietary trans-10, cis-12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa zucker rats. J Nutr. 2009;139(2):285-90.

Scatliff CE, Bankovic-Calic N, Ogborn MR, Aukema HM. Effects of dietary conjugated linoleic acid in advanced experimental polycystic kidney disease. Nephron - Experimental Nephrology. 2008;110(2):e44-8.

Ogborn MR, Nitschmann E, Goldberg A, Bankovic-Calic N, Weiler HA, Aukema HM. Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney disease. Lipids. 2008;43(9):783-91.

Hwang S-, Taylor CG, Zahradka P, Bankovic-Calic N, Ogborn MR, Aukema HM. Dietary soy protein reduces early renal disease progression and alters prostanoid production in obese fa/fa zucker rats. J Nutr Biochem. 2008;19(4):255-62.

Sankaran D, Lu J, Ogborn MR, Aukema HM. COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition. J Nutr Biochem. 2007;18(12):806-12.

Sankaran D, Bankovic-Calic N, Ogborn MR, Crow G, Aukema HM. Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in han:SPRD-cy rats with inherited kidney disease. American Journal of Physiology - Renal Physiology. 2007;293(3):F821-30.

Sankaran D, Bankovic-Calic N, Cahill L, Yu-Chen Peng C, Ogborn MR, Aukema HM. Late dietary intervention limits benefits of soy protein or flax oil in experimental polycystic kidney disease. Nephron - Experimental Nephrology. 2007;106(4):e122-8.

Weiler HA, Kovacs H, Nitschmann E, Bankovic-Calic N, Aukema H, Ogborn M. Feeding flaxseed oil but not secoisolariciresinol diglucoside results in higher bone mass in healthy rats and rats with kidney disease. Prostaglandins Leukotrienes Essential Fatty Acids. 2007;76(5):269-75.

Cahill LE, Peng CY-, Bankovic-Calic N, Sankaran D, Ogborn MR, Aukema HM. Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring. Br J Nutr. 2007;97(1):77-84.

Ogborn MR, Nitschmann E, Bankovic-Calic N, Weiler HA, Aukema HM. Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender. Lipids 41:1141-1149, 2006.

Sankaran D, Bankovic-Calic N, Peng CYC, Ogborn MR, Aukema HM. Dietary flax oil during pregnancy and lactation retards disease progression in rat offspring with inherited kidney disease. Ped Res 60:729-33, 2006

Warford-Woolgar LJM, Peng C, Shuhyta J, Wakefield AP, Sankaran D, Ogborn MR, Aukema HM. Selectivity of cyclooxygenase (COX) isoform activity and prostanoid production in normal and diseased Han:SPRD-cy rat kidneys. Am J Physiol Renal Physiol 290:F897-904, 2006